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Budesonide for COVID-19: real-time meta analysis of 12 studies

Covid Analysis (Preprint) (meta analysis)
Covid Analysis, Budesonide for COVID-19: real-time meta analysis of 12 studies, (Preprint) (meta analysis)
Jun 2023   Source   PDF  
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• Statistically significant improvements are seen for mortality, progression, and recovery. 8 studies from 8 independent teams in 7 different countries show statistically significant improvements in isolation (4 for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 30% [16‑42%] improvement. Results are similar for Randomized Controlled Trials, similar after exclusions, and similar for peer-reviewed studies. Early treatment is more effective than late treatment.
• Results are robust — in exclusion sensitivity analysis 8 of 12 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
• No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. None of the budesonide studies show zero events with treatment.
• All data to reproduce this paper and sources are in the appendix.
Percentage improvement with budesonide (more)
Early treatmentAll studiesProphylaxisStudies Patients Authors
All studies49% [-617‑96%]30% [16‑42%]***28% [12‑41%]** 1227,682 191
Randomized Controlled TrialsRCTs49% [-617‑96%]33% [-38‑67%]- 53,332 115
Mortality-200% [-7253‑88%]27% [13‑39%]***32% [0‑54%]* 1020,517 162
HospitalizationHosp.12% [-140‑68%]44% [-52‑80%]- 21,578 41
Covid Analysis et al., Jun 2023, preprint, 1 author.
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Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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