The Effect of Weekly 50,000 IU Vitamin D3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency
Dana A Bader, Anas Abed, Beisan A Mohammad, Ahmad Aljaberi, Ahmad Sundookah, Maha Habash, Ahmad R Alsayed, Mohammad Abusamak, Sami Al-Shakhshir, Mahmoud Abu-Samak
Nutrients, doi:10.3390/nu15051188
Abu-Samak, M. The Effect of Weekly 50,000 IU Vitamin D 3 Supplements on the Serum Levels of Selected Cytokines Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency.
Conflicts of Interest: The authors declare no conflict of interest.
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'abstract': '<jats:p>This research aimed to evaluate the effects of high-dose cholecalciferol (VD3) '
'supplements (50,000 IU/week) on selected circulating cytokines associated with cytokine '
'storms in adults with vitamin D deficiency. This clinical trial, based in Jordan, included 50 '
'participants receiving vitamin D3 supplements (50,000 IU/week) for 8 weeks; the exact number '
'was assigned to the control group. Interleukin-6 (IL-6), interleukin-1β (IL-1β), '
'interleukin-10 (IL-10), tumor necrotic factor-α (TNF-α), and leptin were measured in serum at '
'baseline and 10 weeks (wash out: 2 weeks). Our results revealed that vitamin D3 '
'supplementation significantly increased the serum levels of 25OHD, IL-6, IL-10, IL-1β, and '
'leptin compared with baseline. In contrast, the serum level of TNF-α insignificantly '
'increased in the group receiving vitamin D3 supplementation. Although the observations of '
'this trial may refer to a potential negative effect of VD3 supplementation during cytokine '
'storms, further trials are required to clarify the potential benefits of VD3 supplement '
'during cytokine storms.</jats:p>',
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'Involved in Cytokine Storm: A Randomized Clinical Trial in Adults with Vitamin D Deficiency',
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