Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity
Ortatatli et al.,
Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and..,
Archives of Medical Research, doi:10.1016/j.arcmed.2023.02.002
Analysis of 68 COVID-19 patients and 17 healthy controls, showing higher mortality with vitamin D deficiency, and with 1,25(OH)2D levels <1 ng/mL, statistically significant only for 1,25(OH)2D levels. Serum ACE2, 1,25(OH)2D, and ACE2 mRNA were correlated with severity, length of hospital stay, and mortality.
This study is excluded in the after exclusion results of meta
analysis:
unadjusted results with no group details.
risk of death, 82.1% lower, RR 0.18, p = 0.09, cutoff 20ng/mL, inverted to make RR<1 favor high D levels (≥20ng/mL), 25(OH)D.
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risk of death, 73.7% lower, RR 0.26, p = 0.04, cutoff 1ng/mL, inverted to make RR<1 favor high D levels (≥1ng/mL), 1,25(OH)2D.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Ortatatli et al., 14 Feb 2023, prospective, Turkey, peer-reviewed, 9 authors.
Contact:
mortatatli@gmail.com.
Abstract: NAME FOR TOP OF PAGES: Ortatatli, et al./Archives of Medical Research 54 (2023) x–x
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Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2
and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity
Mesut Ortatatli , Tugba Fatsa , Tugba Fatsa ,
Deniz Dogan Mulazimoglu , Sema Oren , Cumhur Artuk ,
Tugrul Hosbul , Neslihan Kulahlıoglu , Levent Kenar
PII:
DOI:
Reference:
S0188-4409(23)00015-2
https://doi.org/10.1016/j.arcmed.2023.02.002
ARCMED 2814
To appear in:
Archives of Medical Research
Received date:
Revised date:
Accepted date:
June 27, 2022
January 4, 2023
February 2, 2023
Please cite this article as: Mesut Ortatatli , Tugba Fatsa , Tugba Fatsa , Deniz Dogan Mulazimoglu ,
Sema Oren ,
Cumhur Artuk ,
Tugrul Hosbul ,
Neslihan Kulahlıoglu ,
Levent Kenar , Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARSCoV-2 Pathogenesis and COVID-19 Severity, Archives of Medical Research (2023), doi:
https://doi.org/10.1016/j.arcmed.2023.02.002
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© 2023 Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS).
Arch Med Res
22-00784
Archives of Medical Research 54 (2023) x–x
ORIGINAL ARTICLE
Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2
Pathogenesis and COVID-19 Severity
Mesut Ortatatli,a Tugba Fatsa,b Tugba Fatsa,b Deniz Dogan Mulazimoglu,c Sema Oren,b Cumhur
Artuk,d Tugrul Hosbul,e Neslihan Kulahlıoglu,a and Levent Kenara
a
Department of Medical CBRN Defence, University of Health Sciences, Etlik, Ankara, Turkey
b
Molecular Application and Research Unit of R and D Laboratory, University of Health Sciences,
Etlik, Ankara, Turkey
c
Department of Chest Diseases, Gulhane Faculty of Medicine, University of Health Sciences, Etlik,
Ankara, Turkey
d
Department of Infectious Diseases and Clinical Microbiology, Gulhane Faculty of Medicine,
University of Health Sciences, Etlik, Ankara, Turkey
e
Departmentof Medical Microbiology, Gulhane Faculty of Medicine, University of Health Sciences,
Etlik, Ankara, Turkey
Received for publication June 27, 2022; accepted February 2, 2023 (ARCME-D-225-00784).
Address reprint requets to: Mesut Ortatatli, Gülhane Eğitim ve Araştırma Hastanesi KBRN AD.
1
Arch Med Res
22-00784
Bşk.lığı, Ankara, Turkiye; Phone: (+00) (90) 312 304 3305; E-mail: mortatatli@gmail.com
NAME FOR TOP OF PAGES: Ortatatli, et al./Archives of Medical Research 54 (2023) x–x
Running title: Role of Vitamin D and ACE2 on COVID-19
Background. COVID-19, the 21st century pandemic disease caused by SARS-CoV-2, has shown a
wide clinical spectrum ranging from asymptomatic to deadly serious pneumonia.
Objective: In our study, the relationship between the pathogenesis and clinical severity of COVID-19
and vitamin D, ACE2, Furin and TMPRSS2 was investigated.
Methods. Serum 25(OH)D, 1,25(OH)2D and ACE2 protein were measured in 85 COVID-19 cases,
divided..
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