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0 0.5 1 1.5 2+ Mortality -56% Improvement Relative Risk Acetaminophen  Abolhassani et al.  LATE TREATMENT Is late treatment with acetaminophen beneficial for COVID-19? Retrospective 31 patients in Iran Study underpowered to detect differences c19early.org Abolhassani et al., J. Allergy and Cli.., Sep 2022 Favors acetaminophen Favors control

Genetic and immunological evaluation of children with inborn errors of immunity and severe or critical COVID-19

Abolhassani et al., Journal of Allergy and Clinical Immunology, doi:10.1016/j.jaci.2022.09.005
Sep 2022  
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1st treatment shown to increase risk in November 2020
 
*, now known with p = 0.00000029 from 28 studies, but still recommended in 46 countries.
* From meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 31 hospitalized patients ≤19 with pre-existing inborn errors of immunity, showing no significant difference in mortality with acetaminophen. Only 6 patients were treated with acetaminophen.
Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
risk of death, 56.2% higher, RR 1.56, p = 0.64, treatment 3 of 6 (50.0%), control 8 of 25 (32.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abolhassani et al., 13 Sep 2022, retrospective, Iran, peer-reviewed, 23 authors. Contact: qiang.pan-hammarstrom@ki.se (corresponding author), lennart.hammarstrom@ki.se.
This PaperAcetaminophenAll
Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19
MD, PhD Hassan Abolhassani, PhD Samaneh Delavari, MD, PhD Nils Landegren, PhD Sima Shokri, MD, PhD Paul Bastard, PhD Likun Du, PhD Fanglei Zuo, PhD Reza Hajebi, MD Farhad Abolnezhadian, MD Sara Iranparast, MD Mohammadreza Modaresi, MD Ahmad Vosughimotlagh, MSc Fereshte Salami, PhD Maribel Aranda-Guillén, MD, PhD Aurélie Cobat, PhD Harold Marcotte, MD, PhD Shen-Ying Zhang, PhD Qian Zhang, MD, PhD Nima Rezaei, MD, PhD Jean-Laurent Casanova, MD, PhD Olle Kämpe, MD, PhD Lennart Hammarström, MD, PhD Qiang Pan-Hammarström
Journal of Allergy and Clinical Immunology, doi:10.1016/j.jaci.2022.09.005
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Abbreviations J o u r n a l P r e -p r o o f Author contributions HA, SD, NL, SS, PB, LD, FZ, AH, FA, SI, MM, AV, FS, MAG, were involved in subject recruitment and sample acquisition. HA, NL, AC, HM, SYZ, QZ, NR, JLC, OK, LH, QPH were involved in the interpretation of results HA, LH, QPH wrote the manuscript. All authors reviewed and approved the manuscript. LH, and QPH designed the laboratory protocols and supervised the entirety of the project. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Late treatment
is less effective
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