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Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers

Stufano et al., International Journal of Molecular Sciences, doi:10.3390/ijms24087445
Apr 2023  
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0 0.5 1 1.5 2+ PASC -19% Improvement Relative Risk Acetaminophen  Stufano et al.  LATE TREATMENT Is late treatment with acetaminophen beneficial for COVID-19? Retrospective 80 patients in Italy No significant difference in PASC c19early.org Stufano et al., Int. J. Molecular Scie.., Apr 2023 Favors acetaminophen Favors control
1st treatment shown to increase risk in November 2020
 
*, now known with p = 0.00000029 from 27 studies, but still recommended in 62 countries.
* From meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 80 mild COVID-19 patients in Italy, showing no significant difference in long COVID with acetaminophen use during infection.
Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
risk of PASC, 18.5% higher, RR 1.19, p = 0.62, treatment 11 of 23 (47.8%), control 23 of 57 (40.4%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Stufano et al., 18 Apr 2023, retrospective, Italy, peer-reviewed, 7 authors. Contact: annamaria.sardanelli@uniba.it (corresponding author).
This PaperAcetaminophenAll
Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers
Angela Stufano, Camilla Isgrò, Luigi Leonardo Palese, Paolo Caretta, Luigi De Maria, Piero Lovreglio, Anna Maria Sardanelli
International Journal of Molecular Sciences, doi:10.3390/ijms24087445
In addition to the acute symptoms after infection, patients and society are also being challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as a pivotal point in the pathophysiology of COVID-19, could potentially be also involved in the development of the post-COVID syndrome. The aim of the present study was to evaluate the relationship between changes in oxidative status and the persistence of long-COVID symptoms in workers with a previous mild COVID-19 infection. A cross-sectional study was conducted among 127 employees of an Italian university (80 with a previous COVID-19 infection, and 47 healthy subjects). The TBARS assay was used to detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production was measured by a d-ROMs kit. A significant difference in mean serum MDA values was found between previously infected subjects and healthy controls and (4.9 µm vs. 2.8 µm, respectively). Receiver-operating characteristic (ROC) curves showed high specificity and good sensibility (78.7% and 67.5%, respectively) for MDA serum levels. A random forest classifier identified the hematocrit value, MDA serum levels, and IgG titer against SARS-CoV-2 as features with the highest predictive value in distinguishing 34 long-COVID from 46 asymptomatic post-COVID subjects. Oxidative damage persists in subjects with previous COVID-19 infection, suggesting a possible role of oxidative stress mediators in the pathogenesis of long COVID.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflict of interest.
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Late treatment
is less effective
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