Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All sotrovimab studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchSotrovimabSotrovimab (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Real world Effectiveness of Sotrovimab in Preventing COVID-19–related Hospitalisation or Death in Patients Infected with Omicron BA.2

Behzad et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2023.11.029
Dec 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Death/ICU 74% Improvement Relative Risk Sotrovimab  Behzad et al.  EARLY TREATMENT Is early treatment with sotrovimab beneficial for COVID-19? Retrospective 1,180 patients in Bahrain (January - March 2022) Lower death/ICU with sotrovimab (p=0.0015) c19early.org Behzad et al., J. Infection and Public.., Dec 2023 Favorssotrovimab Favorscontrol 0 0.5 1 1.5 2+
Sotrovimab for COVID-19
41st treatment shown to reduce risk in May 2023
 
*, now with p = 0.002 from 25 studies, recognized in 38 countries. Efficacy is variant dependent.
Lower risk for mortality, ICU admission, and hospitalization.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Analysis of 1,180 high-risk COVID-19 outpatients infected with Omicron BA.2 showing lower risk of death or ICU admission with sotrovimab treatment.
Confounding by treatment propensity. This study analyzes a population where only a fraction of eligible patients received the treatment. Patients receiving treatment may be more likely to follow other recommendations, more likely to receive additional care, and more likely to use additional treatments that are not tracked in the data (e.g., nasal/oral hygiene1,2, vitamin D3, etc.) — either because the physician recommending sotrovimab also recommended them, or because the patient seeking out sotrovimab is more likely to be familiar with the efficacy of additional treatments and more likely to take the time to use them. Therefore, these kind of studies may overestimate the efficacy of treatments.
Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.14-6, BA.4, BA.57, XBB.1.9.3, XBB.1.5.24, XBB.2.9, CH.1.18, and no efficacy for BA.29, ХВВ.1.9.1, XBB.1.16, BQ.1.1.45, and CL.18. US EUA has been revoked.
risk of death/ICU, 74.4% lower, HR 0.26, p = 0.001, treatment 569, control 611.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Behzad et al., 4 Dec 2023, retrospective, Bahrain, peer-reviewed, 6 authors, study period 1 January, 2022 - 31 March, 2022. Contact: mqahtani@rcsi-mub.com, dr.abehzad@gmail.com, dr.aamalmohamed@gmail.com, 19202638@rcsi-mub.com, 20202566@rcsi.com, abutler@rcsi.com.
This PaperSotrovimabAll
Real world Effectiveness of Sotrovimab in Preventing COVID-19–related Hospitalisation or Death in Patients Infected with Omicron BA.2
Alwaleed Behzad, Aamal Mohamed, Ahmed Ali, Sara Niinuma, Alexandra E Butler, Manaf Alqahtani
Journal of Infection and Public Health, doi:10.1016/j.jiph.2023.11.029
Background. Laboratory-based evidence indicates that neutralization of the BA.2 (Omicron) variant by sotrovimab is reduced versus previous SARS-CoV-2 variants. Since there is a lack of real-world data, we investigated whether sotrovimab has reduced clinical efficacy against the BA.2 variant. Methods. We performed a prospective cohort study using real-world data from 1180 randomlyselected BA.2 variant-infected patients. Follow-up to study endpoints averaged 29 days. For mild cases (not requiring oxygen-supplementation), primary outcomes were requiring O2supplementation, intensive care unit (ICU) admission or death. For moderate-to-severe COVID-19 cases (requiring oxygen-supplementation other than mechanical ventilation), the primary outcome was ICU admission or death. Results. Patients in the sotrovimab group (n=569) and control patients (n=611) were included. Sotrovimab-treated patients versus controls had reduced risk of death (0.4% vs 6.4%, p<0.001), need for oxygen supplementation (3.5% vs 12.8%, p<0.001) and ICU admission (0.2% vs 4.9%, p<0.001). The adjusted-odds ratio for developing any of these outcomes was 0.090 (95% CI 0.049-0.165, p<0.001). Subgroup analysis of moderate-to-severe sotrovimab-treated patients versus controls revealed reduced mortality (17.7% vs 37.2%, p=0.006) and ICU admission (0.0% vs 37.2%, p<0.001). Adjusted-hazards ratio for death or ICU admission was 0.256 (95% CI 0.111-0.593, p<0.001). Conclusion. Sotrovimab was effective in reducing COVID-19 progression risk in high-risk BA.2 variant-infected patients. This finding may alleviate concerns about its clinical efficacy.
