Impact of Age and Clinico-Biochemical Parameters on Clinical severity of SARS-CoV-2 Infection
Wani Sa, Shariq Ahmad Wani, Babar Gulzar, Dr Mosin Saleem Khan, Sabhiya Majid, Dr Irfan Ahmad Bhat
doi:10.1159/000530906
Introduction: The surge in novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to COrona VIrus Disease-2019 (COVID-19) has overwhelmed the health system. To help health-care workers and policy makers prioritize treatment and to decrease the burden on health systems caused by COVID-19, clinical severity along with various clinico-biochemical parameters was evaluated by designing a cross-sectional study comprising of 236 SARS-CoV-2 infected individuals from Kashmir valley, India. Methods: Briefly, Real time Polymerase chain reaction (RT-PCR) was used for the confirmation of SARS-CoV-2 infection. The principles of spectrophotometry and chemiluminescent micro particle immunoassay (CMIA) were employed to estimate the levels of Glucose, TSH and 25-hydroxy vitamin D levels in serum of infected patients. Results: A total of 236 patients infected with SARS-CoV-2 were taken for this cross-sectional study. Patients with COVID-19 had a male predominance (72.9% vs 27.1%) and higher prevalence of 25-hydroxy vitamin D deficiency (72.0% vs 28.0%) with a mean 25-hydroxy vitamin D levels of 24.0±13.9 in ng/ml. We observed a varied clinical spectrum of SARS-CoV-2 infection with 36.4%, 23.7% and 29.7% patients having mild, moderate and severe disease respectively. We observed that severity of SARS-CoV-2 infection was significantly associated with older age group, hypertension, low TSH levels and 25-hydroxy vitamin D deficiency. Discussion/Conclusion: We conclude that not only old age but hypertension and low levels of TSH and 25 Hydroxy Vitamin D Levels could significantly lead to clinical severity of SARS-CoV-2 infection.
Conflict of interest statement The authors declare that there is no conflict of interest
Author Contribution Conceptualization: SAW, BG, MSK; Data curation: MSK; Formal analysis: SAW, BG, MSK; Funding acquisition: SM, IAB; Investigation: SAW, BG, MSK; Methodology: SAW, BG, MSK; Project administration: SM, IAB; Resources: SM; Software: MSK; Supervision: SM, IAB; Validation: MSK SM, IAB; Visualization: SAW, BG, MSK; Writing-original draft: MSK; Writing-review & editing: MSK, IAB; Approval of final manuscript: all authors.
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'abstract': '<jats:p>Introduction: The surge in novel severe acute respiratory syndrome coronavirus 2 '
'(SARS-CoV-2) infection leading to coronavirus disease-2019 (COVID-19) has overwhelmed the '
'health system. To help health-care workers and policy makers prioritize treatment and to '
'decrease the burden on health systems caused by COVID-19, clinical severity along with '
'various clinico-biochemical parameters was evaluated by designing a cross-sectional study '
'comprising 236 SARS-CoV-2-infected individuals from Kashmir Valley, India. Methods: Briefly, '
'real-time polymerase chain reaction (RT-PCR) was used for the confirmation of SARS-CoV-2 '
'infection. The principles of spectrophotometry and chemiluminescent microparticle immunoassay '
'(CMIA) were employed to estimate the levels of glucose, TSH, and 25-hydroxy vitamin D levels '
'in serum of infected patients. Results: A total of 236 patients infected with SARS-CoV-2 were '
'taken for this cross-sectional study. Patients with COVID-19 had a male predominance (72.9 '
'vs. 27.1%) and a higher prevalence of 25-hydroxy vitamin D deficiency (72.0 vs. 28.0%) with a '
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'spectrum of SARS-CoV-2 infection with 36.4%, 23.7%, and 29.7% patients having mild, moderate, '
'and severe disease, respectively. We observed that severity of SARS-CoV-2 infection was '
'significantly associated with older age group, hypertension, low TSH levels, and 25-hydroxy '
'vitamin D deficiency. Conclusion: We conclude that not only old age but also hypertension and '
'low levels of TSH and 25-hydroxy vitamin D levels could significantly lead to clinical '
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