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All Studies   Meta Analysis    Recent:   

Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China

Yan et al., medRxiv, doi:10.1101/2020.03.19.20038539
Mar 2020  
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Severe case -240% Improvement Relative Risk PPIs for COVID-19  Yan et al.  Prophylaxis Is prophylaxis with PPIs beneficial for COVID-19? Retrospective 168 patients in China (January - March 2020) Higher severe cases with PPIs (p=0.000052) c19early.org Yan et al., medRxiv, March 2020 FavorsPPI Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020
 
*, now with p = 0.00000031 from 37 studies.
* From meta analysis with ≥3 studies.
4,700+ studies for 94 treatments. c19early.org
Retrospective 168 hospitalized COVID-19 patients in China showing higher risk of severe cases with acid suppression drugs.
risk of severe case, 240.0% higher, RR 3.40, p < 0.001, treatment 16 of 32 (50.0%), control 20 of 136 (14.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yan et al., 23 Mar 2020, retrospective, China, preprint, median age 51.0, 17 authors, study period 22 January, 2020 - 13 March, 2020. Contact: lvchuanzhu677@126.com.
This PaperPPIsAll
Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China
PhD Shijiao Yan, PhD Xingyue Song, MD Feng Lin, Haiyan Zhu, MD Xiaozhi Wang, MD Min Li, MD Jianwen Ruan, MD Changfeng Lin, MD Xiaoran Liu, PhD Qiang Wu, MS Zhiqian Luo, PhD Wenning Fu, MD Song Chen, MD Yong Yuan, MD Shengxing Liu, MD Jinjian Yao, MD Chuanzhu Lv
doi:10.1101/2020.03.19.20038539
Background: Since January 2020, coronavirus disease 2019 (Covid-19) has spread rapidly and developing the pandemic model around the world. Data have been needed on the clinical characteristics of the affected patients in an imported cases as model in island outside Wuhan. Methods: We conducted a retrospective study included all 168 confirmed cases of Covid-19 in Hainan province from 22 January 2020 to 13 March 2020. Cases were confirmed by real-time RT-PCR and were analysed for demographic, clinical, radiological and laboratory data. Results: Of 168 patients, 160 have been discharged, 6 have died and 2 remain hospitalized. The median age was 51.0 years and 51.8% were females. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 (30.4%) and 52 (31%) of patients lived in Wuhan or traveled to Wuhan, had contact with Covid-19 patients, or had contact with Wuhan residents, respectively. The most common symptoms at onset of illness were fever (65.5%), dry cough (48.8%) and expectoration (32.1%). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (60.2%). The elderly people with diabetes, hypertension and CVD are more likely to develop severe cases. Follow-up of 160 discharged patients found that 20 patients (12.5%) had a positive RT-PCR test results of pharyngeal swabs or anal swabs or fecal. Conclusions: In light of the rapid spread of Covid-19 around the world, early diagnosis and quarantine is important to curb the spread of Covid-19 and intensive
Course-Median (IQR), days Time from onset of symptoms to first hospital visit (N=168)
References
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Data have been needed on the clinical characteristics of the ' 'affected patients in an imported cases as model in island outside ' 'Wuhan.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a ' 'retrospective study included all 168 confirmed cases of Covid-19 in Hainan province from 22 ' 'January 2020 to 13 March 2020. Cases were confirmed by real-time RT-PCR and were analysed for ' 'demographic, clinical, radiological and laboratory ' 'data.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 168 patients, ' '160 have been discharged, 6 have died and 2 remain hospitalized. The median age was 51.0 ' 'years and 51.8% were females. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 ' '(30.4%) and 52 (31%) of patients lived in Wuhan or traveled to Wuhan, had contact with ' 'Covid-19 patients, or had contact with Wuhan residents, respectively. 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