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All Studies   Meta Analysis    Recent:   

Dynamic Model of Andrographolide Therapy for COVID-19

Yarnvitayalert et al., 2023 IEEE 5th Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability, doi:10.3390/engproc2023055081
Dec 2023  
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Pharmacokinetic and pharmacodynamic modeling of andrographolide for COVID-19. The model suggests that a dose of 60mg per day of andrographolide is optimal for reducing viral load and infection. The model incorporates the diffusion of the drug in plasma and tissues over time and its inhibitory impact on the viral life cycle.
Yarnvitayalert et al., 21 Dec 2023, Thailand, peer-reviewed, 2 authors. Contact: teerapol.sal@kmutt.ac.th (corresponding author), panittavee.n@mail.kmutt.ac.th.
This PaperAndrographisAll
Dynamic Model of Andrographolide Therapy for COVID-19
Panittavee Yarnvitayalert, Teerapol Saleewong
doi:10.3390/engproc2023055081
Andrographis paniculate extract (APE) has been used as a Thailand traditional medicine owing to andrographolide which is effective for the viral clearance and prevention of disease progression. Several viral infections have been treated with APE, including SARS-CoV-2. The recommended dosage is 180 mg three times a day. We constructed a mathematical viral dynamic model of the SARS-CoV-2 model with andrographolide therapy by different doses. The pharmacokinetic/pharmacodynamic (PK/PD) model reduces the duration of viral clearance with a dose of 60 mg per day. Moreover, APE improved the therapeutic efficacy of COVID-19 therapy.
Conflicts of Interest: The authors declare no conflict of interest.
References
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