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Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity

Ortatatli et al., Archives of Medical Research, doi:10.1016/j.arcmed.2023.02.002
Feb 2023  
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0 0.5 1 1.5 2+ Mortality, 20ng/mL 82% Improvement Relative Risk Mortality, 1ng/mL 74% Vitamin D for COVID-19  Ortatatli et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study in Turkey Lower mortality with higher vitamin D levels (not stat. sig., p=0.092) c19early.org Ortatatli et al., Archives of Medical .., Feb 2023 Favors vitamin D Favors control
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Analysis of 68 COVID-19 patients and 17 healthy controls, showing higher mortality with vitamin D deficiency, and with 1,25(OH)2D levels <1 ng/mL, statistically significant only for 1,25(OH)2D levels. Serum ACE2, 1,25(OH)2D, and ACE2 mRNA were correlated with severity, length of hospital stay, and mortality.
This is the 157th of 198 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 361,397 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 82.1% lower, RR 0.18, p = 0.09, cutoff 20ng/mL, inverted to make RR<1 favor high D levels (≥20ng/mL), 25(OH)D.
risk of death, 73.7% lower, RR 0.26, p = 0.04, cutoff 1ng/mL, inverted to make RR<1 favor high D levels (≥1ng/mL), 1,25(OH)2D.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ortatatli et al., 14 Feb 2023, prospective, Turkey, peer-reviewed, 9 authors. Contact: mortatatli@gmail.com.
This PaperVitamin DAll
Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity
Mesut Ortatatli, Tugba Fatsa, Tugba Fatsa, Deniz Dogan Mulazimoglu, Sema Oren, Cumhur Artuk, Tugrul Hosbul, Neslihan Kulahlıoglu, Levent Kenar
Archives of Medical Research, doi:10.1016/j.arcmed.2023.02.002
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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