Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients

{ 'indexed': {'date-parts': [[2022, 7, 15]], 'date-time': '2022-07-15T15:15:20Z', 'timestamp': 1657898120855}, 'reference-count': 38, 'publisher': 'Jaypee Brothers Medical Publishing', 'issue': '1', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 4, 5]]}, 'DOI': '10.5005/jp-journals-10006-1986', 'type': 'journal-article', 'created': {'date-parts': [[2022, 4, 5]], 'date-time': '2022-04-05T10:08:46Z', 'timestamp': 1649153326000}, 'page': '35-40', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of ' 'Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus ' 'Infectivity and Clinical Course among Moderately Sick COVID-19 Patients', 'prefix': '10.5005', 'volume': '14', 'author': [ {'given': 'Arti', 'family': 'Agrawal', 'sequence': 'first', 'affiliation': []}, {'given': 'Prabhat', 'family': 'Agrawal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ashish', 'family': 'Gautam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nikhil', 'family': 'Pursnani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Prashant', 'family': 'Gupta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Akhil Pratap', 'family': 'Singh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruchika', 'family': 'Garg', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ajeet Singh', 'family': 'Chahar', 'sequence': 'additional', 'affiliation': []}], 'member': '2914', 'published-online': {'date-parts': [[2022, 4, 5]]}, 'reference': [ { 'key': 'ref=1', 'unstructured': '1. Coronavirus disease (COVID-19) Situation Report, by WHO published on ' 'August 30, 2020.'}, { 'key': 'ref=2', 'unstructured': '2. Available from: https://www.mygov.in/covid-19/, accessed on 30 ' 'August.'}, { 'key': 'ref=3', 'doi-asserted-by': 'crossref', 'unstructured': '3. Huang L, Zhang X, Zhang X, et al. Rapid Asymptomatic Transmission of ' 'COVID-19 During the Incubation Period Demonstrating Strong Infectivity ' 'in a Cluster of Youngsters Aged 16–23 Years Outside Wuhan and ' 'Characteristics of Young Patients with COVID-19: A Prospective ' 'Contact-Tracing Study. J Infect 2020;80(6):e1–e13. DOI: ' '10.1016/j.jinf.2020.03.006.', 'DOI': '10.1016/j.jinf.2020.03.006'}, { 'key': 'ref=4', 'doi-asserted-by': 'crossref', 'unstructured': '4. Schoeman D, Fielding BC. Coronavirus envelope protein: current ' 'knowledge. Virol J 16, 69 (2019). Available from: ' 'https://doi.org/10.1186/s12985-019-1182-0.', 'DOI': '10.1186/s12985-019-1182-0'}, { 'key': 'ref=5', 'unstructured': '5. Foulon F. 2019. Preparing for ASFv: an ‘enveloped virus’. Pig ' 'Progress, oct 2.'}, { 'key': 'ref=6', 'unstructured': '6. Zolotarskaia EE, EM Dukhovnaia, RS Dreizin. Studies of the ' 'Possibilities of Inactivating Adeno-Associated Virus Type 4. Vopr ' 'Virusol 1975; 341–344. Volume 3. PMID: 1162954.'}, { 'key': 'ref=7', 'unstructured': '7. Mentel R, Shirrmakher R, Kevich A, et al. Virus Inactivation by ' 'Hydrogen Peroxide. Vopr Virusol 1977;731–733. Volume 6. PMID: 203115.'}, { 'key': 'ref=8', 'unstructured': '8. Podoplekina LE, Shutova NA, Fyodorov YV. Influence of several ' 'chemical reagents on lymphocytic choriomeningitis and tacaribe viruses. ' 'Virologie 37:43–48. PMID: 3962180.'}, { 'key': 'ref=9', 'unstructured': '9. Sporkenback HJ, Meyer PK, Dernick R. The Virus-Inactivating Effect of ' 'Inorganic Peroxy Compounds. Zentralbl Bakteriol Hyg B Ser Umwelthyg ' 'Krankenhaushyg Arbeitshyg Praev Med 1987;184:253–261.'}, { 'key': 'ref=10', 'doi-asserted-by': 'crossref', 'unstructured': '10. Pepose JS, Linette G, Lee SF, et al. Disinfection of Goldman ' 'Tonometers Against Human Immunodeficiency Virus Type 1. Arch Ophthalmol ' '1989;107:983–985. DOI: 10.1001/archopht.1989.01070020045026.', 'DOI': '10.1001/archopht.1989.01070020045026'}, { 'key': 'ref=11', 'doi-asserted-by': 'crossref', 'unstructured': '11. Tyler R, Ayliffe GA, Bradley C. Virucidal Activity of Disinfectants: ' 'Studies with Poliovirus. J Hosp Infect 1990;15:339–345. DOI: ' '10.1016/0195-6701(90)90090-b.', 'DOI': '10.1016/0195-6701(90)90090-B'}, { 'key': 'ref=12', 'unstructured': '12. Fox PF, Kosikowski FV. Heat-treated and Hydrogen Peroxide Treated ' 'Milks for Ched-dar Cheese. J Dairy Sci 1962;45:648.'}, { 'key': 'ref=13', 'unstructured': '13. Yoshpe-Purer Y, Eylan E. Disinfection of Water by Hydrogen Peroxide. ' 'Health Lab Sci 1968;5:233–238. PMID: 4880129.'}, { 'key': 'ref=14', 'doi-asserted-by': 'crossref', 'unstructured': '14. Toledo RT, Escher FE, Ayres JC. Sporicidal Properties of Hydrogen ' 'Peroxide Against Food Spoilage Organisms. Appl Microbiol ' '1973;26:592–597. PMID: 16349974.', 'DOI': '10.1128/am.26.4.592-597.1973'}, { 'key': 'ref=15', 'doi-asserted-by': 'crossref', 'unstructured': '15. Wardle MD, Renninger GM. Bacterial Effect of Hydrogen Peroxide on ' 'Spacecraft Iso-Lates. Appl Microbiol 1975;30:710–711. PMID: 1190768.', 'DOI': '10.1128/am.30.4.710-711.1975'}, { 'key': 'ref=16', 'unstructured': '16. Favero MS. Chemical Disinfection of Medical and Surgical Materials. ' 'In: Disin- fection, Sterilization, and Preservation. 3rd ed. S. S. ' 'Block, ed. Lea and Febiger, Philadelphia, PA.'}, { 'key': 'ref=17', 'unstructured': '17. Turner FJ. 1983. Hydrogen peroxide and other oxidant disinfectants. ' 'Pages 240–249 in: Disin- fection, Sterilization, and Preservation. 3rd ' 'ed., 469–492, S. S. Block, ed. Lea and Febiger, Philadelphia, PA.'}, { 'key': 'ref=18', 'doi-asserted-by': 'crossref', 'unstructured': '18. Sheldon BW, Brake J. Hydrogen Peroxide as an Alternative Hatching ' 'Egg Disinfectant. Poultry Sci 1991;70:1092–1098.', 'DOI': '10.3382/ps.0701092'}, { 'key': 'ref=19', 'unstructured': '19. Rickloff JR, 1988. The Development of Vapor Phase Hydrogen Peroxide ' 'as a Sterilization Technology. Presentation at the Health Industry ' 'Manufacturers Association Conference. October 30–November 1, Washington, ' 'DC.'