Ethics approval and consent to participate: The study was approved by the National COVID-19 Research Committee and the Bahrain Defence Force Hospital Ethics committee (Study code: CRT-COVID2022-155, approved on January 24, 2022). The study was conducted according to the Declaration of Helsinki, the International Conference on Harmonization Good Clinical Practices guidelines (ICH-GCP E6) and local regulations. All patients enrolled in the study provided written informed consent. Consent for publication: All authors gave their consent for publication. Conflict of interest: None of the authors have any conflict of interest to declare. Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. a Mortality is significantly higher in the moderate-to-severe cases as compared to controls. b Oxygen supplementation was significantly lower in the moderate-to-severe cases as compared to control. c ICU admission was significantly lower in the moderate-to-severe cases as compared to control. d Main outcome of any of the three above was not significantly different between the moderate-to-severe cases and the control. *Significant difference at the level of p<0.05. J o u r n a l P r e -p r o o f
References
Arora, Zhang, Krüger, Rocha, Sidarovich et al., SARS-COV-2 omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies, Cell Host & Microbe
Bruel, Hadjadj, Maes, Planas, Seve et al., Serum neutralization of SARS-COV-2 omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies, Nature Medicine
Cox, Peacock, Harvey, Hughes, Wright et al., SARS-COV-2 variant evasion of monoclonal antibodies based on in vitro studies, Nature Reviews Microbiology
Fiaschi, Dragoni, Schiaroli, Bergna, Rossetti et al., Efficacy of licensed monoclonal antibodies and antiviral agents against the SARS-COV-2 omicron sublineages BA.1 and BA.2, Viruses
Gliga, Luebke, Killer, Gruell, Walker et al., Rapid selection of sotrovimab escape variants in SARS-CoV-2 Omicron infected immunocompromised patients, Clin Infect Dis
Gupta, Gonzalez-Rojas, Juarez, Casal, Moya et al., Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab, N Engl J Med
Iketani, Liu, Guo, Chan, Huang et al., Antibody evasion properties of SARS-CoV-2 Omicron sublineages, Nature
J O U R N A L P R E -P R O O F 10-Zhou, Dcosta, Landau, Tada, Resistance of SARS-COV-2 omicron ba.1 and BA.2 variants to vaccine-elicited Sera and therapeutic monoclonal antibodies, Viruses
J O U R N A L P R E -P R O O F 20-Mazzotta, Lepri, Colavita, Rosati, Lalle et al., Viral load decrease in SARS-CoV-2 BA.1 and BA.2 Omicron sublineages infection after treatment with monoclonal antibodies and direct antiviral agents, J Med Virol
Kawaoka, Uraki, Kiso, Iida, Imai et al., Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA, Res Sq
Martin-Blondel, Marcelin, Soulié, Kaisaridi, Lusivika-Nzinga et al., Sotrovimab to prevent severe COVID-19 in high-risk patients infected with Omicron BA.2, J Infect
Ohashi, Hishiki, Akazawa, Kim, Woo et al., Different efficacies of neutralizing antibodies and antiviral drugs on SARS-COV-2 omicron subvariants, Ba.1 and BA.2, Antiviral Research
Razonable, Tulledge-Scheitel, Hanson, Arndt, Speicher et al., Real-world clinical outcomes of Bebtelovimab and SOTROVIMAB treatment of high-risk persons with coronavirus disease 2019 during the omicron epoch, Open Forum Infectious Diseases
Self, Sandkovsky, Reilly, Vock, Gottlieb et al., Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial, Lancet Infect Dis
Shrestha, Foster, Rawlinson, Tedla, Bull, Evolution of the sars-cov-2 omicron variants BA.1 to Ba.5: Implications for immune escape and transmission, Reviews in Medical Virology
Stadler, Chai, Schlub, Cromer, Polizzotto et al., Determinants of passive antibody efficacy in SARS-CoV-2 infection, medRxiv
