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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk Ventilation 67% Oxygen time 46% Recovery time, dyspnea 36% Recovery time, fever 39% Recovery time, cough 30% Time to viral- 45% Hydrogen Peroxide  HOPE in COVID-19  LATE TREATMENT  DB RCT Is late treatment with hydrogen peroxide beneficial for COVID-19? Double-blind RCT 40 patients in India Lower need for oxygen therapy (p<0.0001) and faster recovery (p<0.0001) c19early.org Agrawal et al., J. South Asian Federat.., Apr 2022 Favors hydrogen peroxide Favors control

Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients

Agrawal et al., Journal of South Asian Federation of Obstetrics and Gynaecology, doi:10.5005/jp-journals-10006-1986, HOPE in COVID-19, CTRI/2020/08/027038
Apr 2022  
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RCT 40 patients in India, showing improved recovery with nebulized hydrogen peroxide.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of death, 66.7% lower, RR 0.33, p = 0.60, treatment 1 of 20 (5.0%), control 3 of 20 (15.0%), NNT 10.0.
risk of mechanical ventilation, 66.7% lower, RR 0.33, p = 0.60, treatment 1 of 20 (5.0%), control 3 of 20 (15.0%), NNT 10.0.
oxygen time, 46.3% lower, relative time 0.54, p < 0.001, treatment mean 4.74 (±1.62) n=19, control mean 8.82 (±1.59) n=17.
recovery time, 35.7% lower, relative time 0.64, p < 0.001, treatment mean 4.58 (±1.12) n=19, control mean 7.12 (±1.05) n=17, dyspnea.
recovery time, 38.9% lower, relative time 0.61, p < 0.001, treatment mean 2.84 (±1.01) n=19, control mean 4.65 (±1.22) n=17, fever.
recovery time, 29.8% lower, relative time 0.70, p = 0.001, treatment mean 4.79 (±1.84) n=19, control mean 6.82 (±1.51) n=17, cough.
time to viral-, 45.2% lower, relative time 0.55, p < 0.001, treatment mean 5.16 (±1.21) n=19, control mean 9.41 (±1.97) n=17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Agrawal et al., 5 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, mean age 47.0, 8 authors, trial CTRI/2020/08/027038 (HOPE in COVID-19).
Contact: dr.akhilpratapsingh1@gmail.com.
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Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients
Arti Agrawal, Prabhat Agrawal, Ashish Gautam, Nikhil Pursnani, Prashant Gupta, Akhil Pratap Singh, Ruchika Garg, Ajeet Singh Chahar
Journal of South Asian Federation of Obstetrics and Gynaecology, doi:10.5005/jp-journals-10006-1986
Importance: Given the high mortality and cost of health care, especially in isolation settings, the idea of using nebulized hydrogen peroxide may play a very significant role in inactivation of coronavirus, thus reducing the infectivity period leading to reduced requirement of isolation and improving morbidity and mortality in people suffering with coronavirus disease-2019 (COVID-2019). Aim and objective: Objective of this study was to determine the efficiency of nebulized hydrogen peroxide (H 2 O 2 ) in reducing the viral load and disease severity of patients suffering with COVID-19. Design: Double-blinded randomized control trial. HOPE in COVID-19 study. Setting: Tertiary care COVID hospital (single center). Participants: Moderate sick COVID-19-positive patients were included in the study after they qualified the inclusion criteria. Intervention: Patients were nebulized using 1 mL of ozonized H 2 O 2 after diluting with 4 mL of normal saline three times a day for 5 days. The control group was nebulized with normal saline only. Main outcome: Outcome was assessed for reduction in oxygen requirement (number of days on oxygen), symptoms resolution (dyspnea, cough, and fever), and number of days it took to be RT-PCR negative for COVID-19. Results: The early data from trial showed promising trends toward a better outcome. The study showed that in the case group who were nebulized with hydrogen peroxide resulted in better outcome in terms of parameters assessed in the study and the differences from the control group were statistically significant (p ≤0.001, CI 95%). Outcome in the form of mortality (odds ratio 0.29, 95% CI 0.02-3.14, p = 0.31, z = 1.007) was statistically insignificant. The number needed to treat for our study was 10.
