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0 0.5 1 1.5 2+ PASC -19% Improvement Relative Risk Stufano et al. Acetaminophen for COVID-19 LATE Is late treatment with acetaminophen beneficial for COVID-19? Retrospective 80 patients in Italy No significant difference in PASC Stufano et al., Int. J. Molecular Sciences, doi:10.3390/ijms24087445 Favors acetaminophen Favors control

Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers

Stufano et al., International Journal of Molecular Sciences, doi:10.3390/ijms24087445
Stufano et al., Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers, International Journal of Molecular Sciences, doi:10.3390/ijms24087445
Apr 2023   Source   PDF  
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Retrospective 80 mild COVID-19 patients in Italy, showing no significant difference in long COVID with acetaminophen use during infection. Acetaminophen is also known as paracetamol.
risk of PASC, 18.5% higher, RR 1.19, p = 0.62, treatment 11 of 23 (47.8%), control 23 of 57 (40.4%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Stufano et al., 18 Apr 2023, retrospective, Italy, peer-reviewed, 7 authors.
Contact: (corresponding author).
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Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers
Angela Stufano, Camilla Isgrò, Luigi Leonardo Palese, Paolo Caretta, Luigi De Maria, Piero Lovreglio, Anna Maria Sardanelli
International Journal of Molecular Sciences, doi:10.3390/ijms24087445
In addition to the acute symptoms after infection, patients and society are also being challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as a pivotal point in the pathophysiology of COVID-19, could potentially be also involved in the development of the post-COVID syndrome. The aim of the present study was to evaluate the relationship between changes in oxidative status and the persistence of long-COVID symptoms in workers with a previous mild COVID-19 infection. A cross-sectional study was conducted among 127 employees of an Italian university (80 with a previous COVID-19 infection, and 47 healthy subjects). The TBARS assay was used to detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production was measured by a d-ROMs kit. A significant difference in mean serum MDA values was found between previously infected subjects and healthy controls and (4.9 µm vs. 2.8 µm, respectively). Receiver-operating characteristic (ROC) curves showed high specificity and good sensibility (78.7% and 67.5%, respectively) for MDA serum levels. A random forest classifier identified the hematocrit value, MDA serum levels, and IgG titer against SARS-CoV-2 as features with the highest predictive value in distinguishing 34 long-COVID from 46 asymptomatic post-COVID subjects. Oxidative damage persists in subjects with previous COVID-19 infection, suggesting a possible role of oxidative stress mediators in the pathogenesis of long COVID.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflict of interest.
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Late treatment
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