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0 0.5 1 1.5 2+ Severe case 93% Improvement Relative Risk Vitamin D for COVID-19  Pande et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 209 patients in India (October 2020 - October 2021) Lower severe cases with higher vitamin D levels (p<0.000001) Pande et al., J. Communicable Diseases, Mar 2022 Favors vitamin D Favors control

Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective

Pande et al., Journal of Communicable Diseases, doi:10.24321/0019.5138.202227
Mar 2022  
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Retrospective 209 hospitalized patients in India, showing vitamin D deficiency associated with COVID-19 severity.
This is the 124th of 184 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 712 vigintillion). This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of severe case, 93.4% lower, RR 0.07, p < 0.001, high D levels (≥20ng/ml) 7 of 116 (6.0%), low D levels (<20ng/ml) 85 of 93 (91.4%), NNT 1.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pande et al., 16 Mar 2022, retrospective, India, peer-reviewed, 7 authors, study period October 2020 - October 2021.
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This PaperVitamin DAll
Vitamin D Levels and its Association with Inflammatory Markers, Severity and Outcome in Hospitalised COVID-19 Patients - An Indian Perspective
Durga Krishnan
Journal of Communicable Diseases, doi:10.24321/0019.5138.202227
Background: The recent COVID-19 pandemic has taken over the world in enormous proportions like none other in recent times. Vitamin D plays an essential role in the immune system and has proven to have importance in the context of many respiratory infections. This study aims to unveil the possible correlation between vitamin D levels and disease outcome and affirm the role of hypovitaminosis D as an independent risk factor for severity in COVID 19. Methods: We studied 209 RTPCR confirmed COVID 19 positive cases. Serum 25(OH) D levels were done at the time of admission. HRCT chest and inflammatory markers (serum ferritin, D dimer, IL6 and CRP) were estimated on admission and repeated on case-to-case basis. Results: Out of 209 patients studied, 44.49% had vitamin D deficiency, 24.40% had Vitamin D insufficiency, and 31.11% had normal Vitamin D levels. Vitamin D deficiency significantly increased with advancing age. The mean vitamin D level in our study is 27.47 ± 21.86. 27.8% had mild COVID-19 disease as evidenced by HRCT imaging, 21.1% showed moderate disease, and 51.2% showed severe COVID-19. The mean values of inflammatory markers in Vitamin D deficient patients were as follows : D dimer (3298.88 ± 2230.14), Serum Ferritin (530.88 ± 497.14) CRP (175.34 ± 87.27) IL6 (125.39 ± 275.72). Significant correlation of Vitamin D with C reactive protein (r = -0.18, p ≤ 0.05), D-Dimer (r = -0.42, p < 0.0001), and CT severity score (r = -0.24, p ≤ 0.0001) was noted. Conclusion: In our study, Vitamin D inversely proportional levels were inversely proportional to CRP, D-Dimer, and CT severity.
Conflict of Interest: None Sources of Funding: None
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