Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State
PhD Eli S Rosenberg, MD Elizabeth M Dufort, PhD Tomoko Udo, MS Larissa A Wilberschied, DO; Jessica Kumar, PhD James Tesoriero, PA Patti Weinberg, MPH James Kirkwood, MPH Alison Muse, MD Jack Dehovitz, MD Debra S Blog, MPH Brad Hutton, PhD David R Holtgrave, MD Howard A Zucker
JAMA, doi:10.1001/jama.2020.8630
IMPORTANCE Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients with coronavirus disease 2019 (COVID-19). However, there are limited data on efficacy and associated adverse events. OBJECTIVE To describe the association between use of hydroxychloroquine, with or without azithromycin, and clinical outcomes among hospital inpatients diagnosed with COVID-19.
DESIGN, SETTING, AND PARTICIPANTS Retrospective multicenter cohort study of patients from a random sample of all admitted patients with laboratory-confirmed COVID-19 in 25 hospitals, representing 88.2% of patients with COVID-19 in the New York metropolitan region. Eligible patients were admitted for at least 24 hours between March 15 and 28, 2020. Medications, preexisting conditions, clinical measures on admission, outcomes, and adverse events were abstracted from medical records. The date of final follow-up was April 24, 2020.
Abbreviations: COVID-19, coronavirus disease 2019; ICU, intensive care unit; IQR, interquartile range. a Receipt of intensive care may not have been in a traditional critical care unit. b Based on open-text and ICD-10 fields for cause of death. Causes are not mutually exclusive. c Denominator is the total patient-days in the hospital experienced by the group. d Not applicable (NA) because there was only 1 patient in this group still admitted at analysis.
ARTICLE INFORMATION
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