ROLE OF VITAMIN-D SUPPLEMENTATION IN COVID-19 PATIENTS
M Salman, S Zaman, U Aymun, S Khawar, I Khan, A Karim
Biological and Clinical Sciences Research Journal, doi:10.54112/bcsrj.v2023i1.322
COVID-19 has become a global pandemic and has affected millions of people worldwide. While there is still much to learn about the virus, it is clear that individuals with weakened immune systems and pre-existing health conditions are at higher risk of severe illness and death. The study's main objective is to find the role of Vitamin-D supplementation in COVID-19 patients. The study included 300 COVID-19 patients admitted to a tertiary care hospital between January 2021 and May 2021. Using computer-generated randomization, participants were randomly assigned to either the intervention group or the control group. The intervention group received a daily dose of 4000 IU of Vitamin D3 for 14 days, while the control group received standard care without Vitamin D supplementation. Per hospital guidelines, all patients received standard medical treatment for COVID-19, including oxygen therapy, antiviral therapy, and corticosteroids. The study showed that Vitamin D supplementation significantly reduced the time to clinical improvement in COVID-19 patients. The median time to clinical improvement was 7 days in the intervention group, compared to 9 days in the control group (p <0.001). The intervention group also had a significantly shorter length of hospital stay, with a median of 9 days, compared to 11 days in the control group (p <0.001). In conclusion, vitamin D supplementation's role in treating COVID-19 patients is an area of active research and has generated considerable interest in the scientific community. The results of the available studies suggest that vitamin D supplementation may have potential benefits in reducing the risk of severe COVID-19 and improving clinical outcomes.
Conflict of interest The authors declared absence of conflict of interest. [Citation Salman, M., Zaman, S., Aymun, U., Khawar, S., Khan, I., Karim, A.. ( 2023
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'abstract': '<jats:p>COVID-19 has become a global pandemic and has affected millions of people worldwide. '
'While there is still much to learn about the virus, it is clear that individuals with '
'weakened immune systems and pre-existing health conditions are at higher risk of severe '
"illness and death. The study's main objective is to find the role of Vitamin-D "
'supplementation in COVID-19 patients. The study included 300 COVID-19 patients admitted to a '
'tertiary care hospital between January 2021 and May 2021. Using computer-generated '
'randomization, participants were randomly assigned to either the intervention group or the '
'control group. The intervention group received a daily dose of 4000 IU of Vitamin D3 for 14 '
'days, while the control group received standard care without Vitamin D supplementation. Per '
'hospital guidelines, all patients received standard medical treatment for COVID-19, including '
'oxygen therapy, antiviral therapy, and corticosteroids. The study showed that Vitamin D '
'supplementation significantly reduced the time to clinical improvement in COVID-19 patients. '
'The median time to clinical improvement was 7 days in the intervention group, compared to 9 '
'days in the control group (p <0.001). The intervention group also had a significantly '
'shorter length of hospital stay, with a median of 9 days, compared to 11 days in the control '
"group (p <0.001). In conclusion, vitamin D supplementation's role in treating COVID-19 "
'patients is an area of active research and has generated considerable interest in the '
'scientific community. The results of the available studies suggest that vitamin D '
'supplementation may have potential benefits in reducing the risk of severe COVID-19 and '
'improving clinical outcomes.</jats:p>',
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