}, { 'key': 'ref=20', 'doi-asserted-by': 'crossref', 'unstructured': '20. Klapes AN, Vesley D. Vapor-phase Hydrogen Peroxide as a Surface ' 'Decontaminant and Sterilant. Appl Environ Microbiol 1990;56:503–506. ' 'PMID: 2106287.', 'DOI': '10.1128/aem.56.2.503-506.1990'}, { 'key': 'ref=21', 'doi-asserted-by': 'crossref', 'unstructured': '21. Amanna IJ, Raué HP, Slifka MK. Development of a New Hydrogen ' 'Peroxide–Based Vaccine Platform. Nat Med 2012;18(6):974–979. DOI: ' '10.1038/nm.2763.', 'DOI': '10.1038/nm.2763'}, { 'key': 'ref=22', 'doi-asserted-by': 'crossref', 'unstructured': '22. Omidbakhsh Navid, Sattar Syed. Broad-spectrum Microbicidal Activity, ' 'Toxicologic Assessment, and Materials Compatibility of a New Generation ' 'of Accelerated Hydrogen Peroxide-Based Environmental Surface ' 'Disinfectant. Am J Infect Control 2006;34: 251–257. DOI: ' '10.1016/j.ajic.2005.06.002.', 'DOI': '10.1016/j.ajic.2005.06.002'}, { 'key': 'ref=23', 'doi-asserted-by': 'crossref', 'unstructured': '23. Kampf G, Todt D, Pfaender S, et al. Persistence of Coronaviruses on ' 'Inanimate Surfaces and Their Inactivation with Biocidal Agents ' '[published correction appears in J Hosp Infect 2020 Jun 17]. J Hosp ' 'Infect 2020;104(3):246–251. DOI: 10.1016/j.jhin.2020.01.022.', 'DOI': '10.1016/j.jhin.2020.01.022'}, {'key': 'ref=24', 'unstructured': '24. Blockaid-Disinfection-Information-Sheet-2020-v3.'}, { 'key': 'ref=25', 'doi-asserted-by': 'crossref', 'unstructured': '25. Urban MV, Rath T, Radtke C. Hydrogen Peroxide (Hsub2/subOsub2/sub): ' 'A Review of Its Use in Surgery. Wien Med Wochenschr 2019;169:222–225. ' 'DOI: 10.1007/s10354-017-0610-2.', 'DOI': '10.1007/s10354-017-0610-2'}, { 'key': 'ref=26', 'doi-asserted-by': 'crossref', 'unstructured': '26. Caruso AA, Del Prete A, Lazzarino AI, et al. Might Hydrogen Peroxide ' 'Reduce the Hospitalization Rate and Complications of SARS-CoV-2 ' 'Infection? [published online ahead of print, 2020 Apr 22]. Infect ' 'Control HospEpidemiol 2020;1–2. DOI: 10.1017/ice.2020.170.', 'DOI': '10.1017/ice.2020.170'}, { 'key': 'ref=27', 'doi-asserted-by': 'crossref', 'unstructured': '27. Mahler DA, Horowitz MB. Perception of Breathlessness During Exercise ' 'in Patients with Respiratory Disease. Med Sci Sports Exerc ' '1994;26:1078–1081. PMID: 7808239.', 'DOI': '10.1249/00005768-199409000-00002'}, { 'key': 'ref=28', 'doi-asserted-by': 'crossref', 'unstructured': '28. Leconte S, Ferrant D, Dory V, et al. Validated Methods of Cough ' 'Assessment: A Systematic Review of the Literature. Respiration 2011;81: ' '161–174. DOI: 10.1159/000321231.', 'DOI': '10.1159/000321231'}, { 'key': 'ref=29', 'doi-asserted-by': 'crossref', 'unstructured': '29. Pedersen S. Inhalers and Nebulizers: Which to Choose and Why. Resp ' 'Med 1996;2:69–77. DOI: 10.1016/s0954-6111(96)90201-2.', 'DOI': '10.1016/S0954-6111(96)90201-2'}, { 'key': 'ref=30', 'doi-asserted-by': 'crossref', 'unstructured': '30. NianlinXie, MengleiHuan, FengTian, et al. Low Molecular Weight ' 'Heparin Nebulization Attenuates Acute Lung Injury. BioMed Res Intl ' '2017;5. Article ID: 3169179.', 'DOI': '10.1155/2017/3169179'}, { 'key': 'ref=31', 'doi-asserted-by': 'crossref', 'unstructured': '31. Carr J. The Anti-inflammatory Action of Heparin: Heparin as an ' 'Antagonist Tohistamine, Bradykinin and Prostaglandin E1. Thromb Res ' '1979;16(3–4):507–516. DOI: 10.1016/0049-3848(79)90097-5.', 'DOI': '10.1016/0049-3848(79)90097-5'}, { 'key': 'ref=32', 'doi-asserted-by': 'crossref', 'unstructured': '32. Koenig A, Norgard-Sumnicht K, Linhardt R, et al. Differential ' 'Interactions