Analgesics
Antiandrogens
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lactoferrin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Peg.. Lambda
Quercetin
Remdesivir
Vitamins

Other
Feedback
Home
Top
Abstract
All acetaminophen studies
Meta analysis
 
Feedback
Home
c19early.org COVID-19 treatment researchAcetaminophenAcetaminophen (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  

AI-based disease risk score for community-acquired pneumonia hospitalization

Shakibfar et al., iScience, doi:10.1016/j.isci.2023.107027
Jul 2023  
  Twitter
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Pre-COVID model of community-acquired pneumonia (CAP) identifying acetaminophen as one of the top 10 predictors for hospitalization.
Authors claim that acetaminophen was not a biologically plausible predictor of CAP, hypothesizing that acetaminophen may be a proxy for other conditions that increase CAP risk, specifically chronic pain.
Although authors claim there is no biological plausibility, there are multiple potential mechanisms including:
- Glutathione depletion - acetaminophen metabolism relies on glutathione. Higher or chronic doses can deplete glutathione levels. Lower glutathione reduces antioxidant defenses and impairs immune cell function.
- Prostaglandin inhibition - acetaminophen inhibits prostaglandins like PGE2 that help regulate immune responses. Reduced prostaglandins could potentially alter immune regulation.
- Disruption of redox balance - in addition to glutathione, acetaminophen may disrupt the redox balance which can impair immune cell function.
- Glycine depletion - conjugating acetaminophen requires glycine. Depletion of glycine can reduce antioxidant production and have immunomodulatory effects.
- Microbiome alteration - acetaminophen exposure might alter the intestinal microbiota in ways that promote inflammation and reduce colonization resistance.
- Cell/tissue injury - even at normal doses, acetaminophen may cause low-grade cell or tissue damage that induces inflammatory and immune effects.
- Fever suppression - by reducing fever through effects on the hypothalamus, acetaminophen could potentially prolong infections. Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
Shakibfar et al., 31 Jul 2023, Denmark, peer-reviewed, 3 authors.
Contact: maurizio.sessa@sund.ku.dk.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperAcetaminophenAll
AI-based disease risk score for communityacquired pneumonia hospitalization
Saeed Shakibfar, Morten Andersen, Maurizio Sessa
doi:10.1016/j.isci
We developed a disease risk score for CAP hospitalization based on real-world data This tool can help to identify individuals requiring specific clinical management Further studies are needed to investigate the optimal use of our disease risk
Detailed methods are provided in the online version of this paper and include the following: SUPPLEMENTAL INFORMATION Supplemental information can be found online at https://doi.org/10.1016/j.isci.2023.107027. AUTHOR CONTRIBUTIONS S.S. wrote the original draft, conceptualized the study, and performed the data analysis. M.A. supervised the study, acquired the funding, and revised the manuscript. M.S. planned the study, performed the data analysis, wrote the original draft, and supervised the study. DECLARATION OF INTERESTS None. INCLUSION AND DIVERSITY We support inclusive, diverse, and equitable conduct of research. KEY RESOURCES TABLE RESOURCE AVAILABILITY Lead contact Further information and requests for data sources should be directed to and will be fulfilled by the lead contact, Maurizio Sessa (maurizio.sessa@sund.ku.dk). Material availability This study did not generate new unique reagents. Data and code availability d All data will be shared upon request to the lead contact. No standardized datatype data were generated in this study. d This study did not generate new code. d Any additional analysis information for this work is available by request to the lead contact. EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS The study does not need ethical approval and patient consent because Danish register-based cohort studies are exempted. Patient records/information before the analysis was pseudonymized. The University of Copenhagen and Statistics..
References
Adamuz, Viasus, Camprecio ´s-Rodrı ´guez, Can ˜avate-Jurado, Jime ´nez-Martı ´nez et al., A prospective cohort study of healthcare visits and rehospitalizations after discharge of patients with community-acquired pneumonia, Respirology
Aliberti, Dela Cruz, Amati, Sotgiu, Restrepo, Communityacquired pneumonia, Lancet
Andersen, Olivarius, Krasnik, The Danish national health service register, Scand. J. Public Health
Bischl, Lang, Kotthoff, Schiffner, Richter et al., Mlr: machine learning in R, J. Mach. Learn. Res
Branco, Torgo, Ribeiro, A survey of predictive modelling under imbalanced distributions, doi:10.48550/arXiv.1505.01658
