Abstract: Journal of Communicable Diseases Special Issue - COVID-19 & Other Communicable Diseases, Pg. No. 171-176 Peer Reviewed & Open Access Journal Research Article Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective Rajat Pande1, K Mayilananthi2, V Vrinda3, Rehab Yasir Nainar4, Bharanidharan G5, Ragalikhith K6, Durga Krishnan7 Postgraduate, 2,7Professor, 3Assistant Professor, 5Senior Resident, Department of General Medicine, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India. DOI: https://doi.org/10.24321/0019.5138.202227 1,4,6 I N F O A B S T R A C T Corresponding Author: Durga Krishnan, Department of General Medicine, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India. E-mail Id: drdurga79@gmail.com Orcid Id: https://orcid.org/0000-0003-0249-5097 How to cite this article: Pande R, Mayilananthi K, Vrinda V, Nainar RY, Bharanidharan G, Ragalikhith K, Krishnan D. Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective. Special Issue - COVID-19 & Other Communicable Disease. 2022;171-176. Background: The recent COVID-19 pandemic has taken over the world in enormous proportions like none other in recent times. Vitamin D plays an essential role in the immune system and has proven to have importance in the context of many respiratory infections. This study aims to unveil the possible correlation between vitamin D levels and disease outcome and affirm the role of hypovitaminosis D as an independent risk factor for severity in COVID 19. Date of Submission: 2021-10-29 Date of Acceptance: 2022-01-08 Methods: We studied 209 RTPCR confirmed COVID 19 positive cases. Serum 25(OH) D levels were done at the time of admission. HRCT chest and inflammatory markers (serum ferritin, D dimer, IL6 and CRP) were estimated on admission and repeated on case-to-case basis. Results: Out of 209 patients studied, 44.49% had vitamin D deficiency, 24.40% had Vitamin D insufficiency, and 31.11% had normal Vitamin D levels. Vitamin D deficiency significantly increased with advancing age. The mean vitamin D level in our study is 27.47 ± 21.86. 27.8% had mild COVID-19 disease as evidenced by HRCT imaging, 21.1% showed moderate disease, and 51.2% showed severe COVID-19. The mean values of inflammatory markers in Vitamin D deficient patients were as follows: D dimer (3298.88 ± 2230.14), Serum Ferritin (530.88 ± 497.14) CRP (175.34 ± 87.27) IL6 (125.39 ± 275.72). Significant correlation of Vitamin D with C reactive protein (r = -0.18, p ≤ 0.05), D-Dimer (r = -0.42, p < 0.0001), and CT severity score (r = -0.24, p ≤ 0.0001) was noted. Conclusion: In our study, Vitamin D inversely proportional levels were inversely proportional to CRP, D-Dimer, and CT severity. Keywords: Vitamin D, COVID19, Inflammatory Markers Journal of Communicable Diseases (P-ISSN: 0019-5138 & E-ISSN: 2581-351X) Copyright (c) 2022: Author(s). Published by Advanced Research Publications Pande R et al. Special Issue - COVID-19 & Other Communicable Disease. 2022