Abstract: iMedPub Journals http://journals.imed.pub The International Arabic Journal of Antimicrobial Agents ISSN: 2174-9094 2022 Vol. 12 No. 1:2 doi: 10.3823/862 The effect of vitamin D Treatment on COVID 19patients, an inverted propensity score weighting (IPSW), and inverted probability of treatment weighting (IPTW) analyzed study Jamal Wadi Al Ramahi1, Nour Hasan2, Ammal Matar2, Ma'en Maher Al-Ali3, Lara Abdulhadi2, Dania Abu Kaf3, Waseem Saadeh4, Nour Hamdan4, Hassan AbuKhalaf4, Mohamed Gharaibeh5, Hanadi Hamadallah6, Ala'abader7, Mohammad Atout4, Sae’ed Moh. Mar’I4, Tamer Alhamed4 Abstract 1 Department of Medicine, School of Medicine, The University of Jordan. Amman, Jordan. 2 Al Khalidi Hospital, Clinical Pharmacy, Amman, Jordan. 3 Department of Clinical Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan. 4 Department of Medicine. The Specialty Hospital. Amman, Jordan. 5 Department of Anesthesia, The Specialty Hospital. Amman, Jordan. 6 Jordan hospital, Department of Pharmacy. Amman, Jordan. 7 The Specialty hospital. Department of pharmacy. Amman, Jordan. Background: Vitamin D3 (1,25(OH)2cholecalciferol) as a treatment for Contact information: COVID 19 patients is being disputed, and a clear clinical benefit is not being confirmed. Methods: A retrospective evaluation for COVID-19 patients who were treated with various cumulative doses of vitamin D. Data was extracted from the COVID-19 database, it included patients admitted to three hospitals in Amman, Jordan. Characteristics of patients were tabulated and compared for all-cohort, and propensity score index (PSI) adjustment. The comparison was based on two vitamin D strata (≤ 149,000 i.u. and > 150,000 i.u.). Logistic regression analysis was utilized to predict recovery, the need for oxygen, and all-cause mortality for all-cohort, IPSW, and IPTW patients, based on vitamin D cumulative doses during their hospital stay. Jamal Wadi Al Ramahi, MD, FIDSA. jamalwadimd@yahoo.com Results: 1131 all-cohort and 768 PSI-adjusted patients were recruited. Except for antibiotics and antivirals, all other characteristics were balanced (P = NS). There were 1017 patients on vitamin D, 847 received cumulative ≤ 149,000 i.u., and 170 patients received cumulative dose © Under License of Creative Commons Attribution 3.0 License This article is available at: www.iajaa.org 1 The International Arabic Journal of Antimicrobial Agents ISSN: 2174-9094 ≥ 150,000 i.u. (Range 1000 – 385000). It was demonstrated that the escalation of the cumulative doses of vitamin D did not contribute to the assessed outcomes; all-cohort patients (OR = 1.000, 95% C.I. 1.000 to 1.000), IPSW (OR = 1.000, 95% C.I. 1.000 to 1.000), and the IPTW (OR = 1.000, 95% C.I. 1.000 to 1.000). Conclusion: In our patients’ cohorts, we could not demonstrate a beneficial effect for vitamin D therapy in COVID-19 patients in recovery, the need for home oxygen, and all-cause mortality, by hospital discharge.