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The Effect of Weekly 50,000 IU Vitamin D3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency

Bader et al., Nutrients, doi:10.3390/nu15051188
Feb 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
RCT 100 patients in Jordan, showing that high-dose cholecalciferol (50,000 IU/week) significantly increased IL-6, indicating that high weekly doses could have a negative effect for cytokine storm with COVID-19. Other studies have found no significant difference in IL-61,2.
Bader et al., 27 Feb 2023, Jordan, peer-reviewed, 10 authors, study period October 2020 - December 2020. Contact: m_abusamak@asu.edu.jo (corresponding author).
This PaperVitamin DAll
The Effect of Weekly 50,000 IU Vitamin D3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency
Dana A Bader, Anas Abed, Beisan A Mohammad, Ahmad Aljaberi, Ahmad Sundookah, Maha Habash, Ahmad R Alsayed, Mohammad Abusamak, Sami Al-Shakhshir, Mahmoud Abu-Samak
Nutrients, doi:10.3390/nu15051188
Abu-Samak, M. The Effect of Weekly 50,000 IU Vitamin D 3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency.
Conflicts of Interest: The authors declare no conflict of interest.
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Interleukin-6 (IL-6), interleukin-1β (IL-1β), ' 'interleukin-10 (IL-10), tumor necrotic factor-α (TNF-α), and leptin were measured in serum at ' 'baseline and 10 weeks (wash out: 2 weeks). Our results revealed that vitamin D3 ' 'supplementation significantly increased the serum levels of 25OHD, IL-6, IL-10, IL-1β, and ' 'leptin compared with baseline. In contrast, the serum level of TNF-α insignificantly ' 'increased in the group receiving vitamin D3 supplementation. 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Cytokine ' 'and anti-cytokine interventions', 'volume': '19', 'author': 'Jamilloux', 'year': '2020', 'journal-title': 'Autoimmun. Rev.'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '19', 'DOI': '10.1016/j.immuni.2020.06.017', 'article-title': 'Cytokine Storms: Understanding COVID-19', 'volume': '53', 'author': 'Mangalmurti', 'year': '2020', 'journal-title': 'Immunity'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'first-page': '1449', 'DOI': '10.1517/14712598.7.9.1449', 'article-title': 'The role of cathelicidin and defensins in pulmonary inflammatory ' 'diseases', 'volume': '7', 'author': 'Herr', 'year': '2007', 'journal-title': 'Expert Opin. Biol. Ther.'}, { 'key': 'ref_4', 'doi-asserted-by': 'crossref', 'unstructured': 'Grant, W.B., Lahore, H., McDonnell, S.L., Baggerly, C.A., French, C.B., ' 'Aliano, J.L., and Bhattoa, H.P. (2020). Evidence that Vitamin D ' 'Supplementation Could Reduce Risk of Influenza and COVID-19 Infections ' 'and Deaths. 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