of Heparin and Heparan Sulfate Glycosaminoglycans with the ' 'Selectins. Implications for the Use of Unfractionated and Low Molecular ' 'Weightheparins as Therapeutic Agents. J Clin Invest 1998;101(4):877–889. ' 'PMID: 9466983.', 'DOI': '10.1172/JCI1509'}, { 'key': 'ref=33', 'doi-asserted-by': 'crossref', 'unstructured': '33. Van Haren FMP, Page C, Laffey JG et al. Nebulised Heparin as a ' 'Treatment for COVID-19: Scientific Rationale and a Call for Randomised ' 'Evidence. Crit Care 2020;24:454. DOI: 10.1186/s13054-020-03148-2.', 'DOI': '10.1186/s13054-020-03148-2'}, { 'key': 'ref=34', 'doi-asserted-by': 'crossref', 'unstructured': '34. Yuengsrigul A, Chin T, Nussbaum E. Decreased Cytokine Production ' 'from Human Peripheral Blood Mononuclear Cells (pbmcs) by Furosemide. 77. ' 'Pediatr Res 1996;39:15. Available from: ' 'https://doi.org/10.1203/00006450-199604001-00096.', 'DOI': '10.1203/00006450-199604001-00096'}, { 'key': 'ref=35', 'doi-asserted-by': 'crossref', 'unstructured': '35. Brennecke A, Villar L, Wang Z, et al. Is Inhaled Furosemide a ' 'Potential Therapeutic for COVID-19? Am J Med Sci 2020;360(3):216–221. ' 'DOI: 10.1016/j.amjms.2020.05.044.', 'DOI': '10.1016/j.amjms.2020.05.044'}, { 'key': 'ref=36', 'doi-asserted-by': 'crossref', 'unstructured': '36. Moghissi K, Dixon K, Gibbins S. Does PDT Have Potential in the ' 'Treatment of COVID 19 Patients? [published online ahead of print, 2020 ' 'Jun 24]. Photodiagnosis Photodyn Ther 2020;31:101889. DOI: ' '10.1016/j.pdpdt.2020.101889.', 'DOI': '10.1016/j.pdpdt.2020.101889'}, { 'key': 'ref=37', 'doi-asserted-by': 'crossref', 'unstructured': '37. Alamdari DH, Moghaddam AB, Amini S, et al. Application of Methylene ' 'Blue-Vitamin C -N-Acetyl Cysteine for Treatment of Critically Ill ' 'COVID-19 Patients, Report of a Phase-I Clinical Trial [published online ' 'ahead of print, 2020 Aug 20]. Eur J Pharmacol 2020;885:173494. DOI: ' '10.1016/j.ejphar.2020.173494.', 'DOI': '10.1016/j.ejphar.2020.173494'}, { 'key': 'ref=38', 'doi-asserted-by': 'crossref', 'unstructured': '38. Lansbury L, Lim B, Baskaran V, et al. Co-infections in People with ' 'COVID-19: A Systematic Review and Meta-analysis [published online ahead ' 'of print, 2020 May 27]. J Infect 2020;S0163–4453(20)30323–30326. DOI: ' '10.1016/j.jinf.2020.05.046.', 'DOI': '10.1016/j.jinf.2020.05.046'}], 'container-title': 'Journal of South Asian Federation of Obstetrics and Gynaecology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.jsafog.com/doi/pdf/10.5005/jp-journals-10006-1986', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 15]], 'date-time': '2022-07-15T14:50:28Z', 'timestamp': 1657896628000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.jsafog.com/doi/10.5005/jp-journals-10006-1986'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 4, 5]]}, 'references-count': 38, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2022]]}}, 'alternative-id': ['10.5005/jp-journals-10006-1986'], 'URL': 'http://dx.doi.org/10.5005/jp-journals-10006-1986', 'relation': {}, 'ISSN': ['0974-8938', '0975-1920'], 'subject': ['Obstetrics and Gynecology'], 'published': {'date-parts': [[2022, 4, 5]]}}