Breiman, Random forests, Mach. Learn
Capelastegui, Espan ˜a Yandiola, Quintana, Bilbao, Diez et al., Predictors of short-term rehospitalization following discharge of patients hospitalized with community-acquired pneumonia, Chest
Cavallazzi, Ramirez, Community-acquired pneumonia in chronic obstructive pulmonary disease, Curr. Opin. Infect. Dis
Corrales-Medina, Alvarez, Weissfeld, Angus, Chirinos et al., Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease, JAMA
File, Jr, Community-acquired pneumonia, Lancet
Graffelman, Van Eeuwijk, Calibration of multivariate scatter plots for exploratory analysis of relations within and between sets of variables in genomic research, Biom. J
Hagengaard, Søgaard, Espersen, Sessa, Lund et al., Association between serum potassium levels and short-term mortality in patients with atrial fibrillation or flutter co-treated with diuretics and rate-or rhythm-controlling drugs, Eur. Heart J. Cardiovasc. Pharmacother
Helweg-Larsen, The Danish register of causes of death, Scand. J. Public Health
Jain, Self, Wunderink, Fakhran, Balk et al., Community-acquired pneumonia requiring hospitalization among US adults, N. Engl. J. Med
Jasti, Mortensen, Obrosky, Kapoor, Fine, Causes and risk factors for rehospitalization of patients hospitalized with communityacquired pneumonia, Clin. Infect. Dis
Kildemoes, Sørensen, Hallas, The Danish national prescription registry, Scand. J. Public Health
Klausen, Petersen, Lindhardt, Bandholm, Hendriksen et al., Outcomes in elderly Danish citizens admitted with community-acquired pneumonia. Regional differencties, in a public healthcare system, Respir. Med
Kuhn, Johnson, Applied Predictive Modeling
Larj, Bleecker, Therapeutic responses in asthma and COPD: corticosteroids, Chest
Letourneau, Issa, Baden, Pneumonia in the immunocompromised host, Curr. Opin. Pulm. Med
Luke, Harris, Network analysis in public health: history, methods, and applications
Lynge, Sandegaard, Rebolj, The Danish national patient register, Scand. J. Public Health
Mather, Fortunato, Ash, Davis, Kumar, Prediction of pneumonia 30-day readmissions: a singlecenter attempt to increase model performance, Respir. Care
Nembrini, Ko ¨nig, Wright, The revival of the Gini importance?, Bioinformatics
Neumann, Genze, Heider, EFS: an ensemble feature selection tool implemented as R-package and webapplication, BioData Min, doi:10.1186/s13040-017-0142-8
Pedersen, The Danish civil registration system, Scand. J. Public Health
Restrepo, Reyes, Pneumonia as a cardiovascular disease, Respirology
Sankaran, Mattana, Pollack, Bhat, Ahuja et al., Laboratory abnormalities in patients with bacterial pneumonia, Chest
Sessa, Mascolo, Andersen, Rosano, Rossi et al., Effect of chronic kidney diseases on mortality among digoxin users treated for non-valvular atrial fibrillation: a nationwide register-based retrospective cohort study, PLoS One
Sessa, Mascolo, Dalhoff, Andersen, The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine, Expert Opin. Drug Saf
Sessa, Mascolo, Mortensen, Andersen, Rosano et al., None
Sessa, Mascolo, Scavone, Perone, Di Giorgio et al., Comparison of long-term clinical implications of beta-blockade in patients with obstructive airway diseases exposed to beta-blockers with different b1-adrenoreceptor selectivity: an Italian Population-Based Cohort Study, Front. Pharmacol
Sessa, Rasmussen, Jensen, Kragholm, Torp-Pedersen et al., Metoprolol versus carvedilol in patients with heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and renal failure, Am. J. Cardiol
Shorr, Zilberberg, Reichley, Kan, Hoban et al., Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals, Clin. Infect. Dis
Stern, Skalsky, Avni, Carrara, Leibovici et al., Corticosteroids for pneumonia
Sun, Douiri, Gulliford, Applying machine learning algorithms to electronic health records predicted pneumonia after respiratory tract infection, J. Clin. Epidemiol
Søgaard, Nielsen, Schønheyder, Nørgaard, Thomsen, Nationwide trends in pneumonia hospitalization rates and mortality, Denmark 1997-2011, Respir. Med
Tang, Halm, Fine, Johnson, Anzueto et al., Predictors of rehospitalization after admission for pneumonia in the veterans affairs healthcare system, J. Hosp. Med
Ticona, Zaccone, Mcfarlane, Community-acquired pneumonia: a focused review, Am. J. Med. Case Rep
Torp-Pedersen, Relationship between heart failure, concurrent chronic obstructive pulmonary disease and beta-blocker use: a Danish nationwide cohort study, Eur. J. Heart Fail
Torres, Cilloniz, Niederman, Mene ´ndez, Chalmers et al., None, Pneumonia. Nat. Rev. Dis. Primers, doi:10.1038/s41572-021-00259-0
Torres, Peetermans, Viegi, Blasi, Risk factors for communityacquired pneumonia in adults in Europe: a literature review, Thorax
Yu, Liu, Efficient feature selection via analysis of relevance and redundancy, J. Mach. Learn. Res
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit