Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All exercise studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchExerciseExercise (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Symp. case 9% Improvement Relative Risk Symp. case (b) 4% Exercise for COVID-19  Saadeh et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 587 patients in Sweden (March - June 2020) No significant difference in symptomatic cases c19early.org Saadeh et al., Aging Clinical and Expe.., Oct 2021 Favors exercise Favors inactivity

Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak

Saadeh et al., Aging Clinical and Experimental Research, doi:10.1007/s40520-021-02006-7
Oct 2021  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 904 patients in Sweden, showing higher risk of COVID-19-like symptoms with poor muscle strength. Risk was slightly higher for physical inactivity, without statistical significance.
risk of symptomatic case, 9.1% lower, OR 0.91, p = 0.71, high activity levels 362, low activity levels 225, adjusted per study, inverted to make OR<1 favor high activity levels, 2+ symptoms, Table 8, physically active vs. inactive, multivariable, RR approximated with OR.
risk of symptomatic case, 3.8% lower, OR 0.96, p = 0.85, high activity levels 362, low activity levels 225, adjusted per study, inverted to make OR<1 favor high activity levels, 1+ symptoms, Table 2, model 2, physically active vs. inactive, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saadeh et al., 30 Oct 2021, retrospective, Sweden, peer-reviewed, 6 authors, study period March 2020 - June 2020.
This PaperExerciseAll
Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak
Marguerita Saadeh, Amaia Calderón-Larrañaga, Davide Liborio Vetrano, Philip Von Rosen, Laura Fratiglioni, Anna-Karin Welmer
Aging Clinical and Experimental Research, doi:10.1007/s40520-021-02006-7
Background One's physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults. Methods We analyzed data from 904 individuals aged ≥ 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March-June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016-2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age. Results During the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1-2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged ≥ 80 years (OR 2.6; 95% CI 1.5-4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms. Conclusion Poor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.
Author contributions M Saadeh and A-K Welmer developed the study concept and design. M Saadeh performed the data analysis and drafted the manuscript. M Saadeh, A-K Welmer, A Calderón-Larrañaga, D L. Vetrano, P von Rosen, and L Fratiglioni interpreted the data. All authors provided critical revisions and approved the final version of the manuscript for submission. Funding Open access funding provided by Karolinska Institute. This work was supported by the funders of The Swedish National study on Aging and Care (SNAC): the Ministry of Health and Social Affairs, Sweden; the participating county councils and municipalities; and the Swedish Research Council. Specific grants were obtained from the Swedish Research Council (2017-06088); the Swedish Research Council for Health, Working Life and Welfare (2016-07175); Karolinska Institutet's Strategic Young Scholar Grants in Epidemiology or Biostatistics (SFO-EPI); and the Swedish National Graduate School on Ageing and Health (SWEAH). A specific grant was obtained for this study from the Swedish Research Council (2020-05931). The financial sponsors played no role in the design, execution, analysis and interpretation of data, or writing of the study. Declarations Conflict of interest The authors declare that they have no competing interests. Statement of human and animal rights Informed consent The principles of autonomy and integrity, the rule of consent and the demand for research. Consent for publication Not applicable. Open..
