The Effect of Vitamin D treatment on COVID 19- Patients, an Inverted Propensity Score Weighting (IPSW), and Inverted Probability of Treatment Weighting (IPTW) Analyzed Study
Wadi Al Ramahi et al., The International Arabic Journal of Antimicrobial Agents,
doi:10.3823/862
Wadi Al Ramahi et al.,
The Effect of Vitamin D treatment on COVID 19- Patients, an Inverted Propensity Score Weighting (IPSW), and..,
The International Arabic Journal of Antimicrobial Agents, doi:10.3823/862
Retrospective study comparing 847 patients receiving ≤149,000IU vitamin D and 170 receiving ≥150,000IU, showing no significant differences, however the result may not be very meaningful - membership in the higher cumulative dose group requires longer hospitalization, e.g., patients discharged shortly after admission (a positive outcome) could not be in the higher cumulative dose group.
Wadi Al Ramahi et al., 7 Mar 2022, peer-reviewed, 15 authors.
Abstract: iMedPub Journals
http://journals.imed.pub
The International Arabic Journal of Antimicrobial Agents
ISSN: 2174-9094
2022
Vol. 12 No. 1:2
doi: 10.3823/862
The effect of vitamin D Treatment on COVID 19patients, an inverted propensity score weighting
(IPSW), and inverted probability of treatment
weighting (IPTW) analyzed study
Jamal Wadi Al Ramahi1, Nour Hasan2,
Ammal Matar2, Ma'en Maher Al-Ali3,
Lara Abdulhadi2, Dania Abu Kaf3, Waseem Saadeh4,
Nour Hamdan4, Hassan AbuKhalaf4,
Mohamed Gharaibeh5, Hanadi Hamadallah6,
Ala'abader7, Mohammad Atout4, Sae’ed Moh. Mar’I4,
Tamer Alhamed4
Abstract
1 Department of Medicine, School of
Medicine, The University of Jordan.
Amman, Jordan.
2 Al Khalidi Hospital, Clinical Pharmacy,
Amman, Jordan.
3 Department of Clinical Medical
Sciences, Faculty of Medicine, Yarmouk
University, Irbid, Jordan.
4 Department of Medicine. The Specialty
Hospital. Amman, Jordan.
5 Department of Anesthesia, The
Specialty Hospital. Amman, Jordan.
6 Jordan hospital, Department of
Pharmacy. Amman, Jordan.
7 The Specialty hospital. Department of
pharmacy. Amman, Jordan.
Background: Vitamin D3 (1,25(OH)2cholecalciferol) as a treatment for
Contact information:
COVID 19 patients is being disputed, and a clear clinical benefit is not
being confirmed.
Methods: A retrospective evaluation for COVID-19 patients who were
treated with various cumulative doses of vitamin D. Data was extracted from the COVID-19 database, it included patients admitted to
three hospitals in Amman, Jordan. Characteristics of patients were
tabulated and compared for all-cohort, and propensity score index
(PSI) adjustment. The comparison was based on two vitamin D strata
(≤ 149,000 i.u. and > 150,000 i.u.). Logistic regression analysis was
utilized to predict recovery, the need for oxygen, and all-cause mortality for all-cohort, IPSW, and IPTW patients, based on vitamin D
cumulative doses during their hospital stay.
Jamal Wadi Al Ramahi, MD, FIDSA.
jamalwadimd@yahoo.com
Results: 1131 all-cohort and 768 PSI-adjusted patients were recruited.
Except for antibiotics and antivirals, all other characteristics were balanced (P = NS). There were 1017 patients on vitamin D, 847 received
cumulative ≤ 149,000 i.u., and 170 patients received cumulative dose
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1
The International Arabic Journal of Antimicrobial Agents
ISSN: 2174-9094
≥ 150,000 i.u. (Range 1000 – 385000). It was demonstrated that the
escalation of the cumulative doses of vitamin D did not contribute
to the assessed outcomes; all-cohort patients (OR = 1.000, 95% C.I.
1.000 to 1.000), IPSW (OR = 1.000, 95% C.I. 1.000 to 1.000), and
the IPTW (OR = 1.000, 95% C.I. 1.000 to 1.000).
Conclusion: In our patients’ cohorts, we could not demonstrate a
beneficial effect for vitamin D therapy in COVID-19 patients in recovery, the need for home oxygen, and all-cause mortality, by hospital
discharge.
Late treatment
is less effective
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