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0 0.5 1 1.5 2+ Mortality, 20ng/mL 82% Improvement Relative Risk Mortality, 1ng/mL 74% Vitamin D for COVID-19  Ortatatli et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study in Turkey Lower mortality with higher vitamin D levels (not stat. sig., p=0.092) Ortatatli et al., Archives of Medical .., Feb 2023 Favors vitamin D Favors control

Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity

Ortatatli et al., Archives of Medical Research, doi:10.1016/j.arcmed.2023.02.002
Feb 2023  
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Analysis of 68 COVID-19 patients and 17 healthy controls, showing higher mortality with vitamin D deficiency, and with 1,25(OH)2D levels <1 ng/mL, statistically significant only for 1,25(OH)2D levels. Serum ACE2, 1,25(OH)2D, and ACE2 mRNA were correlated with severity, length of hospital stay, and mortality.
This is the 156th of 184 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 712 vigintillion). This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 82.1% lower, RR 0.18, p = 0.09, cutoff 20ng/mL, inverted to make RR<1 favor high D levels (≥20ng/mL), 25(OH)D.
risk of death, 73.7% lower, RR 0.26, p = 0.04, cutoff 1ng/mL, inverted to make RR<1 favor high D levels (≥1ng/mL), 1,25(OH)2D.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ortatatli et al., 14 Feb 2023, prospective, Turkey, peer-reviewed, 9 authors.
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This PaperVitamin DAll
Potential Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity
Mesut Ortatatli, Tugba Fatsa, Tugba Fatsa, Deniz Dogan Mulazimoglu, Sema Oren, Cumhur Artuk, Tugrul Hosbul, Neslihan Kulahlıoglu, Levent Kenar
Archives of Medical Research, doi:10.1016/j.arcmed.2023.02.002
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