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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Hospitalization 26% Improvement Relative Risk Recovery, dyspnea 32% Recovery, fever 80% Recovery, body ache 87% Recovery, headache 49% Recovery, weakness and f.. 63% Recovery, chest pain 20% Recovery, cough 40% Vitamin A  Rohani et al.  EARLY TREATMENT  DB RCT Is early treatment with vitamin A beneficial for COVID-19? Double-blind RCT 180 patients in Iran (May - September 2020) Trial underpowered to detect differences in serious outcomes c19early.org Rohani et al., Eastern Mediterranean H.., Aug 2022 Favors vitamin A Favors control

Evaluation and comparison of the effect of vitamin A supplementation with standard therapies in the treatment of patients with COVID-19

Rohani et al., Eastern Mediterranean Health Journal, doi:10.26719/emhj.22.064, IRCT46974
Aug 2022  
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Vitamin A for COVID-19
39th treatment shown to reduce risk in June 2023
 
*, now known with p = 0.031 from 13 studies.
Lower risk for recovery and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
RCT 91 vitamin A and 91 control patients in Iran, showing improved recovery with treatment. All patients received HCQ. 25,000IU/day oral vitamin A for 10 days.
risk of hospitalization, 25.6% lower, RR 0.74, p = 0.63, treatment 8 of 89 (9.0%), control 11 of 91 (12.1%), NNT 32.
risk of no recovery, 31.8% lower, RR 0.68, p = 0.53, treatment 4 of 89 (4.5%), control 6 of 91 (6.6%), NNT 48, dyspnea.
risk of no recovery, 79.6% lower, RR 0.20, p = 0.03, treatment 2 of 89 (2.2%), control 10 of 91 (11.0%), NNT 11, fever.
risk of no recovery, 87.2% lower, RR 0.13, p = 0.01, treatment 1 of 89 (1.1%), control 8 of 91 (8.8%), NNT 13, body ache.
risk of no recovery, 48.9% lower, RR 0.51, p = 0.32, treatment 3 of 89 (3.4%), control 6 of 91 (6.6%), NNT 31, headache.
risk of no recovery, 62.8% lower, RR 0.37, p = 0.05, treatment 4 of 89 (4.5%), control 11 of 91 (12.1%), NNT 13, weakness and fatigue.
risk of no recovery, 20.5% lower, RR 0.80, p = 0.63, treatment 7 of 89 (7.9%), control 9 of 91 (9.9%), NNT 49, chest pain.
risk of no recovery, 40.4% lower, RR 0.60, p = 0.24, treatment 7 of 89 (7.9%), control 12 of 91 (13.2%), NNT 19, cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rohani et al., 18 Aug 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, mean age 39.4, 6 authors, study period 1 May, 2020 - 1 September, 2020, trial IRCT46974. Contact: karimymahmood@yahoo.com.
This PaperVitamin AAll
Evaluation and comparison of vitamin A supplementation with standard therapies in the treatment of patients with COVID-19
Mohamad R Rohani, Hasan Mozaffar, Mehdi Mesri, Mehdi Shokri, Daniel Delaney, Mahmood Karimy
Eastern Mediterranean Health Journal, doi:10.26719/emhj.22.064
Background: Incomplete data are presented to determine the role of vitamin A supplement therapy to improve outcomes in patients with coronavirus disease 2019 (COVID-19). Aims: We compared treatment effects between a groups that received vitamin A added to the standard COVID-19 treatment and a group that received the standard drug treatment alone. Methods: In this triple-blind controlled trial, the participants comprised 182 COVID-19 outpatients in Saveh city, Markazi Province, Islamic Republic of Iran, in 2020. Patients were randomly divided into experimental (n = 91) and control (n = 91) groups. Patients in the control group received the national standard treatment for COVID-19 (hydroxychloroquine), and those in the intervention group received 25 000 IU/d oral vitamin A for 10 days in addition to the standard treatment recommended by the national protocol. We evaluated the clinical symptoms, paraclinical criteria and hospitalization status before and 10 days after both interventions . Results: The treatment groups did not differ significantly in terms of clinical and paraclinical symptoms before the intervention, but clinical symptoms such as fever, body ache, weakness and fatigue, paraclinical symptoms, white blood cell count and C-reactive protein showed a significantly greater decrease in the experimental group 10 days post-intervention compared with the standard treatment alone (P < 0.05). Conclusion: Vitamin A supplement demonstrated efficacy in improving some clinical and paraclinical symptoms in patients with COVID-19. Future studies should evaluate vitamin A supplementation with a larger sample size and compare different dosages, especially in hospitalized patients.