References
Adorni, Prinelli, Bianchi, Self-reported symptoms of SARS-CoV-2 infection in a nonhospitalized population in Italy: cross-sectional study of the EPICOVID19 Web-Based Survey, JMIR Public Health Surveill
Akınoğlu, Kocahan, Özkan, The relationship between peripheral muscle strength and respiratory function and respiratory muscle strength in athletes, J Exerc Rehabil
Bonanad, García-Blas, Tarazona-Santabalbina, The effect of age on mortality in patients with COVID-19: a metaanalysis with 611,583 subjects, J Am Med Dir Assoc
Calderón-Larrañaga, Vetrano, Onder, Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization, J Gerontol Ser A
Campbell, Turner, Debunking the myth of exerciseinduced immune suppression: redefining the impact of exercise on immunological health across the lifespan, Front Immunol
Carfì, Bernabei, Landi, Persistent symptoms in patients after acute COVID-19, JAMA
Cheval, Sieber, Maltagliati, Muscle strength is associated with COVID-19 hospitalization in adults 50 years of age and older, medRxiv
Clegg, Barber, Young, The Home-based Older People's Exercise (HOPE) trial: a pilot randomised controlled trial of a home-based exercise intervention for older people with frailty, Age Ageing
Cucinotta, Vanelli, WHO declares COVID-19 a pandemic, Acta Biomed
Dinh, Njemini, Onyema, Strength endurance training but not intensive strength training reduces senescence-prone T cells in peripheral blood in community-dwelling elderly women, J Gerontol Ser A
Dohrn, Gardiner, Winkler, Device-measured sedentary behavior and physical activity in older adults differ by demographic and health-related factors, Eur Rev Aging Phys Act
Edwardson, Winkler, Bodicoat, Considerations when using the activPAL monitor in field-based research with adult populations, J Sport Heal Sci
Ekram, Woods, Britt, The association between frailty and all-cause mortality in communitydwelling older individuals: an umbrella review, J Frailty Aging
Folkhälsomyndigheten, Groups at risk of serious illness
Fried, Tangen, Walston, Frailty in older adults: evidence for a phenotype, J Gerontol Ser A
Fritz, Lusardi, White paper: "walking speed: the sixth vital sign, J Geriatr Phys Ther
Hewitt, Carter, Vilches-Moraga, The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study, Lancet Public Heal
Huang, Lu, Huang, Obesity in patients with COVID-19: a systematic review and meta-analysis, Metabolism
Kapasi, Ouslander, Schnelle, Effects of an exercise intervention on immunologic parameters in frail elderly nursing home residents, J Gerontol Ser A
Kehler, Theou, The impact of physical activity and sedentary behaviors on frailty levels, Mech Ageing Dev
Kirwan, Mccullough, Butler, Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss, GeroScience
Kumar, Arora, Sharma, Is diabetes mellitus associated with mortality and severity of COVID-19? A metaanalysis, Diabetes Metab Syndr
Lavie, Ozemek, Carbone, Sedentary behavior, exercise, and cardiovascular health, Circ Res
Maltese, Corsonello, Rosa, Frailty and COVID-19: a systematic scoping review, J Clin Med
Marengoni, Zucchelli, Vetrano, Beyond chronological age: frailty and multimorbidity predict, J Gerontol A Biol Sci Med Sci
Nelke, Dziewas, Minnerup, Skeletal muscle as potential central link between sarcopenia and immune senescence, EBioMedicine
Nieman, Henson, Austin, Upper respiratory tract infection is reduced in physically fit and active adults, Br J Sports Med
Nieman, Wentz, The compelling link between physical activity and the body's defense system, J Sport Heal Sci
Pranata, Henrina, Lim, Clinical frailty scale and mortality in COVID-19: a systematic review and doseresponse meta-analysis: clinical frailty scale in COVID-19, Arch Gerontol Geriatr
Saadeh, Welmer, Dekhtyar, The role of psychological and social well-being on physical function trajectories in older adults, J Gerontol Ser A, doi:10.1093/gerona/glaa114
Simpson, Lowder, Spielmann, Exercise and the aging immune system, Ageing Res Rev
Studenski, Gait speed and survival in older adults, JAMA
Tudor-Locke, Han, Aguiar, How fast is fast enough? Walking cadence (steps/min) as a practical estimate of intensity in adults: a narrative review, Br J Sports Med
Unim, Palmieri, Noce, Prevalence of COVID-19-related symptoms by age group, Aging Clin Exp Res
Woods, Ceddia, Wolters, Effects of 6 months of moderate aerobic exercise training on immune function in the elderly, Mech Ageing Dev
Yates, Razieh, Zaccardi, Obesity, walking pace and risk of severe COVID-19: analysis of UK Biobank, medRxiv
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit