Abstract: VOLUME 39, NUMBER 1
ISSN 0189 - 160X
January 2022
WAJM
WEST AFRICAN JOURNAL OF MEDICINE
ORIGINALITY AND EXCELLENCE IN MEDICINE AND SURGERY
OFFICIAL PUBLICATION OF
THE WEST AFRICAN COLLEGE OF PHYSICIANS AND
WEST AFRICAN COLLEGE OF SURGEONS
www.wajmed.org
WEST AFRICAN JOURNAL OF MEDICINE
TABLE OF CONTENTS
GENERAL INFORMATION
INFORMATION FOR AUTHORS
EDITORIAL NOTES .............................................................................................................................................................................
1C
1F
1
ORIGINAL ARTICLES
Clinical Significance of Elevated Levels of Cardiac Troponin T in Patients with Chronic Kidney Disease at Lagos University
Teaching Hospital, Lagos .....................................................................................................................................................................
O. I. Ajie, E. C. Azinge, B. T. Bello, T. A. Oshodi, O. O. Soriyan, I. C. Udenze
Clinical Audit of Low Dose Prophylaxis Programme for Nigerian Children with Haemophilia .................................................
T. U. Nwagha, H. C. Okoye, C. E. Udo, S. Yuguda, K. I. Korubo, T. A. Adeyemo
Identifying the Clinical and Histological Risk Factors affecting Post-Biopsy Voiding Efficiency: An Observational Closed
Cohort Study .........................................................................................................................................................................................
M. A. Tolani, B. K. Hamza, M. Awaisu, A. O. Afolayan, A. T. Lawal, A. Bello
Maternal Outcomes of Eclampsia at the Lagos University Teaching Hospital: A Six-Year Retrospective Review ....................
A. A. Oluwole, A. O. Ugwu, A. P. Soibi-Harry, S. R. Garba, K. S. Okunade, C. C. Makwe, E. Owie, S.I. Omisakin, N.K. Ani-Ugwu,
I. T. Okafor, U. Ifezue, J. A. Olamijulo
Prevalence of Needle Stick and Sharps Injury and Hepatitis B Vaccination among Healthcare Workers in a South-East
Nigerian Tertiary Hospital ..................................................................................................................................................................
C. U. Onubogu, E. I. Nwaneli, C. G. Chigbo, M. C. Egbuniwe, R. O. Egeonu, S. N. Chukwurah, N. P. Maduekwe, I. Onyeyili,
C. P. UmobI, O. F. Emelumadu
Principles of Manual Tissue Processing in an Oral and Maxillofacial Pathology Laboratory in Lagos, Nigeria .....................
U. P. Egbunah, A. O. Akinshipo, O. F. Ajayi
Multiple Blood Transfusion may contribute to Abnormal Liver and Endocrine Functions in Adults with Sickle Cell Anaemia
O. A. Adeyeye, L. Salawu
Evaluation of Asymptomatic Malaria Antigenaemia and Parasitaemia in Human Immunodeficiency Virus-Infected
Children in Benin City, Nigeria .........................................................................................................................................................
M. O. Ibadin, N. Eghafona
Etiology and Clinical Evaluation of Patients with Bronchiectasis in a Tertiary Hospital in Nigeria ............................................
V. A. Umoh, D. D. Alasia, E. E. Akpan, U. Ekrikpo, E. E. Ekpe, M. E. Ekwere, E. Peters
Paediatric Cardiac Anaesthesia at the Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria: The Hurdles,
Struggles, and Successes .....................................................................................................................................................................
A...
DOI record:
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"abstract": "<jats:p>Background: Studies have demonstrated the role of sputum as a site of severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) transmission. However, there is limited literature on the virucidal efficacy of oral antiseptics against SARS-CoV-2 virus. This study investigated the virucidal efficacy of three oral-antiseptics compared to a placebo-control in the sputum of SARS-CoV-2 infected individuals.
\nMethodology: A pilot study of adults with SARS-CoV-2 positive results, as determined by reverse transcription-polymerase chain reaction (RT-PCR) of <7 days. The oral antiseptics investigated were: Hexetidine (0.1% w/v); Thymol (0.063% w/v) and H2O2(1.5%) compared to de-mineralized sterile water (Placebo-control). The primary outcome measure was the proportion of negative RT-PCR results at 15-mins, 30-mins, 1-hour, 2-hours and 4-hours After Oral antiseptics Interventions (AOI) compared to the placebo-control. Statistical analysis was done using STATA 15.0 software with p-values of <0.05 considered statistically significant.
\nResults: Data from a total of 66 participants that were RT-PCR SARS-CoV-2 positive at baseline (0-min) was analysed. At 15-mins AOI, the highest proportion of negativation from sputum samples was observed in the Hexedine group, with 69.2% of the baseline PCR positive cases converting to negative compared to 46.7% in the placebo-control group. In addition, H2O2 demonstrated efficacy at 2-hours AOI compared to placebo-control (62.5% vs 37.5% respectively) and other oral-antiseptics. Across all time-points, the oral-antiseptic groups compared to the placebo-control group, there was no statistically significant difference in the proportion of sputum samples which converted to a negative status (p>0.05).
\nConclusion: The findings in this study suggest there was no significant difference in the proportion of participants who converted to a negative sputum status across the treatment groups at various time points. Future studies could compare the cycle threshold (ct) viral titre values of sputum samples to determine quantitative differences.
\nAuthors
\nS A Ogun 1, O Erinoso 2, O O Aina 3, O I Ojo 2, O Adejumo 4, A Adeniran 2, A Bowale 4, C A Olaniyi 2, B M Adedoyin 5, B Mutiu 6, B Saka 6, O Oshinaike 2, W Arabambi 1, F Adejumo 4, O Shuaib 2, A O Salmon 2, H Abdur-Razzaq 7, O F Njokanma 2, O Ojini 8, O Ogboye 7, O Lajide 7, K O Wright 2, A Osibogun 8, A Abayomi 7</jats:p>",
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"title": "Efficacy of Hexetidine, Thymol and Hydrogen Peroxide-Containing Oral Antiseptics in Reducing Sars-Cov-2 Virus in the Oral Cavity: A Pilot Study",
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