Touret, Baronti, Pastorino, Villarroel, Ninove et al., In vitro activity of therapeutic antibodies against SARS-COV-2 omicron Ba.1, Ba.2 and BA.5, Scientific Reports
Wilhelm, Widera, Grikscheit, Toptan, Schenk et al., Limited neutralisation of the SARS-COV-2 omicron subvariants BA.1 and BA.2 by convalescent and Vaccine Serum and monoclonal antibodies, eBioMedicine
Zaqout, Almaslamani, Chemaitelly, Hashim, Ittaman et al., Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-COV-2 in Qatar, International Journal of Infectious Diseases
{ 'indexed': {'date-parts': [[2023, 12, 5]], 'date-time': '2023-12-05T00:24:14Z', 'timestamp': 1701735854453}, 'reference-count': 23, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2023, 12, 1]], 'date-time': '2023-12-01T00:00:00Z', 'timestamp': 1701388800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2023, 11, 30]], 'date-time': '2023-11-30T00:00:00Z', 'timestamp': 1701302400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 12]]}, 'DOI': '10.1016/j.jiph.2023.11.029', 'type': 'journal-article', 'created': {'date-parts': [[2023, 12, 4]], 'date-time': '2023-12-04T17:08:01Z', 'timestamp': 1701709681000}, 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Real world Effectiveness of Sotrovimab in Preventing COVID-19–related Hospitalisation or Death ' 'in Patients Infected with Omicron BA.2', 'prefix': '10.1016', 'author': [ { 'ORCID': 'http://orcid.org/0009-0001-2414-8857', 'authenticated-orcid': False, 'given': 'Alwaleed', 'family': 'Behzad', 'sequence': 'first', 'affiliation': []}, {'given': 'Aamal', 'family': 'Mohamed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ahmed', 'family': 'Ali', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara', 'family': 'Niinuma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandra E', 'family': 'Butler', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1523-0429', 'authenticated-orcid': False, 'given': 'Manaf', 'family': 'Alqahtani', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.jiph.2023.11.029_bib1', 'unstructured': 'Tracking sars-COV-2 variants [Internet]. World Health Organization. ' 'World Health Organization; [cited 21 Nov2022]. Available from: ' 'https://www.who.int/activities/tracking-SARS-CoV-2-variants/'}, { 'key': '10.1016/j.jiph.2023.11.029_bib2', 'article-title': 'SARS-COV-2 variant evasion of monoclonal antibodies based on in vitro ' 'studies', 'author': 'Cox', 'year': '2022', 'journal-title': 'Nature Reviews Microbiology'}, { 'issue': '21', 'key': '10.1016/j.jiph.2023.11.029_bib3', 'doi-asserted-by': 'crossref', 'first-page': '1941', 'DOI': '10.1056/NEJMoa2107934', 'article-title': 'Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody ' 'Sotrovimab', 'volume': '385', 'author': 'Gupta', 'year': '2021', 'journal-title': 'N Engl J Med'}, { 'issue': '5', 'key': '10.1016/j.jiph.2023.11.029_bib4', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/rmv.2381', 'article-title': 'Evolution of the sars‐cov‐2 omicron variants BA.1 to Ba.5: Implications ' 'for immune escape and transmission', 'volume': '32', 'author': 'Shrestha', 'year': '2022', 'journal-title': 'Reviews in Medical Virology'}, { 'key': '10.1016/j.jiph.2023.11.029_bib5', 'article-title': 'Characterization and antiviral susceptibility of SARS-CoV-2 ' 'Omicron/BA.2', 'author': 'Kawaoka', 'year': '2022', 'journal-title': 'Res Sq'}, { 'issue': '6', 'key': '10.1016/j.jiph.2023.11.029_bib6', 'doi-asserted-by': 'crossref', 'first-page': '1297', 'DOI': '10.1038/s41591-022-01792-5', 'article-title': 'Serum neutralization of SARS-COV-2 omicron sublineages BA.1 and BA.2 in ' 'patients receiving monoclonal antibodies', 'volume': '28', 