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Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency

Tomasa-Irriguible et al., MDPI AG, doi:10.20944/preprints202009.0555.v1
Sep 2020  
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Retrospective 35 ICU patients in Spain showing 71% of patients had vitamin D levels <20 ng/mL, and 40% <10 ng/mL.
Tomasa-Irriguible et al., 23 Sep 2020, retrospective, preprint, 2 authors.
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Up to 40% of COVID-19 Critically Ill Patients Have Vitamin D Deficiency
Teresa-Maria Tomasa-Irriguible, Lara Bielsa-Berrocal
Background: Coronavirus disease (COVID-19) has caused more than 745,000 deaths worldwide. Vitamin D has been identified as a potential strategy to prevent or treat this disease. The purpose of the study was to measure vitamin D at hospital admission of COVID-19; Methods: We included critically ill patients with the polymerase chain reaction positive test for COVID-19, from March to April, 2020. Statistical significance was defined as P < .05. All tests were 2-tailed; Results: A total of 35 patients (median age, 60 years; 26 [74.3%] male) were included. Vitamin D levels were categorized as deficient for 14 participants (40%). Vitamin D deficiency was associated with vitamin A (P= 0.003) and Zinc (P= 0.019) deficiency and lower levels of albumin (P= 0.026) and prealbumin (P= 0.009). Overall, none of the studied variables were associated with vitamin D status: mortality, intensive care unit (ICU) or hospital stay, necessity of vasoactive agents, intubation, prone position, C reactive protein (CRP), Dimer-D, Interleukin 6 levels (IL-6), ferritin levels, or bacterial superinfection; Conclusions: In this single-center, retrospective cohort study, deficient vitamin D status was found in 40% in COVID-19 critically ill patients. However, deficient vitamin D status was not associated with inflammation or outcome.
Conflicts of Interest: The authors declare no conflict of interest.
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