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Oral booster probiotic bifidobacteria in SARS-COV-2 patients

Bozkurt et al., International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211059677
Nov 2021  
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Probiotics for COVID-19
17th treatment shown to reduce risk in March 2021
*, now known with p = 0.0000013 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Small retrospective 44 hospitalized patients in Turkey, showing improved outcomes with probiotic bifidobacterium, however minimal group details are provided (for example, the age of the control patients is unknown), and no adjustments were made.
The immune effects of probiotics are strain-specific.
This study is excluded in meta analysis: unadjusted results with key group information missing.
Bozkurt et al., 25 Nov 2021, retrospective, Turkey, peer-reviewed, 2 authors.
This PaperProbioticsAll
Oral booster probiotic bifidobacteria in SARS-COV-2 patients
Hüseyin S Bozkurt, Ömer Bilen
International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211059677
Oral booster-single strain probiotic bifidobacteria could be a potential strategy for SARS-CoV-2. This study aims to evaluate the role of oral probiotic Bifidobacterium on moderate/severe SARS-CoV-2 inpatients. In this single-center study, we analyzed data of 44 moderate/severe inpatients with diagnosed COVID-19 in Istanbul Maltepe University Medical Faculty Hospital, 2020 from 1 November 2020 to 15 December 2020. Clinical and medication features were compared and analyzed between patients with or without probiotic. In result, 19 of the 44 patients (43.18%) who were administrated with oral booster-single strain probiotic were discharged with the median inpatient day of 7.6 days which were significantly shorter than those of patients without probiotic. There were significant differences in inpatient days, radiological improvement at day 6 and week 3, and reduction in interleukin-6 levels in those receiving oral probiotic therapy. Although the mortality rate was 5% in the probiotic group, it was 25% in the non-probiotic group. Booster-single strain probiotic bifidobacteria could be an effective treatment strategy for moderate/severe SARS-CoV-2 inpatients to reduce the mortality and length of stay in hospital.
Conclusion Oral booster dose Bifidobacterium animalis subsp. Lactis administration could provide lower mortality, shortening the length of stay in hospital, early radiologic improvement and decrease plasma IL-6 level in moderate/severe SARS-CoV-2 patients. It is still necessary to develop diagnostic strategies to determine the patients to whom this method would be the most applicable. Declaration of Conflicting Interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. ORCID iDs Hüseyin S Bozkurt  Ömer Bilen 
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