Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchProton Pump InhibitorsPPIs (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China

Yan et al., medRxiv, doi:10.1101/2020.03.19.20038539
Mar 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Severe case -240% Improvement Relative Risk Proton Pump Inhibitors  Yan et al.  Prophylaxis Is prophylaxis with proton pump inhibitors beneficial for COVID-19? Retrospective 168 patients in China (January - March 2020) Higher severe cases with proton pump inhibitors (p=0.000052) c19early.org Yan et al., medRxiv, March 2020 FavorsPPIs Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 112 treatments. c19early.org
Retrospective 168 hospitalized COVID-19 patients in China showing higher risk of severe cases with acid suppression drugs.
risk of severe case, 240.0% higher, RR 3.40, p < 0.001, treatment 16 of 32 (50.0%), control 20 of 136 (14.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yan et al., 23 Mar 2020, retrospective, China, preprint, median age 51.0, 17 authors, study period 22 January, 2020 - 13 March, 2020. Contact: lvchuanzhu677@126.com.
This PaperPPIsAll
Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China
PhD Shijiao Yan, PhD Xingyue Song, MD Feng Lin, Haiyan Zhu, MD Xiaozhi Wang, MD Min Li, MD Jianwen Ruan, MD Changfeng Lin, MD Xiaoran Liu, PhD Qiang Wu, MS Zhiqian Luo, PhD Wenning Fu, MD Song Chen, MD Yong Yuan, MD Shengxing Liu, MD Jinjian Yao, MD Chuanzhu Lv
doi:10.1101/2020.03.19.20038539
Background: Since January 2020, coronavirus disease 2019 (Covid-19) has spread rapidly and developing the pandemic model around the world. Data have been needed on the clinical characteristics of the affected patients in an imported cases as model in island outside Wuhan. Methods: We conducted a retrospective study included all 168 confirmed cases of Covid-19 in Hainan province from 22 January 2020 to 13 March 2020. Cases were confirmed by real-time RT-PCR and were analysed for demographic, clinical, radiological and laboratory data. Results: Of 168 patients, 160 have been discharged, 6 have died and 2 remain hospitalized. The median age was 51.0 years and 51.8% were females. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 (30.4%) and 52 (31%) of patients lived in Wuhan or traveled to Wuhan, had contact with Covid-19 patients, or had contact with Wuhan residents, respectively. The most common symptoms at onset of illness were fever (65.5%), dry cough (48.8%) and expectoration (32.1%). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (60.2%). The elderly people with diabetes, hypertension and CVD are more likely to develop severe cases. Follow-up of 160 discharged patients found that 20 patients (12.5%) had a positive RT-PCR test results of pharyngeal swabs or anal swabs or fecal. Conclusions: In light of the rapid spread of Covid-19 around the world, early diagnosis and quarantine is important to curb the spread of Covid-19 and intensive
Course-Median (IQR), days Time from onset of symptoms to first hospital visit (N=168)
References
Chan, Kok, Zhu, Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan, Emerg Microbes Infect
Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet
Force, Ranieri, Rubenfeld, Acute respiratory distress syndrome: the Berlin Definition, JAMA
Gao, Wang, Gu, Association Between Cardiac Injury and Mortality in Hospitalized Patients Infected With Avian Influenza A (H7N9) Virus, Crit Care
Guan, Ni, Hu, Clinical Characteristics of Coronavirus Disease 2019 in China, N Engl J Med
Holshue, Debolt, Lindquist, First Case of 2019 Novel Coronavirus in the United States, N Engl J Med
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Khwaja, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clinical practice
Li, Guan, Wu, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia, N Engl J Med
Lin, Fong, Zhu, Karlberg, Environmental factors on the SARS epidemic: air temperature, passage of time and multiplicative effect of hospital infection, Epidemiol Infect
Lu, Stratton, Tang, Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle, J Med Virol
Phan, Nguyen, Luong, Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam, N Engl J Med
Rothe, Schunk, Sothmann, Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, N Engl J Med
Singer, Granger, Inflammatory responses underlying the microvascular dysfunction associated with obesity and insulin resistance, Microcirculation
Van Den Oever, Raterman, Nurmohamed, Simsek, Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus, Mediators Inflamm
Wang, Hu, Hu, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China, JAMA
Xu, Li, Zhu, Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding, Nature Medicine
Xu, Wu, Jiang, Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series, BMJ
Yang, Cao, Qin, Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China, J Infect
Yang, Yu, Xu, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, The Lancet Respiratory Medicine
Zhang, Dong, Cao, Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China, Allergy
Zhou, Yang, Wang, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature
Zhu, Zhang, Wang, A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med
