Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19 infection?
Ozturk et al.
, Is there a relationship between vitamin D levels, inflammatory parameters, and clinical severity of COVID-19..
, Bratislava Medical Journal, doi:10.4149/BLL_2022_065
Retrospective 300 hospitalized patients in Turkey with vitamin D levels measured with 6 months before admission, showing no significant difference in severity based on vitamin D deficiency.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
risk of severe case, 46.4% lower, RR 0.54, p = 0.10, high D levels (≥20ng/mL) 9 of 110 (8.2%), low D levels (<20ng/mL) 29 of 190 (15.3%), NNT 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ozturk et al., 16 May 2022, retrospective, Turkey, peer-reviewed, 6 authors.
Abstract: DOI: 10.4149/BLL_2022_065
Bratisl Med J 2022; 123 (6)
421 – 427
Is there a relationship between vitamin D levels, inflammatory
parameters, and clinical severity of COVID-19 infection?
OZTURK Gulcan1, ERASLAN Berrin Zinnet2, AKPINAR Pinar1, KARAMANLIOGLU SILTE Duygu1,
OZKAN UNLU Feyza1, AKTAS Ilknur1
Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet
Education and Training Hospital, Istanbul, Turkey. firstname.lastname@example.org
OBJECTIVES: This study is aimed to determine the relationship between 25-OH vitamin D levels,
inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR),
c-reactive protein (CRP) levels and the disease severity of COVID-19 infection.
BACKGROUND: Inflammation plays a key role in the pathogenesis of COVID-19 while identifying the clinical
course and prognosis. The effect of vitamin D deficiency on contribution to inflammation in COVID-19 is
METHODS: Based on the classification of the clinical course of COVID-19, the patients were divided into
three groups, i.e., with mild (Group 1), moderate (Group 2) and severe/critical cases (Group 3). The 25-OH
vitamin D values were defined as deficient, insufficient or normal.
RESULTS: There were no statistically significant differences in the distribution rates of 25-OH vitamin D
levels (p>0.05) between the groups. Inflammatory parameters in Group 3 were statistically significantly higher
as compared to Groups1 and 2 (p < 0.05). Multivariate logistic regression analysis revealed that NLR was an
independent predictor of disease severity.
CONCLUSION: There is no relationship between the severity of COVID-19 infection and 25-OH vitamin D
deficiency. Inflammatory parameters are associated with the disease severity, while NLR is an independent
predictor of severe COVID-19. There was no correlation between 25-OH vitamin D and inflammatory markers
(Tab. 4, Fig. 1, Ref. 38). Text in PDF www.elis.sk
KEY WORDS: COVID-19 pandemic, severity of illness, inflammation, vitamin D.
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