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Micronutrient status (vitamins A and D) and its effect on the severity of the course of COVID-19 in children

Pavlyshyn et al., Неонатологія, хірургія та перинатальна медицина, doi:10.24061/2413-4260.XIV.1.51.2024.6

Apr 2024

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Vitamin A for COVID-19

39th treatment shown to reduce risk in June 2023

^*, now known with p = 0.031 from 13 studies.

Lower risk for recovery and cases.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

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Retrospective 112 pediatric COVID-19 patients and 23 healthy controls showing lower levels of vitamins A and D associated with more severe disease. Patients with moderate and severe COVID-19 had significantly lower vitamin A, vitamin D, and retinol-binding protein 4 (RBP4) levels compared to those with mild disease and healthy controls. Lower vitamin A and D levels were associated with higher levels of inflammatory markers such as CRP, leukocytes, and ESR.

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Study covers vitamin D and vitamin A.

risk of severe case, 60.6% lower, RR 0.39, p = 0.14, high vitamin A levels (≥200ng/ml) 9 of 99 (9.1%), low vitamin A levels (<200ng/ml) 3 of 13 (23.1%), NNT 7.1, (mild) deficiency vs. other.

risk of case, 84.3% lower, OR 0.16, p = 0.20, high vitamin A levels (≥200ng/ml) 99 of 112 (88.4%) cases, 23 of 23 (100.0%) controls, NNT 5.3, case control OR.

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Pavlyshyn et al., 5 Apr 2024, retrospective, Ukraine, peer-reviewed, 3 authors.

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