Aug 31 2023 |
et al., In Vivo, doi:10.21873/invivo.13313 | A Prospective Study of AFree Oral Spray as an Adjuvant Therapy for Mild and Moderate COVID-19 in Community Health Stations: Clinical Progression and Viral Clearance Outcomes |
| RCT 1,252 mild/moderate COVID-19 patients Vietnam, showing faster recovery and faster viral clearance with an oral spray containing zinc, propolis, xylitol, ginger, and DMSO. 5-10 times per day. | ||
Jun 27 2023 |
et al., In Vivo, doi:10.21873/invivo.13262 | Therapeutic Efficacy of AFree Oral Spray on the Symptoms and Course of Moderate and Severe COVID-19 in the Field Hospital |
| 84% improved recovery (p<0.0001) and 78% improved viral clearance (p=0.06). RCT 200 hospitalized patients in Vietnam, showing faster recovery with an oral spray containing zinc, propolis, xylitol, ginger, and DMSO. | ||
Nov 18 2022 |
et al., Pharmaceutics, doi:10.3390/pharmaceutics14112502 | Early Negativization of SARS-CoV-2 Infection by Nasal Spray of Seawater plus Additives: The RENAISSANCE Open-Label Controlled Clinical Trial |
| 32% improved viral clearance (p=0.05). 108 patient prospective study showing improved viral clearance with Panthexyl nasal spray (a sterile hypertonic solution containing seawater, xylitol, panthenol and lactic acid). | ||
Jul 25 2022 |
et al., Journal of Clinical Virology, doi:10.1016/j.jcv.2022.105248 | Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial. |
| 47% fewer symptomatic cases (p<0.0001) and 63% lower IgG positivity (p<0.0001). 648 patient RCT pHOXWELL nasal spray in India, showing significantly lower IgGS+ and significantly lower symptomatic cases with treatment. pHOXWELL includes a combination of natural virucidal agents and is designed to mimic the fluid surr.. | ||
Dec 21 2020 |
et al., bioRxiv, doi:10.1101/2020.12.02.408575 | In Vitro Analysis of the Anti-viral Potential of nasal spray constituents against SARS-CoV-2 |
| In Vitro study showing that a nasal spray with xylitol and grapefruit seed extract inhibited SARS-CoV-2. | ||
Nov 3 2020 |
et al., Cureus, doi:10.7759/cureus.11315 | Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution in COVID-19: Case Series |
| Case study of three patients suggesting faster clinical improvement and shorter time to viral clearance with a nasal spray containing xylitol and grapefruit seed extract. | ||
Aug 21 2020 |
et al., PLoS ONE, doi:10.1371/journal.pone.0259943 (date from preprint) | Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture |
| In Vitro study showing that iota-carrageenan in concentrations as low as 6 µg/mL (easily achievable with existing nasal sprays) inhibits SARS-CoV-2 in Vero cell cultures. Improved inhibition was seen when combined with xylitol, and inhibi.. | ||
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