0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mockeliunas -134% 2.34 [1.54-3.52] cases 274 (n) 726 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Early treatment -134% 2.34 [1.54-3.52] 274 (n) 726 (n) 134% higher risk Paul 37% 0.63 [0.32-1.16] PASC 1,811 (all patients) LONG COVID Improvement, RR [CI] Treatment Control Montini -270% 3.70 [2.04-6.67] cases case control Akbar -82% 1.82 [1.47-2.27] cases 1,866 (n) 8,134 (n) Pavlidou -72% 1.72 [1.49-1.96] cases 3,345 (n) 1,852 (n) Tau​2​ = 0.24, I​2​ = 84.1%, p = 0.055 Prophylaxis -69% 1.69 [0.99-2.88] 5,211 (n) 9,986 (n) 69% higher risk All studies -81% 1.81 [1.20-2.75] 5,485 (n) 10,712 (n) 81% higher risk 5 smoking COVID-19 studies c19early.org March 2024 Tau​2​ = 0.17, I​2​ = 80.2%, p = 0.0051 Effect extraction pre-specified(most serious outcome) Favors no smoking Favors smoking
Jul 26
2024
Milad et al., Cannabis, doi:10.26828/cannabis/2024/000248 Dried Cannabis Use, Tobacco Smoking, and COVID-19 Infection: Findings from a Longitudinal Observational Cohort Study
Longitudinal observational cohort study of 1,343 community adults in Canada, showing increased risk of self-reported COVID-19 infection with dried cannabis use. Cannabis users were younger than the control group.
Mar 19
2024
Mockeliunas et al., Vaccines, doi:10.3390/vaccines12030329 Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic
134% more cases (p<0.0001). Retrospective 1,000 frontline healthcare workers in South Africa showing higher risk of COVID-19 for non-smokers.
Nov 9
2023
Pavlidou et al., Diseases, doi:10.3390/diseases11040165 Association of COVID-19 Infection with Sociodemographic, Anthropometric and Lifestyle Factors: A Cross-Sectional Study in an Older Adults’ Population Aged over 65 Years Old
72% more cases (p=0.02). Retrospective 5,197 Greek adults over 65. After adjustment for confounders, COVID-19 infection was independently associated with poor sleep, low physical activity, low Mediterranean diet adherence, living in urban areas, smoking, obesity,..
Nov 7
2023
Akbar et al., Nutrients, doi:10.3390/nu16071037 The Association between Lifestyle Factors and COVID-19: Findings from Qatar Biobank
82% more cases (p<0.0001). Retrospective 10,000 adults in Qatar, showing lower risk of COVID-19 cases with smoking. Authors do not analyze COVID-19 severity.
Feb 16
2023
Montini et al., Journal of Neurology, doi:10.1007/s00415-023-11618-0 Modifiable risk factors of COVID-19 in patients with multiple sclerosis: a single-centre case–control study
270% more cases (p<0.0001). Case control analysis with 149 multiple sclerosis patients and 292 matched controls in Italy, showing lower risk of COVID-19 cases with smoking.
Apr 13
2022
Paul et al., medRxiv, doi:10.1101/2022.04.12.22273792 Health behaviours the month prior to COVID-19 infection and the development of self-reported long COVID and specific long COVID symptoms: A longitudinal analysis of 1,811 UK adults
37% lower long COVID (p=0.14). Retrospective 1,811 COVID-19 patients in the UK, showing lower risk of self-reported long COVID with no smoking in the month before infection, not reaching statistical significance (p=0.14).
Oct 25
2021
Razjouyan et al., Nicotine & Tobacco Research, doi:10.1093/ntr/ntab223 Smoking Status and Factors associated with COVID-19 In-Hospital Mortality among US Veterans
3% lower mortality (p=0.8). Retrospective 10,074 hospitalized veterans with COVID-19 in the USA, showing higher risk of mortality for former smokers and no significant difference for current smokers.
Jun 23
2020
Hedenstierna et al., Nitric Oxide, doi:10.1016/j.niox.2020.06.005 Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19
Hypothesis that reduced incidence of COVID-19 cases for smokers in some studies is due to bursts of high concentrations of nitric oxide during smoking.
May 11
2020
Patanavanich et al., Nicotine & Tobacco Research, doi:10.1093/ntr/ntaa082 Smoking Is Associated With COVID-19 Progression: A Meta-analysis
Meta analysis showing higher risk of progression for smokers among people with COVID-19.