Influence of a High Vitamin D2 Dose on the Prevention and Improvement of Symptomatic COVID-19 in Health Care Workers: A Multicenter Randomized Clinical Trial
Huan Wang, PhD Liyuan Tao, Liyan Cui, Yahong Chen, Dongyang Liu, Lixiang Xue, Yuping Yang, Yang Lv, Fuchun Zhang, Tiancheng Wang, Xiaoxiao Wang, Wanqiong Yuan, Hao Liu, Jie Huang, Yanfang Jiang, Na Liu, Lijuan Yang, Yunjing Hu, Yanfang Li, Yuling Gao, Dr Haiyan Li, Baohua Li, PhD Chun-Li Song
Background COVID-19 pandemic exacerbates infections among health care workers, highlighting importance of prevention for these high-risk people. Vitamin D, as an immunomodulator, is thought likely to be to correlate with the inflammatory reaction.
Methods This was a multicenter, open-label, randomized controlled trial. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to 200, 000 IU vitamin D2 fortnightly or non-intervention at a ratio 1:1. PCR or antigen tests were taken at baseline and twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines (IL-1β, IFN-α, IFN-
Article Information Corresponding Author: Chunli Song, Baohua Li, Haiyan Li This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=4401710 P r e p r i n t n o t p e e r r e v i e w e d
Conflict of Interest Disclosures: The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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