'author': 'Bruel', 'year': '2022', 'journal-title': 'Nature Medicine'}, { 'key': '10.1016/j.jiph.2023.11.029_bib7', 'doi-asserted-by': 'crossref', 'article-title': 'Antibody evasion properties of SARS-CoV-2 Omicron sublineages', 'author': 'Iketani', 'year': '2022', 'journal-title': 'Nature.', 'DOI': '10.1038/s41586-022-04594-4'}, { 'issue': '1', 'key': '10.1016/j.jiph.2023.11.029_bib8', 'article-title': 'In vitro activity of therapeutic antibodies against SARS-COV-2 omicron ' 'Ba.1, Ba.2 and BA.5', 'volume': '12', 'author': 'Touret', 'year': '2022', 'journal-title': 'Scientific Reports'}, { 'key': '10.1016/j.jiph.2023.11.029_bib9', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2022.105372', 'article-title': 'Different efficacies of neutralizing antibodies and antiviral drugs on ' 'SARS-COV-2 omicron subvariants, Ba.1 and BA.2', 'volume': '205', 'author': 'Ohashi', 'year': '2022', 'journal-title': 'Antiviral Research'}, { 'issue': '6', 'key': '10.1016/j.jiph.2023.11.029_bib10', 'doi-asserted-by': 'crossref', 'first-page': '1334', 'DOI': '10.3390/v14061334', 'article-title': 'Resistance of SARS-COV-2 omicron ba.1 and BA.2 variants to ' 'vaccine-elicited Sera and therapeutic monoclonal antibodies', 'volume': '14', 'author': 'Zhou', 'year': '2022', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.jiph.2023.11.029_bib11', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ebiom.2022.104158', 'article-title': 'Limited neutralisation of the SARS-COV-2 omicron subvariants BA.1 and ' 'BA.2 by convalescent and Vaccine Serum and monoclonal antibodies', 'volume': '82', 'author': 'Wilhelm', 'year': '2022', 'journal-title': 'eBioMedicine'}, { 'issue': '8', 'key': '10.1016/j.jiph.2023.11.029_bib12', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.chom.2022.04.017', 'article-title': 'SARS-COV-2 omicron sublineages show comparable cell entry but ' 'differential neutralization by therapeutic antibodies', 'volume': '30', 'author': 'Arora', 'year': '2022', 'journal-title': 'Cell Host & Microbe'}, { 'issue': '7', 'key': '10.1016/j.jiph.2023.11.029_bib13', 'doi-asserted-by': 'crossref', 'first-page': '1374', 'DOI': '10.3390/v14071374', 'article-title': 'Efficacy of licensed monoclonal antibodies and antiviral agents against ' 'the SARS-COV-2 omicron sublineages BA.1 and BA.2', 'volume': '14', 'author': 'Fiaschi', 'year': '2022', 'journal-title': 'Viruses.'}, { 'key': '10.1016/j.jiph.2023.11.029_bib14', 'unstructured': 'U.S. Food and Drug Administration. Fact Sheet For Healthcare Providers ' 'Emergency Use Authorization (EUA) Of Sotrovimab [Internet].2022 [Updated ' 'March 2022, Cited 20 Oct 2022]. Available from: ' 'https://www.fda.gov/media/149534/download'}, { 'key': '10.1016/j.jiph.2023.11.029_bib15', 'doi-asserted-by': 'crossref', 'first-page': '96', 'DOI': '10.1016/j.ijid.2022.09.023', 'article-title': 'Effectiveness of the neutralizing antibody sotrovimab among high-risk ' 'patients with mild-to-moderate SARS-COV-2 in Qatar', 'volume': '124', 'author': 'Zaqout', 'year': '2022', 'journal-title': 'International Journal of Infectious Diseases'}, { 'issue': '10', 'key': '10.1016/j.jiph.2023.11.029_bib16', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/ofid/ofac411', 'article-title': 'Real-world clinical outcomes of Bebtelovimab and SOTROVIMAB treatment ' 'of high-risk persons with coronavirus disease 2019 during the omicron ' 'epoch', 'volume': '9', 'author': 'Razonable', 'year': '2022', 'journal-title': 'Open Forum Infectious Diseases'}, { 'key': '10.1016/j.jiph.2023.11.029_bib17', 'unstructured': 'F.D.A. Coronavirus (COVID-19) Update: FDA Authorizes Additional ' 'Monoclonal Antibody for Treatment of COVID-19 [Internet]. U.S. Food and ' 'Drug Administration; 2021 [cited 2022 Nov 21]. Available from: ' 'https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-additional-monoclonal-antibody-treatment-covid-19'}, { 'issue': '4', 'key': '10.1016/j.jiph.2023.11.029_bib18', 'doi-asserted-by': 'crossref', 'first-page': 'e104', 'DOI': '10.1016/j.jinf.2022.06.033', 'article-title': 'Sotrovimab to prevent severe COVID-19 in high-risk patients infected ' 'with Omicron BA.2', 'volume': '85', 'author': 'Martin-Blondel', 'year': '2022', 'journal-title': 'J Infect'}, { 'issue': '5', 'key': '10.1016/j.jiph.2023.11.029_bib19', 'doi-asserted-by': 'crossref', 'first-page': '622', 'DOI': '10.1016/S1473-3099(21)00751-9', 'article-title': 'Efficacy and safety of two neutralising monoclonal antibody therapies, ' 'sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with ' 'COVID-19 (TICO): a randomised controlled trial', 'volume': '22', 'author': 'Self', 'year': '2022', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1016/j.jiph.2023.11.029_bib20', 'unstructured': 'Mazzotta V., Cozzi Lepri A., Colavita F., Rosati S., Lalle E., Cimaglia ' 'C., et al. Viral load decrease in SARS-CoV-2 BA.1 and BA.2 Omicron ' 'sublineages infection after treatment with monoclonal antibodies and ' 'direct antiviral agents. J Med Virol. 10.1002/jmv.28186'}, { 'key': '10.1016/j.jiph.2023.11.029_bib21', 'doi-asserted-by': 'crossref', 'unstructured': 'Stadler E., Chai K.L., Schlub T.E., Cromer D., Polizzotto M.N., Kent ' 'S.J., et al. Determinants of passive antibody efficacy in SARS-CoV-2 ' 'infection. medRxiv. 2022 Aug 4;', 'DOI': '10.1101/2022.03.21.22272672'}, { 'key': '10.1016/j.jiph.2023.11.029_bib22', 'unstructured': 'Gliga S., Luebke N., Killer A., Gruell H., Walker A., Dilthey A.T., et ' 'al. Rapid selection of sotrovimab escape variants in SARS-CoV-2 Omicron ' 'infected immunocompromised patients. Clin Infect Dis. ' '10.1093/cid/ciac802'}, { 'key': '10.1016/j.jiph.2023.11.029_bib23', 'unstructured': 'NHRA. Bahrain COVID-19 national protocols. [Internet]. National Health ' 'Regulatory authority Bahrain; 2020 [cited 2020 Jan 07]. Available from: ' 'https://www.nhra.bh/Media/Announcement/MediaHandler/GenericHandler/documents/Announcements/NHRA_News_MOH%20ALERT_Bahrain%20COVID-19%20National%20Protocols_20200701.pdf'}], 'container-title': 'Journal of Infection and Public Health', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1876034123004355?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1876034123004355?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2023, 12, 4]], 'date-time': '2023-12-04T17:08:34Z', 'timestamp': 1701709714000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1876034123004355'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 12]]}, 'references-count': 23, 'alternative-id': ['S1876034123004355'], 'URL': 'http://dx.doi.org/10.1016/j.jiph.2023.11.029', 'relation': {}, 'ISSN': ['1876-0341'], 'subject': [ 'Infectious Diseases', 'Public Health, Environmental and Occupational Health', 'General Medicine'], 'container-title-short': 'Journal of Infection and Public Health', 'published': {'date-parts': [[2023, 12]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Real world Effectiveness of Sotrovimab in Preventing COVID-19–related ' 'Hospitalisation or Death in Patients Infected with Omicron BA.2', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Journal of Infection and Public Health', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jiph.2023.11.029', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2023 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin ' 'Abdulaziz University for Health Sciences.', 'name': 'copyright', 'label': 'Copyright'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit