Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: A systematic review and meta‐analysis

{ 'indexed': {'date-parts': [[2024, 8, 1]], 'date-time': '2024-08-01T05:06:19Z', 'timestamp': 1722488779796}, 'reference-count': 51, 'publisher': 'Wiley', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2023, 1, 8]], 'date-time': '2023-01-08T00:00:00Z', 'timestamp': 1673136000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 3]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Some proportions of populations, such as ' 'immunocompromised patients and organ transplant recipients might have inadequate immune ' 'responses to the vaccine for coronavirus disease 2019 (COVID‐19). For these groups of ' 'populations, administering monoclonal antibodies might offer some additional protection. This ' 'review sought to analyze the effectiveness and safety of tixagevimab‐cilgavimab (Evusheld) as ' 'pre‐exposure prophylaxis against COVID‐19. We used specific keywords to comprehensively ' 'search for potential studies on PubMed, Scopus, Europe PMC, and <jats:ext-link ' 'xmlns:xlink="http://www.w3.org/1999/xlink" ' 'xlink:href="http://ClinicalTrials.gov">ClinicalTrials.gov</jats:ext-link> sources until 3 ' 'September 2022. We collected all published articles that analyzed tixagevimab‐cilgavimab on ' 'the course of COVID‐19. Review Manager 5.4 was utilized for statistical analysis. Six studies ' 'were included. Our pooled analysis revealed that tixagevimab‐cilgavimab prophylaxis may ' 'decrease the rate of SARS‐CoV‐2 infection (OR: 0.24; 95% CI: 0.15–0.40, ' '<jats:italic>p</jats:italic>\xa0&lt;\xa00.00001, ' '<jats:italic>I</jats:italic><jats:sup><jats:italic>2</jats:italic></jats:sup>\xa0=\xa075%), ' 'lower COVID‐19 hospitalization rate (OR: 0.13; 95% CI: 0.07–0.24, ' '<jats:italic>p</jats:italic>\xa0&lt;\xa00.00001, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\xa0=\xa00%), decrease the severity risk ' '(OR: 0.13; 95% CI: 0.07–0.24, <jats:italic>p</jats:italic>\xa0&lt;\xa00.00001, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\xa0=\xa00%), and lower COVID‐19 deaths ' '(OR: 0.17; 95% CI: 0.03–0.99, <jats:italic>p</jats:italic>\xa0=\xa00.05, ' '<jats:italic>I</jats:italic><jats:sup>2</jats:sup>\xa0=\xa072%). In the included studies, no ' 'major adverse events were reported. This study proposes that tixagevimab‐cilgavimab was ' 'effective and safe for preventing COVID‐19. Tixagevimab‐cilgavimab may be offered to those ' 'who cannot be vaccinated or have inadequate immune response from the COVID‐19 vaccine to give ' 'additional protection.</jats:p>', 'DOI': '10.1002/rmv.2420', 'type': 'journal-article', 'created': {'date-parts': [[2023, 1, 9]], 'date-time': '2023-01-09T05:38:56Z', 'timestamp': 1673242736000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 22, 'title': 'Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: A ' 'systematic review and meta‐analysis', 'prefix': '10.1002', 'volume': '33', 'author': [ { 'given': 'Arto Yuwono', 'family': 'Soeroto', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Internal Medicine Division of Pulmonology and ' 'Critical Illness Padjadjaran University Bandung West Java ' 'Indonesia'}]}, { 'given': 'Theo Audi', 'family': 'Yanto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine Faculty of Medicine Pelita ' 'Harapan University Tangerang Indonesia'}]}, { 'ORCID': 'http://orcid.org/0000-0002-5219-9029', 'authenticated-orcid': False, 'given': 'Andree', 'family': 'Kurniawan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine Faculty of Medicine Pelita ' 'Harapan University Tangerang Indonesia'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1748-9776', 'authenticated-orcid': False, 'given': 'Timotius Ivan', 'family': 'Hariyanto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Pelita Harapan University Tangerang ' 'Indonesia'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 1, 8]]}, 'reference': [ { 'key': 'e_1_2_10_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jpsychires.2021.08.031'}, { 'key': 'e_1_2_10_3_1', 'unstructured': 'World Health Organization.Coronavirus Disease (COVID‐19): Situation ' 'Report;2022. 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