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All Studies   Meta Analysis    Recent:   

Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients

Agrawal et al., Journal of South Asian Federation of Obstetrics and Gynaecology, doi:10.5005/jp-journals-10006-1986, HOPE in COVID-19, CTRI/2020/08/027038
Apr 2022  
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0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk Ventilation 67% Oxygen time 46% Recovery time, dyspnea 36% Recovery time, fever 39% Recovery time, cough 30% Time to viral- 45% Hydrogen Peroxide  HOPE in COVID-19  LATE TREATMENT  DB RCT Is late treatment with hydrogen peroxide beneficial for COVID-19? Double-blind RCT 40 patients in India Lower need for oxygen therapy (p<0.0001) and faster recovery (p<0.0001) c19early.org Agrawal et al., J. South Asian Federat.., Apr 2022 Favors hydrogen peroxide Favors control
19th treatment shown to reduce risk in May 2021
 
*, now known with p = 0.029 from 7 studies.
Lower risk for viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 40 patients in India, showing improved recovery with nebulized hydrogen peroxide.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of death, 66.7% lower, RR 0.33, p = 0.60, treatment 1 of 20 (5.0%), control 3 of 20 (15.0%), NNT 10.0.
risk of mechanical ventilation, 66.7% lower, RR 0.33, p = 0.60, treatment 1 of 20 (5.0%), control 3 of 20 (15.0%), NNT 10.0.
oxygen time, 46.3% lower, relative time 0.54, p < 0.001, treatment mean 4.74 (±1.62) n=19, control mean 8.82 (±1.59) n=17.
recovery time, 35.7% lower, relative time 0.64, p < 0.001, treatment mean 4.58 (±1.12) n=19, control mean 7.12 (±1.05) n=17, dyspnea.
recovery time, 38.9% lower, relative time 0.61, p < 0.001, treatment mean 2.84 (±1.01) n=19, control mean 4.65 (±1.22) n=17, fever.
recovery time, 29.8% lower, relative time 0.70, p = 0.001, treatment mean 4.79 (±1.84) n=19, control mean 6.82 (±1.51) n=17, cough.
time to viral-, 45.2% lower, relative time 0.55, p < 0.001, treatment mean 5.16 (±1.21) n=19, control mean 9.41 (±1.97) n=17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Agrawal et al., 5 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, mean age 47.0, 8 authors, trial CTRI/2020/08/027038 (HOPE in COVID-19). Contact: dr.akhilpratapsingh1@gmail.com.
This PaperHydrogen Per..All
Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients
Arti Agrawal, Prabhat Agrawal, Ashish Gautam, Nikhil Pursnani, Prashant Gupta, Akhil Pratap Singh, Ruchika Garg, Ajeet Singh Chahar
Journal of South Asian Federation of Obstetrics and Gynaecology, doi:10.5005/jp-journals-10006-1986
Importance: Given the high mortality and cost of health care, especially in isolation settings, the idea of using nebulized hydrogen peroxide may play a very significant role in inactivation of coronavirus, thus reducing the infectivity period leading to reduced requirement of isolation and improving morbidity and mortality in people suffering with coronavirus disease-2019 (COVID-2019). Aim and objective: Objective of this study was to determine the efficiency of nebulized hydrogen peroxide (H 2 O 2 ) in reducing the viral load and disease severity of patients suffering with COVID-19. Design: Double-blinded randomized control trial. HOPE in COVID-19 study. Setting: Tertiary care COVID hospital (single center). Participants: Moderate sick COVID-19-positive patients were included in the study after they qualified the inclusion criteria. Intervention: Patients were nebulized using 1 mL of ozonized H 2 O 2 after diluting with 4 mL of normal saline three times a day for 5 days. The control group was nebulized with normal saline only. Main outcome: Outcome was assessed for reduction in oxygen requirement (number of days on oxygen), symptoms resolution (dyspnea, cough, and fever), and number of days it took to be RT-PCR negative for COVID-19. Results: The early data from trial showed promising trends toward a better outcome. The study showed that in the case group who were nebulized with hydrogen peroxide resulted in better outcome in terms of parameters assessed in the study and the differences from the control group were statistically significant (p ≤0.001, CI 95%). Outcome in the form of mortality (odds ratio 0.29, 95% CI 0.02-3.14, p = 0.31, z = 1.007) was statistically insignificant. The number needed to treat for our study was 10.
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DOI: ' '10.1016/j.jinf.2020.05.046.', 'DOI': '10.1016/j.jinf.2020.05.046'}], 'container-title': 'Journal of South Asian Federation of Obstetrics and Gynaecology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.jsafog.com/doi/pdf/10.5005/jp-journals-10006-1986', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 15]], 'date-time': '2022-07-15T14:50:28Z', 'timestamp': 1657896628000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.jsafog.com/doi/10.5005/jp-journals-10006-1986'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 4, 5]]}, 'references-count': 38, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2022]]}}, 'alternative-id': ['10.5005/jp-journals-10006-1986'], 'URL': 'http://dx.doi.org/10.5005/jp-journals-10006-1986', 'relation': {}, 'ISSN': ['0974-8938', '0975-1920'], 'subject': ['Obstetrics and Gynecology'], 'published': {'date-parts': [[2022, 4, 5]]}}
Late treatment
is less effective
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