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The Effect of Weekly 50,000 IU Vitamin D3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency

Bader et al., Nutrients, doi:10.3390/nu15051188
Feb 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 111 treatments. c19early.org
RCT 100 patients in Jordan, showing that high-dose cholecalciferol (50,000 IU/week) significantly increased IL-6, indicating that high weekly doses could have a negative effect for cytokine storm with COVID-19. Other studies have found no significant difference in IL-61,2.
Bader et al., 27 Feb 2023, Jordan, peer-reviewed, 10 authors, study period October 2020 - December 2020. Contact: m_abusamak@asu.edu.jo (corresponding author).
This PaperVitamin DAll
The Effect of Weekly 50,000 IU Vitamin D3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency
Dana A Bader, Anas Abed, Beisan A Mohammad, Ahmad Aljaberi, Ahmad Sundookah, Maha Habash, Ahmad R Alsayed, Mohammad Abusamak, Sami Al-Shakhshir, Mahmoud Abu-Samak
Nutrients, doi:10.3390/nu15051188
Abu-Samak, M. The Effect of Weekly 50,000 IU Vitamin D 3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency.
Conflicts of Interest: The authors declare no conflict of interest.
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Interleukin-6 (IL-6), interleukin-1β (IL-1β), ' 'interleukin-10 (IL-10), tumor necrotic factor-α (TNF-α), and leptin were measured in serum at ' 'baseline and 10 weeks (wash out: 2 weeks). Our results revealed that vitamin D3 ' 'supplementation significantly increased the serum levels of 25OHD, IL-6, IL-10, IL-1β, and ' 'leptin compared with baseline. In contrast, the serum level of TNF-α insignificantly ' 'increased in the group receiving vitamin D3 supplementation. 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