Conv. Plasma
Nigella Sativa

All vitamin K studies
Meta analysis
study COVID-19 treatment researchVitamin KVitamin K (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   All Outcomes    Recent:   

Vitamin D - contrary to vitamin K - does not associate with clinical outcome in hospitalized COVID-19 patients

Walk et al., medRxiv, doi:10.1101/2020.11.07.20227512
Nov 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Small retrospective study of 135 patients not finding a significant difference in vitamin D status. Patients with good outcomes had a median of 45.0 nmol/L versus 37.7 nmol/L for bad outcomes, p = 0.85. Authors found that vitamin D sufficient persons had accelerated elastic fiber degradation, they hypothesize pro-calcification effects during COVID-19 and that vitamin K might compensate for this.
Study covers vitamin K and vitamin D.
Walk et al., 9 Nov 2020, retrospective, Netherlands, preprint, 5 authors.
This PaperVitamin KAll
Vitamin D – contrary to vitamin K – does not associate with clinical outcome in hospitalized COVID-19 patients
Jona Walk, Anton S M Dofferhoff, Jody M W Van Den Ouweland, Henny Van Daal, Dr Rob Janssen
SARS-CoV-2 causes remarkably variable disease from asymptomatic individuals to respiratory insufficiency and coagulopathy. Vitamin K deficiency was recently found to associate with clinical outcome in a cohort of COVID-19 patients. Vitamin D has been hypothesized to reduce disease susceptibility by modulating inflammation, yet little is known about its role in disease severity. Considering the critical interaction between vitamin K and vitamin D in calcium and elastic fiber metabolism, we determined vitamin D status in the same cohort of 135 hospitalized COVID-19 patients by measuring blood 25(OH)D levels. We found no difference in vitamin D status between those with good and poor outcome (defined as intubation and/or death). Instead, we found vitamin D sufficient persons (25(OH)D >50 nmol/L) had accelerated elastic fiber degradation compared to those with mild deficiency (25(OH)D 25-50 nmol/L). Based on these findings, we hypothesize that vitamin D might have both favorable anti-inflammatory and unfavorable pro-calcification effects during COVID-19 and that vitamin K might compensate for the latter.
Basalyga, Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases, Circulation
Boraldi, The mineralization process of insoluble elastin fibrillar structures: Ionic environment vs degradation, Int J Biol Macromol
Bouvet, Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis, Arterioscler Thromb Vasc Biol
Cipriani, Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study, J Clin Endocrinol Metab
D'avolio, 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2, Nutrients
Dirks, Various calibration procedures result in optimal standardization of routinely used 25(OH)D ID-LC-MS/MS methods, Clin Chim Acta
Dofferhoff, Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19, Clin Infect Dis
Fraser, Price, Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells, Calcif Tissue Int
Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients
Hastie, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr
Honardoost, Ghavideldarestani, Khamseh, Role of vitamin D in pathogenesis and severity of COVID-19 infection, Arch Physiol Biochem
Janssen, Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019, Br J Nutr
Janssens, Vitamin D and chronic obstructive pulmonary disease: hype or reality?, Lancet Respir Med
Lee, Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses, Am J Pathol
Luo, Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein, Nature
Martineau, Forouhi, Vitamin D for COVID-19: a case to answer?, Lancet Diabetes Endocrinol
Mccann, Ames, Vitamin, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?, Am J Clin Nutr
Mehta, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, Lancet
Niederhoffer, Aortic calcification produced by vitamin D3 plus nicotine, J Vasc Res
Panagiotou, Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clin Endocrinol
Price, Buckley, Williamson, The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats, J Nutr
Rucker, Calcium binding to elastin, Adv Exp Med Biol
Schurgers, Uitto, Reutelingsperger, Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization, Trends Mol Med
Turino, Matrix elastin: a promising biomarker for chronic obstructive pulmonary disease, Am J Respir Crit Care Med
Ueland, Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure, J Infect
Van Ballegooijen, Joint association of vitamins D and K status with longterm outcomes in stable kidney transplant recipients, Nephrol Dial Transplant
Van Ballegooijen, The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review, Int J Endocrinol
Winter, High prevalence of vitamin D deficiency in the south-west Netherlands
Zweifler, Esler, Factors influencing the choice of antihypertensive agents, Postgrad Med
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop