Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, randomized pilot clinical trial (povidone-iodine in COVID-19 management)

{ 'indexed': {'date-parts': [[2024, 3, 2]], 'date-time': '2024-03-02T00:28:52Z', 'timestamp': 1709339332222}, 'reference-count': 36, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 3, 1]], 'date-time': '2024-03-01T00:00:00Z', 'timestamp': 1709251200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 3, 1]], 'date-time': '2024-03-01T00:00:00Z', 'timestamp': 1709251200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Objectives/Hypothesis</jats:title>\n' ' <jats:p>To assess the efficacy of 0.23% povidone-iodine (PVP-I) nasal rinses ' 'and mouth washes on detectability of the coronavirus disease 2019 (COVID-19) virus and cycle ' 'threshold (Ct) values in nasopharyngeal swabs.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Study design</jats:title>\n' ' <jats:p>This was an open-label, prospective, randomized, placebo-controlled ' 'clinical trial.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Setting</jats:title>\n' ' <jats:p>The study was conducted in King Saud University Medical City, Riyadh, ' 'Saudi Arabia, from August 2021 to July 2022.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Participants diagnosed with SARS-CoV-2 were randomly assigned to one ' 'of three groups, with participants receiving either 0.23% PVP-I, 0.9% normal saline (NS) ' 'nasal rinses and mouth washes, or no intervention (control group). Nasopharyngeal swabs were ' 'taken 4, 8, 12, and 18 days after the first swab to measure the detectability of the virus ' 'and the Ct.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>A total of 19 participants were involved in this study. The mean ' 'viral survival was 9.8, 12, and 12.6 days for the PVP-I, NS, and control groups, ' 'respectively, with a statistically significant difference (<jats:italic>p</jats:italic>\u2009' '=\u20090.046). The Ct mean values were 23\u2009±\u20093.4, 23.5\u2009±\u20096.3, and ' '26.3\u2009±\u20095.9 at the time of recruitment and 25.2\u2009±\u20093.5, 15\u2009±\u2009' '11.7, and 26.9\u2009±\u20096.4 after 4 days for the PVP-I, NS, and control groups, ' 'respectively.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>When used continuously at a concentration of 0.23%, PVP-I showed ' 'promising results in terms of decreasing the pandemic burden by reducing the period of ' 'infectiousness and viral load. However, the use of PVP-I did not result in significantly ' 'different changes in the quality-of-life parameters in recently vaccinated and mild COVID-19 ' 'patients.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s12879-024-09137-y', 'type': 'journal-article', 'created': {'date-parts': [[2024, 3, 1]], 'date-time': '2024-03-01T10:02:24Z', 'timestamp': 1709287344000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, ' 'randomized pilot clinical trial (povidone-iodine in COVID-19 management)', 'prefix': '10.1186', 'volume': '24', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-1236-2098', 'authenticated-orcid': False, 'given': 'Saad', 'family': 'Alsaleh', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4754-0293', 'authenticated-orcid': False, 'given': 'Ahmed', 'family': 'Alhussien', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-2495-7523', 'authenticated-orcid': False, 'given': 'Abduljabbar', 'family': 'Alyamani', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-9655-9698', 'authenticated-orcid': False, 'given': 'Fahad', 'family': 'Alhussain', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2074-8916', 'authenticated-orcid': False, 'given': 'Ali', 'family': 'Alhijji', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5425-9531', 'authenticated-orcid': False, 'given': 'Khalifa', 'family': 'Binkhamis', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-5075-7392', 'authenticated-orcid': False, 'given': 'Anas', 'family': 'Khan', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3116-6559', 'authenticated-orcid': False, 'given': 'Amin', 'family': 'Javer', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-4646-7488', 'authenticated-orcid': False, 'given': 'Fatimah S.', 'family': 'Alshahrani', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 3, 1]]}, 'reference': [ { 'key': '9137_CR1', 'unstructured': 'WHO Director-General’s remarks at the media briefing. on 2019-nCoV on 11 ' 'February 2020 [Internet]. 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' 'https://doi.org/10.1001/jamanetworkopen.2022.35837.', 'DOI': '10.1001/jamanetworkopen.2022.35837'}], 'container-title': 'BMC Infectious Diseases', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12879-024-09137-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s12879-024-09137-y/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12879-024-09137-y.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 3, 1]], 'date-time': '2024-03-01T10:02:52Z', 'timestamp': 1709287372000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09137-y'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 3, 1]]}, 'references-count': 36, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'alternative-id': ['9137'], 'URL': 'http://dx.doi.org/10.1186/s12879-024-09137-y', 'relation': {}, 'ISSN': ['1471-2334'], 'subject': ['Infectious Diseases'], 'container-title-short': 'BMC Infect Dis', 'published': {'date-parts': [[2024, 3, 1]]}, 'assertion': [ { 'value': '6 October 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '14 February 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '1 March 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The study was approved by the King Saud University Institutional Review Board ' 'and the Saudi Food and Drug Authority Clinical Trial Unit. All patients who met ' 'the inclusion criteria signed a written informed consent form that mentioned ' 'possible risks and benefits associated with the intervention.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '271'}