Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 93% Improvement Relative Risk Vitamin D for COVID-19  Pande et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 209 patients in India (October 2020 - October 2021) Lower severe cases with higher vitamin D levels (p<0.000001) c19early.org Pande et al., J. Communicable Diseases, Mar 2022 Favors vitamin D Favors control

Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective

Pande et al., Journal of Communicable Diseases, doi:10.24321/0019.5138.202227
Mar 2022  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 209 hospitalized patients in India, showing vitamin D deficiency associated with COVID-19 severity.
This is the 125th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of severe case, 93.4% lower, RR 0.07, p < 0.001, high D levels (≥20ng/ml) 7 of 116 (6.0%), low D levels (<20ng/ml) 85 of 93 (91.4%), NNT 1.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pande et al., 16 Mar 2022, retrospective, India, peer-reviewed, 7 authors, study period October 2020 - October 2021.
This PaperVitamin DAll
Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective
Durga Krishnan
Journal of Communicable Diseases, doi:10.24321/0019.5138.202227
Background: The recent COVID-19 pandemic has taken over the world in enormous proportions like none other in recent times. Vitamin D plays an essential role in the immune system and has proven to have importance in the context of many respiratory infections. This study aims to unveil the possible correlation between vitamin D levels and disease outcome and affirm the role of hypovitaminosis D as an independent risk factor for severity in COVID 19. Methods: We studied 209 RTPCR confirmed COVID 19 positive cases. Serum 25(OH) D levels were done at the time of admission. HRCT chest and inflammatory markers (serum ferritin, D dimer, IL6 and CRP) were estimated on admission and repeated on case-to-case basis. Results: Out of 209 patients studied, 44.49% had vitamin D deficiency, 24.40% had Vitamin D insufficiency, and 31.11% had normal Vitamin D levels. Vitamin D deficiency significantly increased with advancing age. The mean vitamin D level in our study is 27.47 ± 21.86. 27.8% had mild COVID-19 disease as evidenced by HRCT imaging, 21.1% showed moderate disease, and 51.2% showed severe COVID-19. The mean values of inflammatory markers in Vitamin D deficient patients were as follows : D dimer (3298.88 ± 2230.14), Serum Ferritin (530.88 ± 497.14) CRP (175.34 ± 87.27) IL6 (125.39 ± 275.72). Significant correlation of Vitamin D with C reactive protein (r = -0.18, p ≤ 0.05), D-Dimer (r = -0.42, p < 0.0001), and CT severity score (r = -0.24, p ≤ 0.0001) was noted. Conclusion: In our study, Vitamin D inversely proportional levels were inversely proportional to CRP, D-Dimer, and CT severity.
Conflict of Interest: None Sources of Funding: None
References
Carpagnano, Lecce, Quaranta, Zito, Buonamico et al., Special Issue -COVID-19 & Other Communicable Disease
Carr, Micronutrient status of COVID-19 patients: a critical consideration, Crit Care
Cascella, Rajnik, Aleem, Dulebohn, Napoli, Features, evaluation, and treatment of Coronavirus (COVID-19)
D'avolio, Avataneo, Manca, Cusato, Nicolò et al., 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients
Demir, Demir, Aygun, Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease, J Med Virol
Hunter, Jones, IL-6 as a keystone cytokine in health and disease, Nat Immunol
Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci Rep
Kishore, Grimes, Anderson, Bharti, Joseph et al., Recommendations for high vitamin D supplementation to help fight the COVID-19 pandemic and its inclusion in National COVID-19 management guidelines, Epidem Int
Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J Med Virol
Nimavat, Singh, Singh, Singh, Sinha, Vitamin D deficiency and COVID-19: acase-control study at a tertiary care hospital in India, Ann Med Surg (Lond)
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Ricci, Pagliuca, 'ascanio, Innammorato, Vitis et al., Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients, Respir Res
