Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All probiotics studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchProbioticsProbiotics (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Oral booster probiotic bifidobacteria in SARS-COV-2 patients

Bozkurt et al., International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211059677
Nov 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Probiotics for COVID-19
18th treatment shown to reduce risk in March 2021, now with p = 0.0000011 from 28 studies.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 109 treatments. c19early.org
Small retrospective 44 hospitalized patients in Turkey, showing improved outcomes with probiotic bifidobacterium, however minimal group details are provided (for example, the age of the control patients is unknown), and no adjustments were made.
Probiotic efficacy depends on the specific strains used. Specific microbes may decrease or increase COVID-19 risk1.
This study is excluded in meta analysis: unadjusted results with key group information missing.
Bozkurt et al., 25 Nov 2021, retrospective, Turkey, peer-reviewed, 2 authors.
This PaperProbioticsAll
Oral booster probiotic bifidobacteria in SARS-COV-2 patients
Hüseyin S Bozkurt, Ömer Bilen
International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211059677
Oral booster-single strain probiotic bifidobacteria could be a potential strategy for SARS-CoV-2. This study aims to evaluate the role of oral probiotic Bifidobacterium on moderate/severe SARS-CoV-2 inpatients. In this single-center study, we analyzed data of 44 moderate/severe inpatients with diagnosed COVID-19 in Istanbul Maltepe University Medical Faculty Hospital, 2020 from 1 November 2020 to 15 December 2020. Clinical and medication features were compared and analyzed between patients with or without probiotic. In result, 19 of the 44 patients (43.18%) who were administrated with oral booster-single strain probiotic were discharged with the median inpatient day of 7.6 days which were significantly shorter than those of patients without probiotic. There were significant differences in inpatient days, radiological improvement at day 6 and week 3, and reduction in interleukin-6 levels in those receiving oral probiotic therapy. Although the mortality rate was 5% in the probiotic group, it was 25% in the non-probiotic group. Booster-single strain probiotic bifidobacteria could be an effective treatment strategy for moderate/severe SARS-CoV-2 inpatients to reduce the mortality and length of stay in hospital.
Conclusion Oral booster dose Bifidobacterium animalis subsp. Lactis administration could provide lower mortality, shortening the length of stay in hospital, early radiologic improvement and decrease plasma IL-6 level in moderate/severe SARS-CoV-2 patients. It is still necessary to develop diagnostic strategies to determine the patients to whom this method would be the most applicable. Declaration of Conflicting Interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. ORCID iDs Hüseyin S Bozkurt  https://orcid.org/0000-0003-2097-2950 Ömer Bilen  https://orcid.org/0000-0001-7198-8421
References
Baindara, Chakraborty, Holliday, Oral probiotics in coronavirus disease 2019: connecting the gut-lung axis to viral pathogenesis, inflammation, secondary infection and clinical trials, New Microbes and New Infections
Bozkurt, Denktas, Ozdemir, Charge transport in bifidobacterium animalis subsp.lactis BB-12 under various atmospheres, Open Journal of Applied Sciences
Bozkurt, Kara, A new treatment for ulcerative colitis: intracolonic Bifidobacterium and xyloglucan application, European Journal of Inflammation
Bozkurt, Quigley, The probiotic Bifidobacterium in the management of Coronavirus: A theoretical basis, International Journal of Immunopathology and Pharmacology
Cavalli, Dagna, The right place for IL-1 inhibition in COVID-19, The Lancet Respiratory Medicine
Fung, Liu, The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus, Virology
Grifoni, Valoriani, Cei, Interleukin-6 as prognosticator in patients with COVID-19, The Journal of Infection
