Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective
Pande et al.
, Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19..
, Journal of Communicable Diseases, doi:10.24321/0019.5138.202227
Retrospective 209 hospitalized patients in India, showing vitamin D deficiency associated with COVID-19 severity.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
risk of severe case, 93.4% lower, RR 0.07, p < 0.001, high D levels (≥20ng/ml) 7 of 116 (6.0%), low D levels (<20ng/ml) 85 of 93 (91.4%), NNT 1.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pande et al., 16 Mar 2022, retrospective, India, peer-reviewed, 7 authors, study period October 2020 - October 2021.
Abstract: Journal of Communicable Diseases
Special Issue - COVID-19 & Other Communicable Diseases, Pg. No. 171-176
Peer Reviewed & Open Access Journal
Vitamin D Levels and its Association with
Inflammatory Markers, Severity and
Outcome in Hospitalised COVID-19
Patients - An Indian Perspective
Rajat Pande1, K Mayilananthi2, V Vrinda3, Rehab Yasir Nainar4, Bharanidharan G5,
Ragalikhith K6, Durga Krishnan7
Postgraduate, 2,7Professor, 3Assistant Professor, 5Senior Resident, Department of General Medicine, Chettinad Hospital and
Research Institute, Chennai, Tamil Nadu, India.
I N F O
A B S T R A C T
Durga Krishnan, Department of General
Medicine, Chettinad Hospital and Research
Institute, Chennai, Tamil Nadu, India.
How to cite this article:
Pande R, Mayilananthi K, Vrinda V, Nainar
RY, Bharanidharan G, Ragalikhith K, Krishnan
D. Vitamin D Levels and its Association with
Inflammatory Markers, Severity and Outcome
in Hospitalised COVID-19 Patients - An Indian
Perspective. Special Issue - COVID-19 & Other
Communicable Disease. 2022;171-176.
Background: The recent COVID-19 pandemic has taken over the world
in enormous proportions like none other in recent times. Vitamin D
plays an essential role in the immune system and has proven to have
importance in the context of many respiratory infections. This study aims
to unveil the possible correlation between vitamin D levels and disease
outcome and affirm the role of hypovitaminosis D as an independent
risk factor for severity in COVID 19.
Date of Submission: 2021-10-29
Date of Acceptance: 2022-01-08
Methods: We studied 209 RTPCR confirmed COVID 19 positive cases.
Serum 25(OH) D levels were done at the time of admission. HRCT chest
and inflammatory markers (serum ferritin, D dimer, IL6 and CRP) were
estimated on admission and repeated on case-to-case basis.
Results: Out of 209 patients studied, 44.49% had vitamin D
deficiency, 24.40% had Vitamin D insufficiency, and 31.11% had
normal Vitamin D levels. Vitamin D deficiency significantly increased
with advancing age. The mean vitamin D level in our study is 27.47
± 21.86. 27.8% had mild COVID-19 disease as evidenced by HRCT
imaging, 21.1% showed moderate disease, and 51.2% showed severe
COVID-19. The mean values of inflammatory markers in Vitamin D
deficient patients were as follows: D dimer (3298.88 ± 2230.14), Serum
Ferritin (530.88 ± 497.14) CRP (175.34 ± 87.27) IL6 (125.39 ± 275.72).
Significant correlation of Vitamin D with C reactive protein (r = -0.18, p
≤ 0.05), D-Dimer (r = -0.42, p < 0.0001), and CT severity score (r = -0.24,
p ≤ 0.0001) was noted.
Conclusion: In our study, Vitamin D inversely proportional levels were
inversely proportional to CRP, D-Dimer, and CT severity.
Keywords: Vitamin D, COVID19, Inflammatory Markers
Journal of Communicable Diseases (P-ISSN: 0019-5138 & E-ISSN: 2581-351X)
Copyright (c) 2022: Author(s). Published by Advanced Research Publications
Pande R et al.
Special Issue - COVID-19 & Other Communicable Disease. 2022
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