{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2024, 1, 29]], 'date-time': '2024-01-29T18:05:59Z', 'timestamp': 1706551559330}, 'posted': {'date-parts': [[2020, 3, 23]]}, 'group-title': 'Infectious Diseases (except HIV/AIDS)', 'reference-count': 28, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 3, 23]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Since ' 'January 2020, coronavirus disease 2019 (Covid-19) has spread rapidly and developing the ' 'pandemic model around the world. Data have been needed on the clinical characteristics of the ' 'affected patients in an imported cases as model in island outside ' 'Wuhan.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a ' 'retrospective study included all 168 confirmed cases of Covid-19 in Hainan province from 22 ' 'January 2020 to 13 March 2020. Cases were confirmed by real-time RT-PCR and were analysed for ' 'demographic, clinical, radiological and laboratory ' 'data.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 168 patients, ' '160 have been discharged, 6 have died and 2 remain hospitalized. The median age was 51.0 ' 'years and 51.8% were females. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 ' '(30.4%) and 52 (31%) of patients lived in Wuhan or traveled to Wuhan, had contact with ' 'Covid-19 patients, or had contact with Wuhan residents, respectively. The most common ' 'symptoms at onset of illness were fever (65.5%), dry cough (48.8%) and expectoration (32.1%). ' 'On admission, ground-glass opacity was the most common radiologic finding on chest computed ' 'tomography (60.2%). The elderly people with diabetes, hypertension and CVD are more likely to ' 'develop severe cases. Follow-up of 160 discharged patients found that 20 patients (12.5%) had ' 'a positive RT-PCR test results of pharyngeal swabs or anal swabs or ' 'fecal.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In light of ' 'the rapid spread of Covid-19 around the world, early diagnosis and quarantine is important to ' 'curb the spread of Covid-19 and intensive treatments in early stage is to prevent patients ' 'away from critical condition.</jats:p></jats:sec>', 'DOI': '10.1101/2020.03.19.20038539', 'type': 'posted-content', 'created': {'date-parts': [[2020, 3, 23]], 'date-time': '2020-03-23T17:55:18Z', 'timestamp': 1584986118000}, 'source': 'Crossref', 'is-referenced-by-count': 20, 'title': 'Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China', 'prefix': '10.1101', 'author': [ {'given': 'Shijiao', 'family': 'Yan', 'sequence': 'first', 'affiliation': []}, {'given': 'Xingyue', 'family': 'Song', 'sequence': 'additional', 'affiliation': []}, {'given': 'Feng', 'family': 'Lin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Haiyan', 'family': 'Zhu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xiaozhi', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Min', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jianwen', 'family': 'Ruan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Changfeng', 'family': 'Lin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xiaoran', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Qiang', 'family': 'Wu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zhiqian', 'family': 'Luo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wenning', 'family': 'Fu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Song', 'family': 'Chen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yong', 'family': 'Yuan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shengxing', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jinjian', 'family': 'Yao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chuanzhu', 'family': 'Lv', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2020111711150685000_2020.03.19.20038539v1.1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.25678'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.2', 'doi-asserted-by': 'crossref', 'first-page': '221', 'DOI': '10.1080/22221751.2020.1719902', 'article-title': 'Genomic characterization of the 2019 novel human-pathogenic coronavirus ' 'isolated from a patient with atypical pneumonia after visiting Wuhan', 'volume': '9', 'year': '2020', 'journal-title': 'Emerg Microbes Infect'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.3', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2001017'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.4', 'unstructured': 'Zhou P , Yang XL , Wang XG , et al. A pneumonia outbreak associated with ' 'a new coronavirus of probable bat origin. Nature 2020.'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.5', 'first-page': '139', 'article-title': 'An update on the epidemiological characteristics of novel coronavirus ' 'pneumonia (COVID-19)', 'volume': '41', 'author': 'Special Expert Group for Control of the Epidemic of Novel Coronavirus ' 'Pneumonia of the Chinese Preventive Medicine Association', 'year': '2020', 'journal-title': 'Chinese Journal of Epidemiology'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.6', 'unstructured': 'Li Q , Guan X , Wu P , et al. Early Transmission Dynamics in Wuhan, ' 'China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med 2020.'