The effects of mouth rinsing and gargling with mouthwash containing povidone-iodine and hydrogen peroxide on the cycle threshold value of Severe Acute Respiratory Syndrome Coronavirus 2: A randomized controlled trial of asymptomatic and mildly symptomatic patients

{ 'indexed': { 'date-parts': [[2022, 11, 12]], 'date-time': '2022-11-12T05:59:10Z', 'timestamp': 1668232750605}, 'reference-count': 44, 'publisher': 'F1000 Research Ltd', 'license': [ { 'start': { 'date-parts': [[2022, 11, 1]], 'date-time': '2022-11-01T00:00:00Z', 'timestamp': 1667260800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['f1000research.com'], 'crossmark-restriction': False}, 'abstract': '<ns4:p><ns4:bold>Background:</ns4:bold> Coronavirus disease 2019 can spread rapidly. Surgery ' 'in the oral cavity poses a high risk of transmission of severe acute respiratory syndrome ' 'coronavirus 2. The American Dental Association and the Centers for Disease Control and ' 'Prevention recommend the use of mouthwash containing 1.5% hydrogen peroxide ' '(H<ns4:sub>2</ns4:sub>O<ns4:sub>2</ns4:sub>) or 0.2% povidone iodine (PI) to reduce the viral ' 'load in the upper respiratory tract and decrease the risk of transmission. The aim of the ' 'present study was to analyze the effect of mouth rinsing and gargling with mouthwash ' 'containing 1% PI, 0.5% PI, 3% H<ns4:sub>2</ns4:sub>O<ns4:sub>2</ns4:sub>, or 1.5% ' 'H<ns4:sub>2</ns4:sub>O<ns4:sub>2</ns4:sub> and water on the cycle threshold (CT) value ' 'obtained by real-time reverse transcription polymerase chain reaction ' '(RT-PCR).</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> This study is a randomized single ' 'blind controlled clinical trial which has been registered in the International Standard ' 'Randomized Controlled Trial Number (ISRCTN) registry on the 3<ns4:sup>rd</ns4:sup> February ' '2022 (Registration number: ISRCTN18356379). In total, 69 subjects recruited from Persahabatan ' 'General Hospital who met the inclusion criteria were randomly assigned to one of four ' 'treatment groups or the control group. The subjects were instructed to gargle with 15 mL of ' 'mouthwash for 30 s in the oral cavity followed by 30 s in the back of the throat, three times ' 'per day for 5 days. CT values were collected on postprocedural days 1, 3, and ' '5.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> The results of the Friedman test ' 'significantly differed among the groups (n=15). The CT values increased from baseline (day 0) ' 'to postprocedural days 1, 3, and 5.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Mouth ' 'rinsing and gargling with mouthwash containing 1% PI, 0.5% PI, 3% ' 'H<ns4:sub>2</ns4:sub>O<ns4:sub>2</ns4:sub>, or 1.5% ' 'H<ns4:sub>2</ns4:sub>O<ns4:sub>2</ns4:sub> and water increased the CT value.</ns4:p>', 'DOI': '10.12688/f1000research.110843.1', 'type': 'journal-article', 'created': {'date-parts': [[2022, 11, 1]], 'date-time': '2022-11-01T11:50:09Z', 'timestamp': 1667303409000}, 'page': '1238', 'update-policy': 'http://dx.doi.org/10.12688/f1000research.crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The effects of mouth rinsing and gargling with mouthwash containing povidone-iodine and hydrogen ' 'peroxide on the cycle threshold value of Severe Acute Respiratory Syndrome Coronavirus 2: A ' 'randomized controlled trial of asymptomatic and mildly symptomatic patients', 'prefix': '10.12688', 'volume': '11', 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