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All Studies   Meta Analysis    Recent:   

Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea

Choi et al., Journal of Clinical Medicine, doi:10.3390/jcm9061959
Jun 2020  
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Progression -120% Improvement Relative Risk Metformin for COVID-19  Choi et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? PSM retrospective 72 patients in South Korea (Mar - Mar 2020) Higher progression with metformin (not stat. sig., p=0.26) c19early.org Choi et al., J. Clinical Medicine, Jun 2020 Favorsmetformin Favorscontrol 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
 
*, now with p < 0.00000000001 from 96 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 95 treatments. c19early.org
Retrospective 293 patients in South Korea, showing higher risk of progression with metformin use, without statistical significance.
Study covers metformin and ibuprofen.
risk of progression, 120.0% higher, OR 2.20, p = 0.26, treatment 6 of 36 (16.7%) cases, 3 of 36 (8.3%) controls, case control OR, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Choi et al., 23 Jun 2020, retrospective, South Korea, peer-reviewed, median age 29.0, 8 authors, study period 5 March, 2020 - 18 March, 2020. Contact: kscpjsh@yuhs.ac (corresponding author), tcmhwd@yuhs.ac, overhyun@gmail.com, cpcforever@nate.com, rla20404@naver.com, zun54@naver.com, yessul88@naver.com, jinote0504@gmail.com.
This PaperMetforminAll
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea
Min Hyuk Choi, Hyunmin Ahn, Han Seok Ryu, Byung-Jun Kim, Joonyong Jang, Moonki Jung, Jinuoung Kim, Seok Hoon Jeong
Journal of Clinical Medicine, doi:10.3390/jcm9061959
A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to triage patients. The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. After adjusting for confounding variables, prior history of drug use, including ARB, ibuprofen, and DPP4i was not a risk factor associated with disease progression. Patients treated with lopinavir/ritonavir had significantly shorter progression-free survival than those not receiving lopinavir/ritonavir. KCDC classification I clearly distinguished the improvement/stabilization group from the progression group of COVID-19 patients (AUC 0.817; 95% CI, 0.740-0.895).
Author Contributions: Conceptualization, M.H.C., H.A., and S.H.J.; data curation, M.H.C. and H.A.; writingoriginal draft, M.H.C.; writing-review and editing, H.S.R., B.-J.K., J.J., M.J., and J.K. All authors have read and agreed to the published version of the manuscript. Conflicts of Interest: The authors declare no conflicts of interest. Appendix A
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