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Recent:   

Virgin coconut oil (VCO) supplementation relieves symptoms and inflammation among COVID-19 positive adults: a single-blind randomized trial

Angeles-Agdeppa et al., Journal of Nutritional Science, doi:10.1017/jns.2023.118
Jan 2024  
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Recovery 47% Improvement Relative Risk Recovery time 38% no CI Viral clearance, endline 33% Viral clearance, midline 20% VCO  Angeles-Agdeppa et al.  LATE TREATMENT  RCT Is late treatment with VCO beneficial for COVID-19? RCT 76 patients in Philippines (August - November 2021) Improved recovery with VCO (not stat. sig., p=0.13) c19early.org Angeles-Agdeppa et al., J. Nutritional.., Jan 2024 FavorsVCO Favorscontrol 0 0.5 1 1.5 2+
RCT 76 hospitalized mild-to-moderate COVID-19 patients in the Philippines showing faster resolution of symptoms with virgin coconut oil (VCO) treatment, without statistical significance.
risk of no recovery, 46.7% lower, RR 0.53, p = 0.13, treatment 8 of 38 (21.1%), control 15 of 38 (39.5%), NNT 5.4, mid-recovery, day 7.
recovery time, 37.5% lower, relative time 0.62, treatment 38, control 38.
risk of no viral clearance, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 38 (5.3%), control 3 of 38 (7.9%), NNT 38, endline.
risk of no viral clearance, 20.0% lower, RR 0.80, p = 0.63, treatment 12 of 38 (31.6%), control 15 of 38 (39.5%), NNT 13, midline.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Angeles-Agdeppa et al., 23 Jan 2024, Single Blind Randomized Controlled Trial, Philippines, peer-reviewed, mean age 43.5, 4 authors, study period August 2021 - November 2021. Contact: iangelesagdeppa@yahoo.com.ph.
This PaperMiscellaneousAll
Virgin coconut oil (VCO) supplementation relieves symptoms and inflammation among COVID-19 positive adults: a single-blind randomized trial
Imelda Angeles-Agdeppa, Jacus S Nacis, Fabian M Dayrit, Keith V Tanda
Journal of Nutritional Science, doi:10.1017/jns.2023.118
A clinical study conducted in 2020 showed that virgin coconut oil (VCO) has been found effective in the rapid relief of COVID-19 symptoms and normalization of the C-reactive protein (CRP) concentration among probable and suspected cases of COVID-19. This present study aimed to validate those results and to evaluate the effects of VCO among COVID-19 patients through a 28-day randomized, single-blind trial conducted among 76 SARS-CoV-2 RT-PCR (reverse transcription-polymerase chain report)-confirmed adults, with VCO given as a COVID-19 adjunct therapy. The results showed that VCO recipients were free from symptoms and had normal CRP concentrations by day 14. In comparison, participants in the control group reported relief from signs and symptoms on day 23, with normal CRP concentrations on day 25. This second study bolsters the use of VCO as an effective adjunct therapy for COVID-19-positive patients showing mild-to-moderate symptoms.
The Philippine Coconut Authority (PCA) provided the VCOs used for the study. Valenzuela City Emergency Hospital provided meals to the hospitalized patients. The funders had no role in the design, analysis, or writing of this article. The study was carried out following the Declaration of Helsinki, guided by the Council for International Organizations of Medical Sciences Ethical Guidelines for Biomedical Research Involving Human Subjects and the National Guidelines for Biomedical/Behavioral Research. The study was approved by the FNRI Institutional Ethics Review Committee (FIERC-2020-017). Imelda Angeles-Agdeppa conceptualized, designed, and supervised the implementation, acquired funds for the study, interpreted the data, drafted the initial manuscript, and approved the final manuscript as submitted. Jacus S. Nacis assisted in the implementation of the study and contributed to drafting the initial manuscript, Fabian M. Dayrit, contributed significant technical assistance, and reviewed and edited the initial manuscript. Keith V. Tanda conducted data analysis under the guidance of the primary author. All authors have read and agreed to the published version of the manuscript. The authors declare that there is no conflict of interest regarding the publication of this paper.
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Republic of the Philppines Department of Health Office of the ' 'Secretary. Administrative Order No. 2020-0013: Revised Administrative ' 'Order No. 2020-0012 “Guidelines for the Inclusion of the Coronavirus ' 'Disease 2019 (COVID-19) in the List of Notifiable Diseases for Mandatory ' 'Reporting to the Department of Health” dated March 17, 2020;1–22.'}, { 'key': 'S2048679023001180_ref20', 'unstructured': '20. Republic of the Philippines Department of Health Office of the ' 'Secretary. Interim Guidelines on the Preparation and Handling of Food in ' 'Temporary Treatment and Monitoring Facilities for COVID-19 Patients. ' '2020;1–4.'}, { 'key': 'S2048679023001180_ref31', 'doi-asserted-by': 'crossref', 'first-page': '507', 'DOI': '10.1016/S0140-6736(20)30211-7', 'article-title': 'Epidemiological and clinical characteristics of 99 cases of 2019 novel ' 'coronavirus pneumonia in Wuhan, China: a descriptive study', 'volume': '395', 'author': 'Chen', 'year': '2020', 'journal-title': 'Lancet.'}, { 'key': 'S2048679023001180_ref46', 'unstructured': '46. PGC SARS-CoV-2 Bulletin No. 3: 23 newly reported SARS-CoV-2 genome ' 'sequences from the Philippines support PGC’s previously hypothesized ' 'viral entry routes and waves of transmission. Retrieved December 28, ' '2022, from ' 'https://pgc.up.edu.ph/pgc-sars-cov-2-bulletin-no-3-23-newly-reported-sars-cov-2-genome-sequences-from-the-philippines-support-pgcs-previously-hypothesized-viral-entry-routes-and-waves-of-transmission/'}, { 'key': 'S2048679023001180_ref18', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/s41598-021-93260-2', 'article-title': 'Understanding protection from SARS-CoV-2 using metabolomics', 'volume': '11', 'author': 'Barberis', 'year': '2021', 'journal-title': 'Sci Rep.'}, { 'key': 'S2048679023001180_ref44', 'doi-asserted-by': 'crossref', 'first-page': '4', 'DOI': '10.21037/jlpm-20-98', 'article-title': 'Altered lipid profile in patients with COVID-19 infection', 'volume': '6', 'author': 'Roccaforte', 'year': '2021', 'journal-title': 'J Lab Precis Med.'}, { 'key': 'S2048679023001180_ref23', 'first-page': '1', 'article-title': 'C-reactive protein concentrations as a marker of inflammation or ' 'infection for interpreting biomarkers of micronutrient status', 'year': '2014', 'journal-title': 'Vitamin Miner Nutr Inf Syst.'}], 'container-title': 'Journal of Nutritional Science', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2048679023001180', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 1, 23]], 'date-time': '2024-01-23T09:44:07Z', 'timestamp': 1706003047000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.cambridge.org/core/product/identifier/S2048679023001180/type/journal_article'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024]]}, 'references-count': 47, 'alternative-id': ['S2048679023001180'], 'URL': 'http://dx.doi.org/10.1017/jns.2023.118', 'relation': {}, 'ISSN': ['2048-6790'], 'subject': [], 'container-title-short': 'J Nutr Sci', 'published': {'date-parts': [[2024]]}, 'article-number': 'e5'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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