Multi-Omics Blood Atlas Reveals Host Immune Response Features of Immunocompromised Populations Following SARS-CoV-2 Infection
Xiaodi Yang, Ye Shen, Bo Tang, Jialin Zhu, Bingjie Wang, Qingyun Wang, Wenmin Tian, Stefan Wuchty, Ziding Zhang, Zeyin Liang, Yujun Dong
Molecular & Cellular Proteomics, doi:10.1016/j.mcpro.2025.101068
This multi-omics study reveals distinct immune dysregulation in hematological tumor patients with COVID-19, showing severe proteomic network perturbations and divergent immune signatures between long COVID (immunosuppression) and fatal cases (hyperactivation). Network analysis identifies potential therapeutic targets (e.g., HSPA8, SRC, and STAT1) and drug candidates, offering insights into COVID-19 mechanisms and tailored treatment strategies for high-risk patients.
DATA AVAILABILITY Data supporting the findings of this study have been deposited in iProX (integrated proteome resources) Proteo-meXchange under accession code PXD063172. The data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. The data that support the findings of this study are available from the corresponding author upon reasonable request. Supplemental Data -This article contains supplemental data.
Ethics Approval and Consent to
Conflict of Interest - The authors declare that they do not have any conflicts of interest with the content of this article.
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