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.7', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30183-5'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.8', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMc2001272'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.9', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMc2001468'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.10', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2001191'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.11', 'unstructured': 'World Health Organization. Coronavirus disease 2019 (COVID-19) Situation ' 'Report-53. March 13, 2020 ' '(https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200313-sitrep-53-Covid-19.pdf?sfvrsn=adb3f72_2).'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.12', 'doi-asserted-by': 'crossref', 'unstructured': 'Yang W , Cao Q , Qin L , et al. Clinical characteristics and imaging ' 'manifestations of the 2019 novel coronavirus disease (COVID-19):A ' 'multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020.', 'DOI': '10.1016/j.jinf.2020.02.016'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.13', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.m606'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.14', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30211-7'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.15', 'doi-asserted-by': 'crossref', 'unstructured': 'Wang D , Hu B , Hu C , et al. Clinical Characteristics of 138 ' 'Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in ' 'Wuhan, China. JAMA 2020.', 'DOI': '10.1001/jama.2020.1585'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.16', 'doi-asserted-by': 'crossref', 'first-page': '223', 'DOI': '10.1017/S0950268805005054', 'article-title': 'Environmental factors on the SARS epidemic: air temperature, passage of ' 'time and multiplicative effect of hospital infection', 'volume': '134', 'year': '2006', 'journal-title': 'Epidemiol Infect'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.17', 'unstructured': 'World Health Organization. Clinical management of severe acute ' 'respiratory infection when novel coronavirus (2019-nCoV) infection is ' 'suspected: interim guidance. March 5, 2020 ' '(https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf).'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.18', 'unstructured': 'National Health Commission of the People’s Republic of China. Diagnosis ' 'and treatment of new coronavirus pneumonia (trial version 3).March 13, ' '2020 ' '(http://www.nhc.gov.cn/xcs/zhengcwj/202001/f492c9153ea9437bb587ce2ffcbee1fa/files/39e7578d85964dbe81117736dd789d8f.pdf).'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.19', 'unstructured': 'National Health Commission of the People’s Republic of China. Diagnosis ' 'and treatment of new coronavirus pneumonia (trial version 7). March 13, ' '2020 ' '(http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf).'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.20', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2012.5669'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.21', 'doi-asserted-by': 'publisher', 'DOI': '10.1159/000339789'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.22', 'doi-asserted-by': 'crossref', 'unstructured': 'Gao C , Wang Y , Gu X , et al. Association Between Cardiac Injury and ' 'Mortality in Hospitalized Patients Infected With Avian Influenza A ' '(H7N9) Virus. Crit Care 2020.', 'DOI': '10.1097/CCM.0000000000004207'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.23', 'unstructured': 'Guan WJ , Ni ZY , Hu Y , et al. Clinical Characteristics of Coronavirus ' 'Disease 2019 in China. N Engl J Med 2020.'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.24', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2010/792393'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.25', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/10739680701283158'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.26', 'doi-asserted-by': 'crossref', 'unstructured': 'Xu Y , Li X , Zhu B , et al. Characteristics of pediatric SARS-CoV-2 ' 'infection and potential evidence for persistent fecal viral shedding. ' 'Nature Medicine 2020.', 'DOI': '10.1038/s41591-020-0817-4'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.27', 'doi-asserted-by': 'crossref', 'unstructured': 'Yang X , Yu Y , Xu J , et al. Clinical course and outcomes of critically ' 'ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a ' 'single-centered, retrospective, observational study. The Lancet ' 'Respiratory Medicine 2020.', 'DOI': '10.1016/S2213-2600(20)30079-5'}, { 'key': '2020111711150685000_2020.03.19.20038539v1.28', 'doi-asserted-by': 'crossref', 'unstructured': 'Zhang JJ , Dong X , Cao YY , et al. Clinical characteristics of 140 ' 'patients infected with SARS-CoV-2 in Wuhan, China. Allergy 2020.', 'DOI': '10.1111/all.14238'}], 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://syndication.highwire.org/content/doi/10.1101/2020.03.19.20038539', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2020, 11, 17]], 'date-time': '2020-11-17T19:15:34Z', 'timestamp': 1605640534000}, 'score': 1, 'resource': {'primary': {'URL': 'http://medrxiv.org/lookup/doi/10.1101/2020.03.19.20038539'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 3, 23]]}, 'references-count': 28, 'URL': 'http://dx.doi.org/10.1101/2020.03.19.20038539', 'relation': {}, 'subject': [], 'published': {'date-parts': [[2020, 3, 23]]}, 'subtype': 'preprint'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit