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Anticoagulant Use in COVID-19 Patients: A Longitudinal Study From Zanjan, Iran

Azimi Pirsaraei et al., Cureus, doi:10.7759/cureus.66798
Aug 2024  
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Mortality -163% Improvement Relative Risk Lopinavir/ritonavir  Azimi Pirsaraei et al.  LATE TREATMENT Is late treatment with lopinavir/ritonavir beneficial for COVID-19? Retrospective 831 patients in Iran (March - June 2020) Higher mortality with lopinavir/ritonavir (p=0.000012) c19early.org Azimi Pirsaraei et al., Cureus, August 2024 Favorslopinavir/ritonavir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 831 hospitalized COVID-19 patients showing higher mortality with lopinavir/ritonavir treatment in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers aspirin and HCQ.
risk of death, 163.4% higher, RR 2.63, p < 0.001, treatment 36 of 204 (17.6%), control 42 of 627 (6.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Azimi Pirsaraei et al., 13 Aug 2024, retrospective, Iran, peer-reviewed, mean age 57.2, 5 authors, study period 20 March, 2020 - 20 June, 2020. Contact: zmed1996@gmail.com.
This PaperMiscellaneousAll
Anticoagulant Use in COVID-19 Patients: A Longitudinal Study From Zanjan, Iran
Vanoushe Azimi Pirsaraei, Manizhe Jozpanahi, Koorosh Kamali, Leila Hamzeloo, Seyedeh Pegah Saeid
Cureus, doi:10.7759/cureus.66798
Background The mortality and morbidity of thrombotic events in patients with coronavirus disease 2019 (COVID-19) are increasing worldwide. The clinical impact of prophylactic anticoagulation regimens among these patients in Iran remains unclear. This study aimed to evaluate the use of prophylactic anticoagulants and outcomes among COVID-19 patients admitted to a tertiary referral hospital. Methodology Patients diagnosed with COVID-19 and hospitalized between March 20 and June 20, 2020, were included in this longitudinal study after obtaining informed consent. Demographic and clinical data were collected from the hospital information system and medical records. Outcomes during this period were also evaluated. The data were entered into the preparation checklist and analyzed using SPSS version 24 software (IBM Corp., Armonk, NY, USA), employing chi-square, Fisher's exact, and Mann-Whitney U tests. Results Of the 831 enrolled patients, 51.9% were female, and 10.6% needed to be admitted to the intensive care unit (ICU). The mean age of the patients was 57.16 ± 17.32 years, and the mortality rate was estimated to be 9.4%. Mortality rates were significantly higher at older ages, in men, patients with ICU admission, severe pulmonary involvement, malignancy, airway obstruction, ischemic heart disease, and previous cerebrovascular accidents. ICU admission and mortality were statistically significantly higher in those who received concurrent prophylactic anticoagulants and aspirin than in other individuals. Conclusions Our study demonstrated that administering prophylactic aspirin with or without anticoagulant agents in COVID-19 patients did not reduce mortality rates or ICU transfers. However, it is worth noting that anticoagulant prescription was associated with a decrease in ICU admissions, which could potentially alleviate the significantly higher mortality rates observed among ICU patients in this study. Further research is needed to explore the potential benefits of anticoagulants in COVID-19 treatment.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work. In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. Acquisition, analysis, or interpretation of data
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Late treatment
is less effective
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