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0 0.5 1 1.5 2+ Severe case 72% Improvement Relative Risk Vitamin D for COVID-19  Wani et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 236 patients in India Lower severe cases with higher vitamin D levels (p=0.007) Wani et al., Intervirology, June 2023 Favors vitamin D Favors control

Impact of Age and Clinico-Biochemical Parameters on Clinical severity of SARS-CoV-2 Infection

Wani et al., Intervirology, doi:10.1159/000530906
Jun 2023  
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Retrospective 236 COVID-19 patients in India, showing higher risk of severe cases with vitamin D deficiency.
This is the 179th of 185 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 115 vigintillion). This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of severe case, 72.2% lower, OR 0.28, p = 0.007, high D levels (≥28ng/mL) 66, low D levels (<28ng/mL) 170, inverted to make OR<1 favor high D levels (≥28ng/mL), RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wani et al., 1 Jun 2023, retrospective, India, peer-reviewed, 5 authors.
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Impact of Age and Clinico-Biochemical Parameters on Clinical severity of SARS-CoV-2 Infection
Wani Sa, Shariq Ahmad Wani, Babar Gulzar, Dr Mosin Saleem Khan, Sabhiya Majid, Dr Irfan Ahmad Bhat
Introduction: The surge in novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to COrona VIrus Disease-2019 (COVID-19) has overwhelmed the health system. To help health-care workers and policy makers prioritize treatment and to decrease the burden on health systems caused by COVID-19, clinical severity along with various clinico-biochemical parameters was evaluated by designing a cross-sectional study comprising of 236 SARS-CoV-2 infected individuals from Kashmir valley, India. Methods: Briefly, Real time Polymerase chain reaction (RT-PCR) was used for the confirmation of SARS-CoV-2 infection. The principles of spectrophotometry and chemiluminescent micro particle immunoassay (CMIA) were employed to estimate the levels of Glucose, TSH and 25-hydroxy vitamin D levels in serum of infected patients. Results: A total of 236 patients infected with SARS-CoV-2 were taken for this cross-sectional study. Patients with COVID-19 had a male predominance (72.9% vs 27.1%) and higher prevalence of 25-hydroxy vitamin D deficiency (72.0% vs 28.0%) with a mean 25-hydroxy vitamin D levels of 24.0±13.9 in ng/ml. We observed a varied clinical spectrum of SARS-CoV-2 infection with 36.4%, 23.7% and 29.7% patients having mild, moderate and severe disease respectively. We observed that severity of SARS-CoV-2 infection was significantly associated with older age group, hypertension, low TSH levels and 25-hydroxy vitamin D deficiency. Discussion/Conclusion: We conclude that not only old age but hypertension and low levels of TSH and 25 Hydroxy Vitamin D Levels could significantly lead to clinical severity of SARS-CoV-2 infection.
Conflict of interest statement The authors declare that there is no conflict of interest Author Contribution Conceptualization: SAW, BG, MSK; Data curation: MSK; Formal analysis: SAW, BG, MSK; Funding acquisition: SM, IAB; Investigation: SAW, BG, MSK; Methodology: SAW, BG, MSK; Project administration: SM, IAB; Resources: SM; Software: MSK; Supervision: SM, IAB; Validation: MSK SM, IAB; Visualization: SAW, BG, MSK; Writing-original draft: MSK; Writing-review & editing: MSK, IAB; Approval of final manuscript: all authors.
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