References
Alamdari, Moghaddam, Amini, Application of Methylene Blue-Vitamin C -N-Acetyl Cysteine for Treatment of Critically Ill COVID-19 Patients, doi:10.1016/j.ejphar.2020.173494
Amanna, Raué, Slifka, Development of a New Hydrogen Peroxide-Based Vaccine Platform, Nat Med, doi:10.1038/nm.2763
Brennecke, Villar, Wang, Is Inhaled Furosemide a Potential Therapeutic for COVID-19?, Am J Med Sci, doi:10.1016/j.amjms.2020.05.044
Carr, The Anti-inflammatory Action of Heparin: Heparin as an Antagonist Tohistamine, Bradykinin and Prostaglandin E1, Thromb Res, doi:10.1016/0049-3848(79)90097-5
Caruso, Prete, Lazzarino, Might Hydrogen Peroxide Reduce the Hospitalization Rate and Complications of SARS-CoV-2 Infection?, Infect Control HospEpidemiol, doi:10.1017/ice.2020.170
Favero, Chemical Disinfection of Medical and Surgical Materials
Foulon, Preparing for ASFv: an 'enveloped virus
Fox, Kosikowski, Heat-treated and Hydrogen Peroxide Treated Milks for Ched-dar Cheese, J Dairy Sci
Huang, Zhang, Zhang, Rapid Asymptomatic Transmission of COVID-19 During the Incubation Period Demonstrating Strong Infectivity in a Cluster of Youngsters Aged 16-23 Years Outside Wuhan and Characteristics of Young Patients with COVID-19: A Prospective Contact-Tracing Study, J Infect, doi:10.1016/j.jinf.2020.03.006
Kampf, Todt, Pfaender, Persistence of Coronaviruses on Inanimate Surfaces and Their Inactivation with Biocidal Agents, J Hosp Infect, doi:10.1016/j.jhin.2020.01.022
Klapes, Vesley, Vapor-phase Hydrogen Peroxide as a Surface Decontaminant and Sterilant, Appl Environ Microbiol
Koenig, Norgard-Sumnicht, Linhardt, Differential Interactions of Heparin and Heparan Sulfate Glycosaminoglycans with the Selectins. Implications for the Use of Unfractionated and Low Molecular Weightheparins as Therapeutic Agents, J Clin Invest
Lansbury, Lim, Baskaran, Co-infections in People with COVID-19: A Systematic Review and Meta-analysis, J Infect, doi:10.1016/j.jinf.2020.05.046
Leconte, Ferrant, Dory, Validated Methods of Cough Assessment: A Systematic Review of the Literature, Respiration, doi:10.1159/000321231
Mahler, Horowitz, Perception of Breathlessness During Exercise in Patients with Respiratory Disease, Med Sci Sports Exerc
Mentel, Shirrmakher, Kevich, Virus Inactivation by Hydrogen Peroxide, Vopr Virusol
Moghissi, Dixon, Gibbins, Does PDT Have Potential in the Treatment of COVID 19 Patients?, PhotodiagnosisPhotodynTher, doi:10.1016/j.pdpdt.2020.101889
Navid, Syed, Broad-spectrum Microbicidal Activity, Toxicologic Assessment, and Materials Compatibility of a New Generation of Accelerated Hydrogen Peroxide-Based Environmental Surface Disinfectant, Am J Infect Control, doi:10.1016/j.ajic.2005.06.002
Nianlinxie, Fengtian, Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury, BioMed Res Intl
Pedersen, Inhalers and Nebulizers: Which to Choose and Why, Resp Med, doi:10.1016/s0954-6111(96)90201-2
Pepose, Lee, Disinfection of Goldman Tonometers Against Human Immunodeficiency Virus Type 1, Journal of South Asian Federation of Obstetrics and Gynaecology, doi:10.1001/archopht.1989.01070020045026
Podoplekina, Shutova, Fyodorov, Influence of several chemical reagents on lymphocytic choriomeningitis and tacaribe viruses, Virologie
Rickloff, The Development of Vapor Phase Hydrogen Peroxide as a Sterilization Technology. Presentation at the Health Industry Manufacturers Association Conference
Schoeman, Fielding, Coronavirus envelope protein: current knowledge, Virol J
Sheldon, Brake, Hydrogen Peroxide as an Alternative Hatching Egg Disinfectant, Poultry Sci
Sporkenback, Meyer, Dernick, The Virus-Inactivating Effect of Inorganic Peroxy Compounds, Zentralbl Bakteriol Hyg B Ser Umwelthyg Krankenhaushyg Arbeitshyg Praev Med
Toledo, Escher, Ayres, Sporicidal Properties of Hydrogen Peroxide Against Food Spoilage Organisms, Appl Microbiol
Turner, Hydrogen peroxide and other oxidant disinfectants
Tyler, Ayliffe, Bradley, Virucidal Activity of Disinfectants: Studies with Poliovirus, J Hosp Infect, doi:10.1016/0195-6701(90)90090-b
Urban, Ratht, Radtke, Hydrogen Peroxide (H 2 O 2 ): A Review of Its Use in Surgery, Wien Med Wochenschr, doi:10.1007/s10354-017-0610-2
Van Haren, Page, Laffey, Nebulised Heparin as a Treatment for COVID-19: Scientific Rationale and a Call for Randomised Evidence, Crit Care, doi:10.1186/s13054-020-03148-2
Wardle, Renninger, Bacterial Effect of Hydrogen Peroxide on Spacecraft Iso-Lates, Appl Microbiol
Yoshpe-Purer, Eylan, Disinfection of Water by Hydrogen Peroxide, Health Lab Sci
Yuengsrigul, Chin, Nussbaum, Decreased Cytokine Production from Human Peripheral Blood Mononuclear Cells (pbmcs) by Furosemide. 77, Pediatr Res, doi:10.1203/00006450-199604001-00096
Zolotarskaia, Dukhovnaia, Rs Dreizin, Studies of the Possibilities of Inactivating Adeno-Associated Virus Type 4, Vopr Virusol
Late treatment
is less effective
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