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Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19 infection?

Ozturk et al., Bratislava Medical Journal, doi:10.4149/BLL_2022_065
May 2022  
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Severe case 46% Improvement Relative Risk Vitamin D for COVID-19  Ozturk et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 300 patients in Turkey Lower severe cases with higher vitamin D levels (not stat. sig., p=0.1) Ozturk et al., Bratislava Medical J., May 2022 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Retrospective 300 hospitalized patients in Turkey with vitamin D levels measured with 6 months before admission, showing no significant difference in severity based on vitamin D deficiency.
This is the 135th of 199 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of severe case, 46.4% lower, RR 0.54, p = 0.10, high D levels (≥20ng/mL) 9 of 110 (8.2%), low D levels (<20ng/mL) 29 of 190 (15.3%), NNT 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ozturk et al., 16 May 2022, retrospective, Turkey, peer-reviewed, 6 authors. Contact:
This PaperVitamin DAll
Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19 infection?
MD Gulcan Ozturk, Berrin Zinnet Eraslan, Pinar Akpinar, Duygu Karamanlioglu silte, Feyza Ozkan unlu, Ilknur Aktas
Bratislava Medical Journal, doi:10.4149/bll_2022_065
OBJECTIVES: This study is aimed to determine the relationship between 25-OH vitamin D levels, infl ammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), c-reactive protein (CRP) levels and the disease severity of COVID-19 infection. BACKGROUND: Infl ammation plays a key role in the pathogenesis of COVID-19 while identifying the clinical course and prognosis. The effect of vitamin D defi ciency on contribution to infl ammation in COVID-19 is unclear. METHODS: Based on the classifi cation of the clinical course of COVID-19, the patients were divided into three groups, i.e., with mild (Group 1), moderate (Group 2) and severe/critical cases (Group 3). The 25-OH vitamin D values were defi ned as defi cient, insuffi cient or normal. RESULTS: There were no statistically signifi cant differences in the distribution rates of 25-OH vitamin D levels (p>0.05) between the groups. Infl ammatory parameters in Group 3 were statistically signifi cantly higher as compared to Groups1 and 2 (p < 0.05). Multivariate logistic regression analysis revealed that NLR was an independent predictor of disease severity. CONCLUSION: There is no relationship between the severity of COVID-19 infection and 25-OH vitamin D defi ciency. Infl ammatory parameters are associated with the disease severity, while NLR is an independent predictor of severe COVID-19. There was no correlation between 25-OH vitamin D and infl ammatory markers (Tab. 4, Fig. 1, Ref. 38).
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