Summary of COVID-19 plitidepsin studies
Studies
Meta Analysis
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RCT with 205 hospitalized moderate COVID-19 patients showing a trend towards faster time to sustained withdrawal of oxygen supplementation with plitidepsin treatment (1.5 mg/day or 2.5 mg/day for 3 days) compared to standard of care. The trial was terminated early due to a drop in COVID-19-related hospitalizations. Plitidepsin was generally well tolerated.
Aug 2024, Clinical Infectious Diseases, https://academic.oup.com/cid/article/79/4/910/7740910, https://c19p.org/landete
37 patient plitidepsin late treatment RCT: 36% higher mortality (p=1).
RCT 37 hospitalized immunocompromised patients, showing no significant benefit with plitidepsin treatment.
Dec 2024, PharmaMar, NCT05705167, https://clinicaltrials.gov/study/NCT05705167, https://c19p.org/pharmamar
1. Landete et al., A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
137 patient plitidepsin late treatment RCT: 1% lower mortality (p=1).RCT with 205 hospitalized moderate COVID-19 patients showing a trend towards faster time to sustained withdrawal of oxygen supplementation with plitidepsin treatment (1.5 mg/day or 2.5 mg/day for 3 days) compared to standard of care. The trial was terminated early due to a drop in COVID-19-related hospitalizations. Plitidepsin was generally well tolerated.
Aug 2024, Clinical Infectious Diseases, https://academic.oup.com/cid/article/79/4/910/7740910, https://c19p.org/landete
37 patient plitidepsin late treatment RCT: 36% higher mortality (p=1).
RCT 37 hospitalized immunocompromised patients, showing no significant benefit with plitidepsin treatment.
Dec 2024, PharmaMar, NCT05705167, https://clinicaltrials.gov/study/NCT05705167, https://c19p.org/pharmamar
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