Hazan, Stollman, Bozkurt, The missing microbes: bifidobacterium and faecalibacterium depletion and loss of microbiome diversity as potential susceptibility markers for SARS-CoV-2 infection and severity, British Medical Journal
Hou, Jin, Kang, Kim, Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function, Journal of Virology
Jungersen, Wind, Johansen, The science behind the probiotic strain Bifidobacterium animalis subsp. lactis BB-12 ®, Microorganisms
Kong, Cheng, Yu, Induction of autophagy and interleukin 6 secretion in bystander cells: metabolic cooperation for radiation-induced rescue effect?, Journal of Radiation Research
Larsen, Nielsen, Kaestel, Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults, European Journal of Clinical Nutrition
Li, Cheng, Xu, The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients, International Immunopharmacology
Lu, Drug treatment options for the 2019-new coronavirus (2019-nCoV), BioScience Trends
Mahooti, Miri, Abdolalipour, The immunomodulatory effects of probiotics on respiratory viral infections: a hint for COVID-19 treatment?, Microbial Pathogenesis
Rosas, Bräu, Waters, Tocilizumab in hospitalized patients with severe Covid-19 pneumonia, The New England Journal of Medicine
Rozga, Cheng, Handu, Effects of probiotics in conditions or infections similar to COVID-19 on health outcomes: an evidence analysis center scoping review, Journal of the Academy Nutrition and Dietetics
Santacroce, Inchingolo, Topi, Potential beneficial role of probiotics on the outcome of COVID-19 patients: an evolving perspective, Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Sundararaman, Ray, Ravindra, Role of probiotics to combat viral infections with emphasis on COVID-19, Applied Microbiology and Biotechnology
Wong, Lui, Jj, Covid-19 and the digestive system, J ournal of Gastroenterology and Hepatology
Xu, Shi, Wang, Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet Respiratory Medicine
Zhang, Li, Zhan, Analysis of serum cytokines in patients with severe acute respiratory syndrome, Infection and Immunity
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, Lancet
{ 'indexed': { 'date-parts': [[2021, 12, 15]], 'date-time': '2021-12-15T03:58:24Z', 'timestamp': 1639540704367}, 'reference-count': 24, 'publisher': 'SAGE Publications', 'license': [ { 'start': { 'date-parts': [[2021, 1, 1]], 'date-time': '2021-01-01T00:00:00Z', 'timestamp': 1609459200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by-nc/4.0/'}], 'content-domain': {'domain': ['journals.sagepub.com'], 'crossmark-restriction': True}, 'short-container-title': ['Int J Immunopathol Pharmacol'], 'published-print': {'date-parts': [[2021, 1]]}, 'abstract': '<jats:p> Oral booster-single strain probiotic bifidobacteria could be a potential strategy ' 'for SARS-CoV-2. This study aims to evaluate the role of oral probiotic Bifidobacterium on ' 'moderate/severe SARS-CoV-2 inpatients. In this single-center study, we analyzed data of 44 ' 'moderate/severe inpatients with diagnosed COVID-19 in Istanbul Maltepe University Medical ' 'Faculty Hospital, 2020 from 1 November 2020 to 15 December 2020. Clinical and medication ' 'features were compared and analyzed between patients with or without probiotic. In result, 19 ' 'of the 44 patients (43.18%) who were administrated with oral booster-single strain probiotic ' 'were discharged with the median inpatient day of 7.6\xa0days which were significantly shorter ' 'than those of patients without probiotic. There were significant differences in inpatient ' 'days, radiological improvement at day 6 and week 3, and reduction in interleukin-6 levels in ' 'those receiving oral probiotic therapy. Although the mortality rate was 5% in the probiotic ' 'group, it was 25% in the non-probiotic group. Booster-single strain probiotic bifidobacteria ' 'could be an effective treatment strategy for moderate/severe SARS-CoV-2 inpatients to reduce ' 'the mortality and length of stay in hospital. </jats:p>', 'DOI': '10.1177/20587384211059677', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 11, 25]], 'date-time': '2021-11-25T08:14:22Z', 'timestamp': 1637828062000}, 'page': '205873842110596', 'update-policy': 'http://dx.doi.org/10.1177/sage-journals-update-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': ['Oral booster probiotic bifidobacteria in SARS-COV-2 patients'], 'prefix': '10.1177', 'volume': '35', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-2097-2950', 'authenticated-orcid': False, 'given': 'Hüseyin S', 'family': 'Bozkurt', 'sequence': 'first', 'affiliation': [ { 'name': 'Faculty of Medical, Clinic of Gastroenterology, Istanbul Maltepe ' 'University, Istanbul, Turkey'}]}, { 'ORCID': 'http://orcid.org/0000-0001-7198-8421', 'authenticated-orcid': False, 'given': 'Ömer', 'family': 'Bilen', 'sequence': 'additional', 'affiliation': [{'name': 'Faculty of Design, Bursa Technical University, Bursa, Turkey'}]}], 'member': '179', 'published-online': {'date-parts': [[2021, 11, 25]]}, 'reference': [ { 'key': 'bibr1-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/jgh.15047'}, { 'key': 'bibr2-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/2058738420961304'}, { 'key': 'bibr3-20587384211059677', 'volume-title': 'COVID-19 (SARS-CoV-2 infection) guide', 'author': 'Republic Of Turkey Ministry Of Health', 'year': '2020'}, { 'issue': '3', 'key': 'bibr4-20587384211059677', 'first-page': 'S57', 'volume': '158', 'author': 'Bozkurt HS', 'year': '2020', 'journal-title': 'European Journal of Inflammation'}, { 'key': 'bibr5-20587384211059677', 'first-page': '21262832', 'author': 'Hazan S', 'year': '2021', 'journal-title': 'British Medical Journal'}, { 'key': 'bibr6-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.5582/bst.2020.01020'}, { 'key': 'bibr7-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jand.2020.07.016'}, { 'key': 'bibr8-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.micpath.2020.104452'}, { 'key': 'bibr9-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00253-020-10832-4'}, { 'key': 'bibr10-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.virol.2019.05.002'}, { 'key': 'bibr11-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/jrr/rrx101'}, { 'key': 'bibr12-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1128/JVI.00724-14'}, { 'key': 'bibr13-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1128/IAI.72.8.4410-4415.2004'}, { 'key': 'bibr14-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30566-3'}, { 'key': 'bibr15-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213-2600(20)30076-X'}, { 'key': 'bibr16-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jinf.2020.06.008'}, { 'key': 'bibr17-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2028700'}, { 'key': 'bibr18-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213-2600(21)00035-7'}, { 'key': 'bibr19-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2021.107531'}, { 'key': 'bibr20-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.dsx.2020.12.040'}, { 'key': 'bibr21-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/microorganisms2020092'}, { 'key': 'bibr22-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.4236/ojapps.2019.96040'}, { 'key': 'bibr23-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/sj.ejcn.1602450'}, { 'key': 'bibr24-20587384211059677', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.nmni.2021.100837'}], 'container-title': ['International Journal of Immunopathology and Pharmacology'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://journals.sagepub.com/doi/pdf/10.1177/20587384211059677', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://journals.sagepub.com/doi/full-xml/10.1177/20587384211059677', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://journals.sagepub.com/doi/pdf/10.1177/20587384211059677', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 11, 25]], 'date-time': '2021-11-25T08:14:25Z', 'timestamp': 1637828065000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 1]]}, 'references-count': 24, 'alternative-id': ['10.1177/20587384211059677'], 'URL': 'http://dx.doi.org/10.1177/20587384211059677', 'relation': {}, 'ISSN': ['2058-7384', '2058-7384'], 'issn-type': [{'value': '2058-7384', 'type': 'print'}, {'value': '2058-7384', 'type': 'electronic'}], 'subject': ['Pharmacology', 'Immunology', 'Immunology and Allergy'], 'published': {'date-parts': [[2021, 1]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit