Associations between the Dietary Inflammatory Index and COVID-19 Outcomes in the UK Biobank Cohort
Zhao et al.,
Associations between the Dietary Inflammatory Index and COVID-19 Outcomes in the UK Biobank Cohort,
SSRN Electronic Journal, doi:10.2139/ssrn.4300209
UK Biobank retrospective 196,154 participants with 11,288 COVID-19 cases, showing lower COVID-19 mortality, severity, and incidence for lower dietary inflammatory scores.
risk of death, 24.2% lower, RR 0.76, p = 0.13, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, E-DII, quintile 1 vs. quintile 5, multivariable, model 4.
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risk of death, 30.1% lower, RR 0.70, p = 0.04, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, DII, quintile 1 vs. quintile 5, multivariable, model 4.
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risk of severe case, 28.1% lower, RR 0.72, p < 0.001, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, E-DII, quintile 1 vs. quintile 5, multivariable, model 4.
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risk of severe case, 28.6% lower, RR 0.71, p < 0.001, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, DII, quintile 1 vs. quintile 5, multivariable, model 4.
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risk of case, 14.5% lower, RR 0.85, p < 0.001, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, E-DII, quintile 1 vs. quintile 5, multivariable, model 4.
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risk of case, 9.1% lower, RR 0.91, p = 0.002, higher quality diet 39,230, lower quality diet 39,231, adjusted per study, inverted to make RR<1 favor higher quality diet, DII, quintile 1 vs. quintile 5, multivariable, model 4.
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Zhao et al., 14 Dec 2022, retrospective, United Kingdom, peer-reviewed, survey, 9 authors, study period January 2020 - March 2021.
Contact:
jhebert@mailbox.sc.edu.
Abstract: UK Biobank Cohort
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Associations between the Dietary Inflammatory Index and COVID-19 outcomes in the
Author: Longgang Zhao, MSc1,2 Michael D. Wirth, PhD1,2,3,4 Fanny Petermann-Rocha, PhD
5,6 Solange Parra-Soto, PhD 5,7 John C. Mathers, PhD 8 Jill P. Pell, PhD 9 Frederick K. Ho,
Authors’ Affiliations
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PhD 9 Carlos A. Celis-Morales, PhD5,10 James R. Hébert, ScD1,2,4
1. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University
of South Carolina, Columbia, SC, 29208, USA.
2. Cancer Prevention and Control Program and Department of Epidemiology and
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Biostatistics, University of South Carolina, Columbia, SC, 29208, USA.
3. College of Nursing, University of South Carolina, Columbia, SC, 29208, USA.
4. Department of Nutrition, Connecting Health Innovations LLC, Columbia, SC, 29201,
USA.
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5. School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12
8TA, UK.
6. Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales,
Santiago, 8370068, Chile.
Chile.
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7. Department of Nutrition and Public Health, Universidad del Bío-Bío, Chillan, 3780000,
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8. Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population
Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
9. School of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK.
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10. Human Performance Lab, Education, Physical Activity and Health Research Unit,
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University Católica del Maule, Talca, 3466706, Chile.
Correspondence:
James R. Hébert
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This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=4300209
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Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics,
University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
E-mail: JHEBERT@mailbox.sc.edu.
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Title page
Running title: DII and COVID-19
Total page length: 25 pages
Word count:
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Text (Excluding Abstract, References, Tables, and Figures) = 2982 words; Abstract = 292
words; References = 54
Tables and Figures:
Tables: 3; Figures: 0
Supplemental tables: 1
Supplemental figures: 4
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Additional Files:
Abbreviations used in this paper:
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DII, dietary inflammatory index
E-DII, energy-adjusted DII
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NHS, National Health Service
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2/24
This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=4300209
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Research in context
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Evidence before this study
We conducted a systematic search of the National Library of Medicine for articles on
associations between diet and COVID-19 risk. We found that a limited number of studies
have evaluated the role of specific food groups in the onset and progression of SARS-CoV-2
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infection and COVID-19 symptoms. However, evidence on associations..
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