Saeed, Gaba, Shah, Helali, Raidullah et al., Correlation between chest CT severity scores and the clinical parameters of adult patients with COVID-19
Singh, Nimavat, Singh, Ahmad, Sinha, Prevalence of low level of vitamin D among COVID-19 patients and associated risk factors in India-ahospitalbased study, Int J Gen Med
Sunnetcioglu, Sunnetcioglu, Gurbuz, Bedirhanoglu, Erginoguz et al., Serum 25(OH)Ddeficiency and high D-dimer levels are associated with COVID-19 pneumonia, Clin Lab
Teshome, Adane, Girma, Mekonnen, The impact of vitamin D level on COVID-19 infection: systematic review and meta-analysis, Front Public Health
Vn, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest
Ye, Tang, Liao, Shaw, Deng et al., Does serum vitamin D level affect COVID-19 infection and its severity?A case-control study, J Am CollNutr
{ 'DOI': '10.24321/0019.5138.202227', 'ISSN': ['0019-5138'], 'URL': 'http://dx.doi.org/10.24321/0019.5138.202227', 'abstract': '<jats:p>Background: The recent COVID-19 pandemic has taken over the world in enormous ' 'proportions like none other in recent times. Vitamin D plays an essential role in the immune ' 'system and has proven to have importance in the context of many respiratory infections. This ' 'study aims to unveil the possible correlation between vitamin D levels and disease outcome ' 'and affirm the role of hypovitaminosis D as an independent risk factor for severity in COVID ' '19.Methods: We studied 209 RTPCR confirmed COVID 19 positive cases. Serum 25(OH) D levels ' 'were done at the time of admission. HRCT chest and inflammatory markers (serum ferritin, D ' 'dimer, IL6 and CRP) were estimated on admission and repeated on case-to-case basis.Results: ' 'Out of 209 patients studied, 44.49% had vitamin D deficiency, 24.40% had Vitamin D ' 'insufficiency, and 31.11% had normal Vitamin D levels. Vitamin D deficiency significantly ' 'increased with advancing age. The mean vitamin D level in our study is 27.47 ± 21.86. 27.8% ' 'had mild COVID-19 disease as evidenced by HRCT imaging, 21.1% showed moderate disease, and ' '51.2% showed severe COVID-19. The mean values of inflammatory markers in Vitamin Ddeficient ' 'patients were as follows: D dimer (3298.88 ± 2230.14), Serum Ferritin (530.88 ± 497.14) CRP ' '(175.34 ± 87.27) IL6 (125.39 ± 275.72). Significant correlation of Vitamin D with C reactive ' 'protein (r = -0.18, p ≤ 0.05), D-Dimer (r = -0.42, p &lt; 0.0001), and CT severity score (r = ' '-0.24, p ≤ 0.0001) was noted. Conclusion: In our study, Vitamin D inversely proportional ' 'levels were inversely proportional to CRP, D-Dimer, and CT severity.</jats:p>', 'author': [ {'affiliation': [], 'family': 'Krishnan', 'given': 'Durga', 'sequence': 'first'}, { 'affiliation': [], 'name': 'Professor, Department of General Medicine, Chettinad Hospital and Research ' 'Institute, Chennai, Tamil Nadu, India.', 'sequence': 'first'}], 'container-title': 'Journal of Communicable Diseases', 'container-title-short': 'JCD', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2022, 4, 16]], 'date-time': '2022-04-16T05:07:05Z', 'timestamp': 1650085625000}, 'deposited': { 'date-parts': [[2022, 4, 16]], 'date-time': '2022-04-16T05:07:06Z', 'timestamp': 1650085626000}, 'indexed': {'date-parts': [[2022, 4, 16]], 'date-time': '2022-04-16T05:41:38Z', 'timestamp': 1650087698485}, 'is-referenced-by-count': 0, 'issued': {'date-parts': [[2022, 3, 16]]}, 'member': '10422', 'original-title': [ 'Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome ' 'in Hospitalised COVID-19 Patients - An Indian Perspective'], 'page': '171-176', 'prefix': '10.24321', 'published': {'date-parts': [[2022, 3, 16]]}, 'published-online': {'date-parts': [[2022, 3, 16]]}, 'publisher': 'Advanced Research Publications', 'reference-count': 0, 'references-count': 0, 'relation': {}, 'resource': { 'primary': { 'URL': 'https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/814'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['Infectious Diseases'], 'subtitle': [], 'title': 'Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in ' 'Hospitalised COVID-19 Patients - An Indian Perspective', 'type': 'journal-article'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit