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Effect of any form of steroids in comparison with that of other medications on the duration of olfactory dysfunction in patients with COVID-19: A systematic review of randomized trials and quasi-experimental studies

Winn et al., PLOS ONE, doi:10.1371/journal.pone.0288285
Aug 2023  
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Budesonide for COVID-19
19th treatment shown to reduce risk in April 2021
 
*, now with p = 0.0000011 from 15 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Review of the effects of various treatment options and interventions for COVID-19-related olfactory dysfunction. Authors analyzed 21 studies with a total of 130,550 patients to compare the efficacy of corticosteroid treatments with other medications and interventions. Nasal sprays containing mometasone furoate, fluticasone, triamcinolone acetonide, and betamethasone were the main corticosteroids evaluated. Other interventions included zinc supplements, carbamazepine, omega-3, palmitoylethanolamide plus luteolin, olfactory training, coffee, lavender syrup, and inflawell syrup. The corticosteroid nasal sprays fluticasone and triamcinolone acetonide showed the greatest reductions in smell loss duration compared to other treatments. Olfactory training alone was less effective than corticosteroids but authors recommend combination with other interventions.
Review covers zinc and budesonide.
Winn et al., 2 Aug 2023, peer-reviewed, 4 authors. Contact: mg.phyozinwinn@gmail.com.
This PaperBudesonideAll
Effect of any form of steroids in comparison with that of other medications on the duration of olfactory dysfunction in patients with COVID-19: A systematic review of randomized trials and quasi-experimental studies
Phyo Zin Winn, Thein Hlaing, Kyaw Myo Tun, Seim Lei Lei
PLOS ONE, doi:10.1371/journal.pone.0288285
Background The life quality of about two-thirds of patients with COVID-19 is affected by related olfactory dysfunctions. The negative impact of olfactory dysfunction ranged from the decreased pleasure of eating to impaired quality of life. This research aimed to provide a comprehensive understanding of the effects of corticosteroid treatments by comparing that to other currently available treatments and interventions. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist's 27-point checklist was used to conduct this review. PubMed (Public/Publisher MEDLINE), PubMed Central and EMBASE (Excerpta Medica Database) databases were conveniently selected and Boolean search commands were used for a comprehensive literature search. Five core search terms were "effects of treatments", " COVID-19-related olfactory dysfunction", "corticosteroids", "treatments" and "interventions". The reporting qualities of the included studies were appraised using JBI (Joanna Briggs Institute) appraisal tools. The characteristics of the 21 experimental studies with a total sample (of 130,550) were aggregated using frequencies and percentages and presented descriptively. The main interventions and their effects on the duration of the COVID-19-related olfactory dysfunction were narratively analyzed.
Dissemination plan The full dissertation paper will be submitted to the libraries of the University of Bedfordshire, UK and STIMU, Myanmar. A short report of this review will be posted to the public through popular social media: Facebook and Twitter. The key findings of this study will be distributed to the members of the medical profession in Myanmar through the annual medical conference organized and held by the Myanmar Medical Association (MMA). Finally, as an academic research paper, the major processes and key outputs of this systematic review will also be published in the PLOS One, a peer-reviewed open-access scientific journal. Administrative information The utilization of unauthorized intellectual properties is refrained by the authors. The whole paper is free from copying or stealing the ideas or artworks of other scholars, authors, and professional co-workers. This was the student dissertation work of Dr Phyo Zin Win which has been undertaken for the award of Master of Science in Public Health from the University of Bedfordshire (UK). The co-reviewer and supervisor had the responsibilities for designing the review, undertaking all processes of the systematic review and revising the manuscript together with the principal investigator. Another co-author had the responsibilities for selecting the studies per protocol, extracting the relevant data, and reviewing and editing the manuscript. Supporting information S1
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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