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Antiandrogens reduce COVID-19 risk: real-time meta analysis of 49 studies

Covid Analysis, May 2025
https://c19early.org/caaameta.html
7th treatment shown to reduce risk in September 2020, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments.
5,700+ studies for 135 treatments. c19early.org
Significantly lower risk is seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. 29 studies from 23 independent teams in 12 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 30% [21‑38%] lower risk. Results are similar for higher quality and peer-reviewed studies and better for Randomized Controlled Trials.
Results are robust — in exclusion sensitivity analysis 23 of 49 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
This analysis combines the results of several different antiandrogens. Results for individual treatments may vary.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Other treatments are more effective. All data and sources to reproduce this analysis are in the appendix.
Other meta analyses show significant improvements with antiandrogens for mortality1,2, hospitalization2, recovery2, and progression1.
2 meta analyses show significant improvements with antiandrogens for mortality1,2, hospitalization2, recovery2, and progression1.
Covid Analysis et al., May 2025, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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