References
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{ 'DOI': '10.26719/emhj.22.064', 'ISSN': ['1020-3397', '1687-1634'], 'URL': 'http://dx.doi.org/10.26719/emhj.22.064', 'abstract': '<jats:p>Background: Incomplete data are presented to determine the role of vitamin A ' 'supplement therapy to improve outcomes in patients with coronavirus disease 2019 (COVID-19). ' 'Aims: We compared treatment effects between a groups that received vitamin A added to the ' 'standard COVID-19 treatment and a group that received the standard drug treatment alone. ' 'Methods: In this triple-blind controlled trial, the participants comprised 182 COVID-19 ' 'outpatients in Saveh city, Markazi Province, Islamic Republic of Iran, in 2020. Patients were ' 'randomly divided into experimental (n = 91) and control (n = 91) groups. Patients in the ' 'control group received the national standard treatment for COVID-19 (hydroxychloroquine), and ' 'those in the intervention group received 25 000 IU/d oral vitamin A for 10 days in addition ' 'to the standard treatment recommended by the national protocol. We evaluated the clinical ' 'symptoms, paraclinical criteria and hospitalization status before and 10 days after both ' 'interventions. Results: The treatment groups did not differ significantly in terms of ' 'clinical and paraclinical symptoms before the intervention, but clinical symptoms such as ' 'fever, body ache, weakness and fatigue, paraclinical symptoms, white blood cell count and ' 'C-reactive protein showed a significantly greater decrease in the experimental group 10 days ' 'post-intervention compared with the standard treatment alone (P &lt; 0.05). Conclusion: ' 'Vitamin A supplement demonstrated efficacy in improving some clinical and paraclinical ' 'symptoms in patients with COVID-19. Future studies should evaluate vitamin A supplementation ' 'with a larger sample size and compare different dosages, especially in hospitalized ' 'patients.</jats:p>', 'author': [ {'affiliation': [], 'family': 'Rohani', 'given': 'Mohamad R.', 'sequence': 'first'}, {'affiliation': [], 'family': 'Mozaffar', 'given': 'Hasan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Mesri', 'given': 'Mehdi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Shokri', 'given': 'Mehdi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Delaney', 'given': 'Daniel', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Karimy', 'given': 'Mahmood', 'sequence': 'additional'}], 'container-title': 'Eastern Mediterranean Health Journal', 'container-title-short': 'East Mediterr Health J.', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2022, 8, 18]], 'date-time': '2022-08-18T11:51:40Z', 'timestamp': 1660823500000}, 'deposited': { 'date-parts': [[2022, 8, 18]], 'date-time': '2022-08-18T11:51:40Z', 'timestamp': 1660823500000}, 'indexed': {'date-parts': [[2022, 8, 18]], 'date-time': '2022-08-18T12:14:50Z', 'timestamp': 1660824890338}, 'is-referenced-by-count': 0, 'issued': {'date-parts': [[2022, 8, 18]]}, 'link': [ { 'URL': 'http://www.emro.who.int/in-press/research/evaluation-and-comparison-of-the-effect-of-vitamin-a-supplementation-with-standard-therapies-in-the-treatment-of-patients-with-covid-19.html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '11263', 'original-title': [], 'prefix': '10.26719', 'published': {'date-parts': [[2022, 8, 18]]}, 'published-online': {'date-parts': [[2022, 8, 18]]}, 'published-print': {'date-parts': [[2022, 8, 18]]}, 'publisher': 'World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO)', 'reference-count': 0, 'references-count': 0, 'relation': {}, 'resource': { 'primary': { 'URL': 'http://www.emro.who.int/in-press/research/evaluation-and-comparison-of-the-effect-of-vitamin-a-supplementation-with-standard-therapies-in-the-treatment-of-patients-with-covid-19.html'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['General Medicine'], 'subtitle': [], 'title': 'Evaluation and comparison of the effect of vitamin A supplementation with standard therapies in ' 'the treatment of patients with COVID-19', 'type': 'journal-article'}
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