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0 0.5 1 1.5 2+ Improvement in Ct value 6% Improvement Relative Risk Improvement in Ct value (b) 11% Povidone-Iodine  Sulistyani et al.  EARLY TREATMENT  RCT Is early treatment with povidone-iodine beneficial for COVID-19? RCT 30 patients in Indonesia (July - September 2021) No significant difference in viral clearance Sulistyani et al., F1000Research, March 2022 Favors povidone-iodine Favors control

The effects of mouth rinsing and gargling with mouthwash containing povidone-iodine and hydrogen peroxide on the cycle threshold value of Severe Acute Respiratory Syndrome Coronavirus 2: A randomized controlled trial of asymptomatic and mildly symptomatic patients

Sulistyani et al., F1000Research, doi:10.12688/f1000research.110843.1 (date from preprint)
Mar 2022  
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Small mouth rinsing and gargling RCT with 15 1% PVP-I, 12 0.5% PVP-I, 15 3% hydrogen peroxide, 12 1.5% hydrogen peroxide, and 15 water patients, showing rapid improvement in Ct value in all groups, and no significant differences between groups.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
relative improvement in Ct value, 6.3% better, RR 0.94, p = 0.74, treatment mean 12.905 (±5.96) n=15, control mean 12.088 (±7.38) n=15, 1% PVP-I vs. water, day 5.
relative improvement in Ct value, 11.3% better, RR 0.89, p = 0.54, treatment mean 13.628 (±6.28) n=15, control mean 12.088 (±7.38) n=15, 0.5% PVP-I vs. water, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sulistyani et al., 15 Mar 2022, Single Blind Randomized Controlled Trial, Indonesia, peer-reviewed, 9 authors, study period July 2021 - September 2021.
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This PaperPovidone-Iod..All
The effects of mouth rinsing and gargling with mouthwash containing povidone-iodine and hydrogen peroxide on the cycle threshold value of Severe Acute Respiratory Syndrome Coronavirus 2: A randomized controlled trial of asymptomatic and mildly symptomatic patients
Lilies Dwi Sulistyani, Vera Julia, Andrianto Soeprapto, Rumartha Putri Swari, Febriadi Rosmanato, Budi Haryanto, Cahyarini Cahyarini, Rinaldi Panjaitan, Diah Ayu Maharani
F1000Research, doi:10.12688/f1000research.110843.1
Background: Coronavirus disease 2019 can spread rapidly. Surgery in the oral cavity poses a high risk of transmission of severe acute respiratory syndrome coronavirus 2. The American Dental Association and the Centers for Disease Control and Prevention recommend the use of mouthwash containing 1.5% hydrogen peroxide (H 2 O 2 ) or 0.2% povidone iodine (PI) to reduce the viral load in the upper respiratory tract and decrease the risk of transmission. The aim of the present study was to analyze the effect of mouth rinsing and gargling with mouthwash containing 1% PI, 0.5% PI, 3% H 2 O 2 , or 1.5% H 2 O 2 and water on the cycle threshold (CT) value obtained by real-time reverse transcription polymerase chain reaction (RT-PCR). Methods: This study is a randomized single blind controlled clinical trial which has been registered in the International Standard Randomized Controlled Trial Number (ISRCTN) registry on the 3 rd February 2022 (Registration number: ISRCTN18356379). In total, 69 subjects recruited from Persahabatan General Hospital who met the inclusion criteria were randomly assigned to one of four treatment groups or the control group. The subjects were instructed to gargle with 15 mL of mouthwash for 30 s in the oral cavity followed by 30 s in Open Peer Review Approval Status AWAITING PEER REVIEW Any reports and responses or comments on the article can be found at the end of the article.
Data are available under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0). Author contributions • Lilies Dwi Sulistyani conceived and designed the analysis, verified the analytical methods, gaining resources, supervised the study, in charge of overall direction and planning, wrote and revised the paper • Vera Julia conceived and designed the analysis, verified the analytical methods, supervised the study, wrote and revised the paper • Andrianto Soeprapto performed the experiment and analysis, drafted and revised the paper • Rumartha Putri Swari performed the experiment and analysis, drafted the paper • Febriadi Rosmanato performed the experiment and analysis, drafted the paper
Akhter, Akhtar, Emerging Coronavirus Diseases and Future Perspectives, Virus Dis
Anderson, Sivalingam, Kang, Povidone-Iodine Demonstrates Rapid in vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease, Infect Dis Ther
Astuti, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An Overview of Viral Structure and Host Response, Diabetes Metab Syndr
Bidra, Pelletier, Westover, Comparison of in vitro Inactivation of SARS CoV-2 With Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses, J Prosthodont, doi:10.1111/jopr.13220
Buchta, Görzer, Chiba, Variability of Cycle Threshold Values in an External Quality Assessment Scheme for Detection of the SARS-CoV-2 Virus Genome by RT-PCR, Clin Chem Lab Med
Carrouel, Gonçalves, Conte, Antiviral Activity of Reagents in Mouth Rinses Against SARS-CoV-2, J Dent Res
Caruso, Prete, Lazzarino, Hydrogen Peroxide and Viral Infections: A Literature Review With Research Hypothesis Definition in Relation to the Current Covid-19 Pandemic, Med Hypo
Casale, Rinaldi, Sabatino, Could Nasal Irrigation and Oral Rinse Reduce the Risk for COVID-19 Infection?, Int J Immunopathol Pharmacol, doi:10.1177/2058738420941757
Cevik, Kuppalli, Kindrachuk, Virology, Transmission, and Pathogenesis of SARS-CoV-2, BMJ, doi:10.1136/bmj.m3862
Chen, Zhao, Peng, Detection of SARS-CoV-2 in Saliva and Characterization of Oral Symptoms in COVID-19 Patients, Cell Prolif, doi:10.1111/cpr.12923
Donnell, Thomas, Stanton, Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2
Eggers, Koburger-Janssen, Eickmann, In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/ Mouthwash Against Respiratory and Oral Tract Pathogens, Infect Dis Ther
Era, None, Ear Nose Throat J
Fernández-Rodríguez, Casas, Culebras, COVID-19 and Post-Mortem Microbiological Studies, Rev Esp Med Leg, doi:10.1016/j.remle.2020.05.007
Frank, Capriotti, Brown, Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19
Gao, Xu, Sun, A Systematic Review of Asymptomatic Infections With COVID-19, J Microbiol Immunol Infect, doi:10.1016/j.jmii.2020.05.001
Gottsauner, Michaelides, Schmidt, A Prospective Clinical Pilot Study on the Effects of a Hydrogen Peroxide Mouthrinse on the Intraoral Viral Load of SARS-CoV-2, Clin Oral Investig
Hassandarvish, Tiong, Sazaly, Povidone Iodine Gargle and Mouthwash, Br Dent J, doi:10.1038/s41415-020-1794-1
He, Lau, Wu, Temporal Dynamics in Viral Shedding and Transmissibility of COVID-19, Nat Med, doi:10.1038/s41591-020-0869-5
Hiroi, Kubota-Koketsu, Sasaki, Infectivity Assay for Detection of SARS-CoV-2 in Samples from Patients With COVID-19, J Med Virol
Kampf, Todt, Pfaender, Persistence of Coronaviruses on Inanimate Surfaces and its Inactivation With Biocidal Agents, J Hosp Infect, doi:10.1016/j.jhin.2020.01.022
Kim, Chin, Kang, Clinical Course and Outcomes of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19, J Korean Med Sci, doi:10.3346/jkms.2020.35.e1
Koparal, Altuntas, Assessment of Mucociliary Clearance as an Indicator of Nasal Function in Patients With COVID-19: A Cross-Sectional Study, Eur Arch Otorhinolaryngol
Mason, Pathogenesis of COVID-19 From A Cell Biologic Perspective, Eur Respir J, doi:10.1183/13993003.00607-2020
Meister, Brüggemann, Todt, Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2, J Infect Dis
Mohamed, Baharom, Sulaiman, Early Viral Clearance Among Covid-19 Patients When Gargling With Povidone-Iodine and Assential Oils-A Clinical Trial, Int Med J
Moosavi, Aminishakib, Ansari, Antiviral Mouthwashes: Possible Benefit for COVID-19 With Evidence-Based Approach, J Oral Microbiol, doi:10.1080/20002297.2020.1794363
Peng, Xu, Li, Transmission Routes of 2019-nCoV and Controls in Dental Practice, Int J Oral Sci, doi:10.1038/s41368-020-0075-9
Platten, Hoffmann, Grosser, SARS-CoV-2, CT-Values, and Infectivity -Conclusions to be Drawn From Side Observations, Viruses, doi:10.3390/v13081459
Robinot, Hubert, De, SARS-CoV-2 Infection Induces the Dedifferentiation of Multiciliated Cells and Impairs Mucociliary Clearance, Nat Commun, doi:10.1038/s41467-021-24521-x
Sah, Fitzpatrick, Zimmer, Asymptomatic SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis, Proc Natl Acad Sci, doi:10.1073/pnas.2109229118
Satomura, Kitamura, Kawamura, Prevention of Upper Respiratory Tract Infections by Gargling: A Randomized Trial, Am J Prev Med, doi:10.1016/j.amepre.2005.06.013
Scola, Le, Andreani, Viral RNA Load as Determined by Cell Culture as a Management Tool for Discharge of SARS-CoV-2 Patients from Infectious Disease Wards, Eur J Clin Microbiol Infect Dis
Singh, Sharma, Singh, Nasopharyngeal Wash in Preventing and Treating Upper Respiratory Tract Infections: Could It Prevent COVID-19?, Lung India, doi:10.4103/lungindia.lungindia_241_20
Siordia, Epidemiology and Clinical Features of COVID-19: A Review of Current Literature, J Clin Virol, doi:10.1016/j.jcv.2020.104357
Stang, Robers, Schonert, The Performance of The SARS-CoV-2 RT-PCR Test as a Tool for Detecting SARS-CoV-2 Infection in the Population, J Infect
To, Tsang, Yip, Consistent Detection of 2019 Novel Coronavirus in Saliva, Clin Infect Dis, doi:10.1093/cid/ciaa149
Tsai, Wu, Possible Beneficial Role of Throat Gargling in the Coronavirus Disease Pandemic, Public Health, doi:10.1016/j.puhe.2020.05.055
Vergara-Buenaventura, Castro-Ruiz, Use of Mouthwashes Against COVID-19 in Dentistry, Br J Oral Maxillofac Surg, doi:10.1016/j.bjoms.2020.08.016
Wu, Wang, Kuo, An Update on Current Therapeutic Drugs Treating COVID-19, Curr Pharmacol Rep, doi:10.1007/s40495-020-00216-7
Yanti, Maulana, Sofiana, Nasal Rinse and Gargling as an Effort in Preventing COVID-19 Infection With Islamic Approach -A Literature Review, Bali Med J, doi:10.15562/bmj.v10i2.2397
Yoon, Yoon, Song, Clinical Significance of A High SARS-CoV-2 Viral Load in the Saliva, J Korean Med Sci, doi:10.3346/jkms.2020.35.e195
Zou, Ruan, Huang, SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients, N Engl J Med, doi:10.1056/NEJMc2001737
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