The Effect of Vitamin D treatment on COVID 19- Patients, an Inverted Propensity Score Weighting (IPSW), and Inverted Probability of Treatment Weighting (IPTW) Analyzed Study
Jamal Wadi Al Ramahi, Nour Hasan, Amal Matar, Ma'en Maher Al-Ali, Lara Abdulhadi, Dania Abu Kaf, Waseem Saadeh, Nour Hamdan, Hassan Abukhalaf, Mohamed Gharaibeh, Hanadi Hamadallah, Ala'a Bader, Mohammad Atout, Sae’ed Moh. Mar’i, Tamer Alhamed
The International Arabic Journal of Antimicrobial Agents, doi:10.3823/862
Background: Vitamin D3 (1,25(OH) 2 cholecalciferol) as a treatment for COVID 19 patients is being disputed, and a clear clinical benefit is not being confirmed.
Methods: A retrospective evaluation for COVID-19 patients who were treated with various cumulative doses of vitamin D. Data was extracted from the COVID-19 database, it included patients admitted to three hospitals in Amman, Jordan. Characteristics of patients were tabulated and compared for all-cohort, and propensity score index (PSI) adjustment. The comparison was based on two vitamin D strata (≤ 149,000 i.u. and > 150,000 i.u.). Logistic regression analysis was utilized to predict recovery, the need for oxygen, and all-cause mortality for all-cohort, IPSW, and IPTW patients, based on vitamin D cumulative doses during their hospital stay. Results: 1131 all-cohort and 768 PSI-adjusted patients were recruited. Except for antibiotics and antivirals, all other characteristics were balanced (P = NS). There were 1017 patients on vitamin D, 847 received cumulative ≤ 149,000 i.u., and 170 patients received cumulative dose
The Journal is an open access peer-reviewed journal that publishes scientific papers about all aspects of antimicrobials. The journal will publish original research articles, reviews, brief reports and case reports dealing with basic and clinical antibacterial agents, antiviral, antiprotozoals, antituberculuous, antifungal and antihelminthes agents. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online. The journal aims to advance the knowledge, attitude and the research of chemotherapy in the Arabic world in cooperation with international, national scientific and public societies as well as research centers with similar aims and objectives.
References
Alanagreh, Alzoughool, Atoum, The human coronavirus disease COVID-19: its origin, characteristics, and insights into potential drugs and its mechanisms, Pathogens
Annweiler, Hanotte, De L'eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: a quasi-experimental study, The Journal of Steroid Biochemistry and Molecular Biology
Balcells, Rojas, Corre, Martínez-Valdebenito, Ceballos et al., Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial, PLoS Medicine
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, The Journal of Steroid Biochemistry and Molecular Biology
Dubnov-Raz, Hemilä, Cohen, Rinat, Choleva et al., Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial, Pediatric Exercise Science
Faqihi, Alharthy, Alodat, Asad, Aletreby et al., A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): a structured summary of a randomized controlled trial study protocol, Trials
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PloS One
Marik, Kory, Varon, Iglesias, Meduri, MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale, Expert Review of Anti-infective Therapy
Nittari, Pallotta, Amenta, Tayebati, Current pharmacological treatments for SARS-COV-2: A narrative review, European Journal of Pharmacology
Panfili, Roversi, Rossi, Cappa, Fintini, Possible role of vitamin D in Covid-19 infection in pediatric population, Journal of Endocrinological Investigation
Science, Maguire, Russell, Smieja, Walter et al., Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents, Clinical Infectious Diseases
Sundaram, Coleman, Vitamin D and influenza, Advances in Nutrition
Thomas, Patel, Bittel, Wolski, Wang et al., Effect of highdose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial, JAMA Network Open
Urashima, Takaakisegawa, Okazaki, Kurihara, Wada et al., Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren, The American Journal of Clinical Nutrition
Wong, Lam, Fong, Leung, Chin et al., Frequency and distribution of chest radiographic findings in patients positive for COVID-19, Radiology
