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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Progression, all severe sym.. 23% treatment Improvement Relative Risk Case 9% treatment Case, first two weeks -12% treatment Case, last two weeks 54% treatment Time to viral- 11% no CI Case, >30ng/ml vs. ≤20n.. 23% levels Progression, fever -4% treatment Progression, sore throat 8% treatment Progression, rhinorrhea.. 42% treatment Progression, diarrhea 66% treatment Progression, vomiting -204% treatment Progression, cough 13% treatment Progression, muscle/join.. 48% treatment Progression, taste/smell -56% treatment Vitamin D  Wang et al.  Prophylaxis  RCT Is prophylaxis with vitamin D beneficial for COVID-19? RCT 202 patients in China (December 2022 - February 2023) Lower progression with vitamin D (not stat. sig., p=0.2) Wang et al., Elsevier BV, March 2023 Favors vitamin D Favors control

Influence of a High Vitamin D2 Dose on the Prevention and Improvement of Symptomatic COVID-19 in Health Care Workers: A Multicenter Randomized Clinical Trial

Wang et al., Elsevier BV, doi:10.2139/ssrn.4401710, NCT05673980
Mar 2023  
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RCT 214 low risk (no hospitalization) healthcare workers in China, showing no significant differences with short-term vitamin D2 prophylaxis.
Patients with higher vitamin D levels (across both groups) were less likely to be infected. The trial only lasted one month. Two thirds of the cases occurred within the first week, when treatment may have minimal impact on vitamin D levels (calcifediol or calcidiol may be more effective due to delays in conversion).
Cases were lower in the intervention group during the last two weeks, after treatment is likely to have increased levels significantly. Longer term or more effective adminstration (e.g., calcifediol/calcidiol) may be more effective.
We are not sure of the exact numbers because the supplementary table mentioned is currently unavailable and the numbers in the text are inconsistent. Authors report 50% cases in the vitamin D2 group and 54% control with a total of 104 cases in the ITT analysis, but no counts appear to match these numbers.
The study was registered retrospectively.
There was no mortality or hospitalization. 200,000 IU vitamin D2 fortnightly.
This is the 27th of 28 COVID-19 RCTs for vitamin D, which collectively show efficacy with p=0.0000081.
This is the 109th of 116 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 38 sextillion).
risk of progression, 22.6% lower, RR 0.77, p = 0.20, treatment 99, control 103, all severe symptoms below combined via meta analysis.
risk of case, 9.0% lower, RR 0.91, p = 0.57, treatment 49 of 99 (49.5%), control 56 of 103 (54.4%), NNT 21.
risk of case, 12.3% higher, RR 1.12, p = 0.56, treatment 41 of 99 (41.4%), control 38 of 103 (36.9%), first two weeks.
risk of case, 53.8% lower, RR 0.46, p = 0.06, treatment 8 of 99 (8.1%), control 18 of 103 (17.5%), NNT 11, last two weeks.
time to viral-, 10.8% lower, relative time 0.89, treatment 99, control 103.
risk of case, 22.7% lower, RR 0.77, p = 0.19, high D levels (≥30ng/ml) 20 of 44 (45.5%), low D levels (<20ng/ml) 50 of 85 (58.8%), NNT 7.5, outcome based on serum levels.
risk of progression, 4.0% higher, RR 1.04, p = 1.00, treatment 5 of 99 (5.1%), control 5 of 103 (4.9%), risk of severe case, fever.
risk of progression, 7.5% lower, RR 0.92, p = 1.00, treatment 8 of 99 (8.1%), control 9 of 103 (8.7%), NNT 152, risk of severe case, sore throat.
risk of progression, 42.2% lower, RR 0.58, p = 0.41, treatment 5 of 99 (5.1%), control 9 of 103 (8.7%), NNT 27, risk of severe case, rhinorrhea or congestion.
risk of progression, 66.2% lower, RR 0.34, p = 1.00, treatment 0 of 99 (0.0%), control 1 of 103 (1.0%), NNT 103, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), risk of severe case, diarrhea.
risk of progression, 204.0% higher, RR 3.04, p = 0.49, treatment 1 of 99 (1.0%), control 0 of 103 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), risk of severe case, vomiting.
risk of progression, 13.3% lower, RR 0.87, p = 0.82, treatment 10 of 99 (10.1%), control 12 of 103 (11.7%), NNT 65, risk of severe case, cough.
risk of progression, 48.0% lower, RR 0.52, p = 0.13, treatment 8 of 99 (8.1%), control 16 of 103 (15.5%), NNT 13, risk of severe case, muscle/joint aches.
risk of progression, 56.1% higher, RR 1.56, p = 0.68, treatment 3 of 99 (3.0%), control 2 of 103 (1.9%), risk of severe case, taste/smell.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wang et al., 29 Mar 2023, Randomized Controlled Trial, China, preprint, median age 36.5, 23 authors, study period 18 December, 2022 - 20 February, 2023, dosage 200,000IU days 1, 14, trial NCT05673980 (history).
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This PaperVitamin DAll
Influence of a High Vitamin D2 Dose on the Prevention and Improvement of Symptomatic COVID-19 in Health Care Workers: A Multicenter Randomized Clinical Trial
Huan Wang, PhD Liyuan Tao, Liyan Cui, Yahong Chen, Dongyang Liu, Lixiang Xue, Yuping Yang, Yang Lv, Fuchun Zhang, Tiancheng Wang, Xiaoxiao Wang, Wanqiong Yuan, Hao Liu, Jie Huang, Yanfang Jiang, Na Liu, Lijuan Yang, Yunjing Hu, Yanfang Li, Yuling Gao, Dr Haiyan Li, Baohua Li, PhD Chun-Li Song
Background COVID-19 pandemic exacerbates infections among health care workers, highlighting importance of prevention for these high-risk people. Vitamin D, as an immunomodulator, is thought likely to be to correlate with the inflammatory reaction. Methods This was a multicenter, open-label, randomized controlled trial. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to 200, 000 IU vitamin D2 fortnightly or non-intervention at a ratio 1:1. PCR or antigen tests were taken at baseline and twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines (IL-1β, IFN-α, IFN-
Article Information Corresponding Author: Chunli Song, Baohua Li, Haiyan Li This preprint research paper has not been peer reviewed. Electronic copy available at: P r e p r i n t n o t p e e r r e v i e w e d Conflict of Interest Disclosures: The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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