Analysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19
Xiao-Yu Zhang, Tao Li, Haibing Wu, Yun Ling, Zhi-Ping Qian, Liang Chen
Journal of Inflammation Research, doi:10.2147/jir.s292303
Objective: This study is to evaluate the effect of proton-pump inhibitors on the course of COVID-19. Methods: Clinical data of moderate COVID-19 patients admitted to the Shanghai Public Health Clinical Center for treatment from January 20, 2020, to March 16, 2020, were collected. A retrospective study was conducted and the patients were divided into two groups according to whether they used proton-pump inhibitors or not. The differences in SARS-CoV -2 clearance and hospital stay between the two groups were compared by Cox proportional hazards (PH) regression models and the propensity score matching method. Results: A total of 154 patients with moderate COVID-19 were included in this study, including 80 males (51.9%), 35 patients (22.7%) in the proton-pump inhibitor group, and 119 patients (77.3%) in the control group. In the proton-pump inhibitor group and the control group, the duration of the SARS-CoV-2 clearance was 7 days (95% CI, 6-9) and 7 days (95% CI, 6-11), and the duration of the hospital stay was 21 days (95% CI, 16-25) and 20 days (95% CI, 15-26), respectively. There was no significant difference between the both groups in the cumulative incidence of the SARS-CoV-2 clearance and the discharge, and the same results were obtained after the propensity score matching, all P > 0.05. There was no significant association between the use of proton-pump inhibitors and the duration of SARS-CoV-2 clearance, according to univariate analysis (HR, 1.309; 95% CI, 0.893-1.918) and multivariate analysis (HR, 1.575; 95% CI, 0.993-2.499). There was no significant association between the use of proton-pump inhibitors and the duration of hospital stay for COVID-19, according to univariate analysis (HR, 1.044; 95% CI, 0.714-1.528) and multivariate analysis (HR, 1.064; 95% CI, 0.651-1.740).
Conclusion: The use of proton-pump inhibitors has no effect on prolonging or shortening the course of adults hospitalized with COVID-19.
Ethical Approval and Consent to Participate Informed consents of patients were obtained for diagnosis and treatment, and the study. Protocol was approved by the Shanghai Public Health Clinical Center Clinical Committee. All the data received Institutional Review Board (IRB) approval by the Ethics Committee. The IRB number was YJ-2020-S015-01.
Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Consent for publication: all authors have read and agreed to the published version of the manuscript. These authors contributed equally to this work and should be considered co-first authors: Xiao-Yu Zhang and Tao Li.
Disclosure The authors declare no conflicts of interest for this work.
Journal of Inflammation Research
Dovepress
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