Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency

Tomasa-Irriguible et al., MDPI AG, doi:10.20944/preprints202009.0555.v1
Sep 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 35 ICU patients in Spain showing 71% of patients had vitamin D levels <20 ng/mL, and 40% <10 ng/mL.
Tomasa-Irriguible et al., 23 Sep 2020, retrospective, preprint, 2 authors. Contact: teresatomasa@gmail.com (corresponding author), larabielsa@gmail.com, luisabordeje@gmail.com.
This PaperVitamin DAll
Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency
Teresa-Maria Tomasa-Irriguible, Lara Bielsa-Berrocal
doi:10.20944/preprints202009.0555.v1
Background: Coronavirus disease (COVID-19) has caused more than 745,000 deaths worldwide. Vitamin D has been identified as a potential strategy to prevent or treat this disease. The purpose of the study was to measure vitamin D at hospital admission of COVID-19; Methods: We included critically ill patients with the polymerase chain reaction positive test for COVID-19, from March to April, 2020. Statistical significance was defined as P < .05. All tests were 2-tailed; Results: A total of 35 patients (median age, 60 years; 26 [74.3%] male) were included. Vitamin D levels were categorized as deficient for 14 participants (40%). Vitamin D deficiency was associated with vitamin A (P= 0.003) and Zinc (P= 0.019) deficiency and lower levels of albumin (P= 0.026) and prealbumin (P= 0.009). Overall, none of the studied variables were associated with vitamin D status: mortality, intensive care unit (ICU) or hospital stay, necessity of vasoactive agents, intubation, prone position, C reactive protein (CRP), Dimer-D, Interleukin 6 levels (IL-6), ferritin levels, or bacterial superinfection; Conclusions: In this single-center, retrospective cohort study, deficient vitamin D status was found in 40% in COVID-19 critically ill patients. However, deficient vitamin D status was not associated with inflammation or outcome.
Conflicts of Interest: The authors declare no conflict of interest.
References
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J Infect Public Health, doi:10.1016/j.jiph.2020.06.021
Ards Definition, Force, Ranieri, Rubenfeld, Thompson et al., Acute respiratory distress syndrome: the Berlin definition, JAMA
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, Journal of Steroid Biochemistry and Molecular Biology
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7
Fan, Brodie, Slutsky, Acute respiratory distress syndrome, JAMA, doi:10.1001/jama.2017.21907
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Laird, Rhodes, Kenny, Vitamin, And inflammation: potential implications for severity of Covid-19, Ir. Med. J
Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity, Clin. Endocrinol, doi:10.1111/cen.14276
Ranieri, Rubenfeld, Thompson, Ferguson, Caldwell et al., Acute respiratory distress syndrome: the Berlin definition, JAMA -J. Am. Med. Assoc, doi:10.1001/jama.2012.5669
Russo, Carlucci, Cipriani, Ragno, Piemonte et al., Metabolic changes following 500 μg monthly administration of calcidiol: a study in normal females, Calcif. Tissue Int, doi:10.1007/s00223-011-9513-1
Viechtbauer, Smits, Kotz, Bud´e, Spigt et al., A simple formula for the calculation of sample size in pilot studies, J. Clin. Epidemiol, doi:10.1016/j.jclinepi.2015.04.014
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan, China, JAMA Intern. Med, doi:10.1001/jamainternmed.2020.0994
Yin, Agrawal, Vitamin D and inflammatory diseases, J Inflamm Res, doi:10.2147/JIR.S63898
{ 'indexed': {'date-parts': [[2022, 3, 29]], 'date-time': '2022-03-29T04:32:51Z', 'timestamp': 1648528371860}, 'posted': {'date-parts': [[2020, 9, 23]]}, 'group-title': 'MEDICINE &amp; PHARMACOLOGY', 'reference-count': 0, 'publisher': 'MDPI AG', 'license': [ { 'start': { 'date-parts': [[2020, 9, 23]], 'date-time': '2020-09-23T00:00:00Z', 'timestamp': 1600819200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 9, 22]]}, 'abstract': '<jats:p>Background: Coronavirus disease (COVID-19) has caused more than 745,000 deaths ' 'worldwide. Vitamin D has been identified as a potential strategy to prevent or treat this ' 'disease. The purpose of the study was to measure vitamin D at hospital admission of COVID-19; ' 'Methods: We included critically ill patients with the polymerase chain reaction positive test ' 'for COVID-19, from March to April, 2020. Statistical significance was defined as P ' '&amp;amp;lt; .05. All tests were 2-tailed; Results: A total of 35 patients (median age, 60 ' 'years; 26 [74.3%] male) were included. Vitamin D levels were categorized as deficient for 14 ' 'participants (40%). Vitamin D deficiency was associated with vitamin A (P= 0.003) and Zinc ' '(P= 0.019) deficiency and lower levels of albumin (P= 0.026) and prealbumin (P= 0.009). ' 'Overall, none of the studied variables were associated with vitamin D status: mortality, ' 'intensive care unit (ICU) or hospital stay, necessity of vasoactive agents, intubation, prone ' 'position, C reactive protein (CRP), Dimer-D, Interleukin 6 levels (IL-6), ferritin levels, or ' 'bacterial superinfection; Conclusions: In this single-center, retrospective cohort study, ' 'deficient vitamin D status was found in 40% in COVID-19 critically ill patients. However, ' 'deficient vitamin D status was not associated with inflammation or outcome.</jats:p>', 'DOI': '10.20944/preprints202009.0555.v1', 'type': 'posted-content', 'created': {'date-parts': [[2020, 9, 24]], 'date-time': '2020-09-24T10:02:37Z', 'timestamp': 1600941757000}, 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency', 'prefix': '10.20944', 'author': [ { 'given': 'Teresa-Maria', 'family': 'Tomasa-Irriguible', 'sequence': 'first', 'affiliation': []}, {'given': 'Lara', 'family': 'Bielsa-Berrocal', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'container-title': [], 'original-title': [], 'deposited': { 'date-parts': [[2020, 9, 24]], 'date-time': '2020-09-24T12:33:42Z', 'timestamp': 1600950822000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.preprints.org/manuscript/202009.0555/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 9, 23]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.20944/preprints202009.0555.v1', 'relation': {}, 'published': {'date-parts': [[2020, 9, 23]]}, 'subtype': 'preprint'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit