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Increased blood immune regulatory cells in severe COVID-19 with autoantibodies to type I interferons

Saheb Sharif-Askari et al., Scientific Reports, doi:10.1038/s41598-023-43675-w
Oct 2023  
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Cytometric analysis of the blood of 62 COVID-19 patients. Patients with severe COVID-19 had higher levels of regulatory T cells (Tregs) and regulatory B cells (Bregs) compared to patients with mild disease. Tregs and Bregs help control inflammation. High dose vitamin D treatment increased Tregs and Bregs and lowered inflammatory cytokines IL-6, IL-17, TNFα, IL-1β (statistically significant for IL-6 and IL-1β) in severe COVID-19 patients.
Saheb Sharif-Askari et al., 13 Oct 2023, United Arab Emirates, peer-reviewed, 10 authors. Contact: rhalwani@sharjah.ac.ae.
This PaperVitamin DAll
Increased blood immune regulatory cells in severe COVID-19 with autoantibodies to type I interferons
Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Shirin Hafezi, Hawra Ali Hussain Alsayed, Balachandar Selvakumar, Mariam Wed Abdelaziz Eladham, Bushra Mdkhana, Ola Salam Bayram, Mohamad-Hani Temsah, Rabih Halwani
Scientific Reports, doi:10.1038/s41598-023-43675-w
The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. While regulatory T (Treg) and B (Breg) cells, as the main elements of immune homeostasis, contribute to the control of hyperinflammation during COVID-19 infection, we hypothesized change in their levels in relation to disease severity and the presence of autoantibodies (auto-Abs) to type I IFNs. Cytometric analysis of blood of 62 COVID-19 patients with different severities revealed an increased proportion of conventional (cTreg; CD25 + FoxP3 + ) and unconventional (uTreg; CD25 -FoxP3 + ) Tregs, as well as the LAG3 + immune suppressive form of cTreg/ uTreg, in the blood of severe COVID-19 cases compared to the milder, non-hospitalized cases. The increase in blood levels of cTreg/uTreg, but not LAG3 + cTreg/uTreg subtypes, was even higher among patients with severe COVID-19 and auto-Abs to type I IFNs. Regarding Bregs, compared to the milder, non-hospitalized cases, the proportion of IL-35 + and IL-10 + Bregs was elevated in the blood of severe COVID-19 patients, and to a higher extent in those with auto-Abs to type I IFNs. Moreover, blood levels of cTreg, LAG3 + cTreg/uTreg, and IL-35 + and IL-10 + Breg subtypes were associated with lower blood levels of proinflammatory cytokines such as IL-6, IL-17, TNFα, and IL-1β. Interestingly, patients who were treated with either tocilizumab and/or a high dose of Vitamin D had higher blood levels of these regulatory cells and better control of the proinflammatory cytokines. These observations suggest that perturbations in the levels of immunomodulatory Tregs and Bregs occur in COVID-19, especially in the presence of auto-Abs to type I IFNs.
Author contributions Competing interests The authors declare no competing interests.
References
Alenazy, Abatacept enhances blood regulatory B cells of rheumatoid arthritis patients to a level that associates with disease remittance, Sci. Rep
Alenazy, Intranasal administration of abatacept enhances IL-35+ and IL-10+ producing Bregs in lung tissues of ovalbumin-sensitized asthmatic mice model, PLoS ONE
Alshammary, T-cell subsets and interleukin-10 levels are predictors of severity and mortality in COVID-19: A systematic review and meta-analysis, Front. Med
Antunes, Kassiotis, Suppression of innate immune pathology by regulatory T cells during influenza A virus infection of immunodeficient mice, J. Virol
Bastard, Autoantibodies against type I IFNs in patients with life-threatening COVID-19, Science
Bastard, Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Sci. Immunol
Chandran, Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial, Am. J. Transplant
Chauvineau-Grenier, Autoantibodies neutralizing type I interferons in 20% of COVID-19 deaths in a French Hospital, J. Clin. Immunol
Chen, Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3+Treg, Sci. Rep
D' Alessio, CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury, J. Clin. Investig
Dorward, Tissue-specific immunopathology in fatal COVID-19, Am. J. Respir. Crit. Care Med
Faul, Erdfelder, Buchner, Lang, Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses, Behav. Res. Methods
Fisher, The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review, PLoS ONE
Galván-Peña, Profound Treg perturbations correlate with COVID-19 severity, Proc. Natl. Acad. Sci
Gil-Manso, Multidimensional analysis of immune cells from COVID-19 patients identified cell subsets associated with the severity at hospital admission, PLoS Pathog
Inoue, Okamura, Komai, Yamamoto, Fujio, CD4+CD25-LAG3+ regulatory T cells in humoral immunity, Clin. Exp. Neuroimmunol
Kawano, Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression, J. Clin. Investig
Li, Clinical and pathological investigation of patients with severe COVID-19, JCI Insight
Mangodt, The role of Th17 and Treg responses in the pathogenesis of RSV infection, Pediatr. Res
Manry, The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies, Proc. Natl. Acad. Sci
Nam, Distinctive dynamics and functions of the CD4+CD25+FOXP3+ regulatory T cell population in patients with severe and mild COVID-19, J. Immunol
Neumann, Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19, Clin. Transl. Immunol
Okamura, CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2, Proc. Natl. Acad. Sci
Serdar, Cihan, Yücel, Serdar, Sample size, power and effect size revisited: Simplified and practical approaches in pre-clinical, clinical and laboratory studies, Biochem. Med
Sharif-Askari, Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection, Mol. Ther. Methods Clin. Dev
Shen, IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases, Nature
Stephen-Victor, Potential of regulatory T-cell-based therapies in the management of severe COVID-19, Eur. Respir. J
Sun, Chi, Tregs tango with killer cells in acute infection, Proc. Natl. Acad. Sci
Søndergaard, A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients, Proc. Natl. Acad. Sci
Uçaryılmaz, The role of CD8+ regulatory T cells and B cell subsets in patients with COVID-19, Turk. J. Med. Sci
Zhang, LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes, Sci. Immunol
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Med.'}], 'container-title': 'Scientific Reports', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.nature.com/articles/s41598-023-43675-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-023-43675-w', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-023-43675-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 10, 13]], 'date-time': '2023-10-13T10:22:17Z', 'timestamp': 1697192537000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41598-023-43675-w'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 10, 13]]}, 'references-count': 32, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 12]]}}, 'alternative-id': ['43675'], 'URL': 'http://dx.doi.org/10.1038/s41598-023-43675-w', 'relation': {}, 'ISSN': ['2045-2322'], 'subject': ['Multidisciplinary'], 'container-title-short': 'Sci Rep', 'published': {'date-parts': [[2023, 10, 13]]}, 'assertion': [ { 'value': '29 March 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '27 September 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '13 October 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'The authors declare no competing interests.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '17344'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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