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0 0.5 1 1.5 2+ Mortality 57% Improvement Relative Risk ICU admission -20% Vitamin D for COVID-19  Neves et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 115 patients in Brazil (July - December 2020) Lower mortality with higher vitamin D levels (p=0.046) c19early.org Neves et al., Clinical Nutrition ESPEN, Jun 2022 Favors vitamin D Favors control

Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19

Neves et al., Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2022.05.027
Jun 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 115 hospitalized patients in Brazil, showing lower mortality with higher vitamin D levels. Adjusted results are only provided for vitamin D as a continuous variable.
This is the 137th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
risk of death, 57.1% lower, RR 0.43, p = 0.046, high D levels (≥50nmol/L) 12 of 87 (13.8%), low D levels (<50nmol/L) 9 of 28 (32.1%), NNT 5.4.
risk of ICU admission, 19.5% higher, RR 1.20, p = 0.81, high D levels (≥50nmol/L) 26 of 87 (29.9%), low D levels (<50nmol/L) 7 of 28 (25.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Neves et al., 14 Jun 2022, retrospective, Brazil, peer-reviewed, mean age 62.1, 7 authors, study period July 2020 - December 2020. Contact: fabioneves@ufscar.br.
This PaperVitamin DAll
Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19
Fabio Fernandes Neves, Henrique Pott-Junior, Sigrid De Sousa Santos, Marcia Regina Cominetti, Caio Cesar De Melo Freire, Anderson Ferreira Da Cunha, Alceu Afonso Jordão Júnior
Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2022.05.027
Background & aims: Several studies have shown conflicting results for the relationship between vitamin D deficiency and COVID-19 outcomes. Here, we aimed to evaluate whether plasma 25(OH)D levels predict mortality in adults admitted with COVID-19, considering potential confounders. Methods: We conducted a retrospective cohort study that included 115 adults (age 62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Subjects were classified into two groups according to their plasma levels of 25(OH)D: sufficiency (50 nmol/L) and the deficiency (<50 nmol/L). The diagnosis of COVID-19 was performed using real-time polymerase chain reaction (qPCR). In addition, direct competitive chemiluminescence immunoassay assessed serum 25(OH)D levels. Results: The all-cause 30-day mortality was 13.8% (95% CI: 6.5%e21%) in the group of patients with sufficient plasma 25(OH)D levels and 32.1% (95% CI: 14.8%e49.4%) among those with deficient plasma 25(OH)D levels. Cox regression showed that plasma 25(OH)D levels remained a significant predictor of mortality even after adjusting for the covariates sex, age, length of the delay between symptom onset and hospitalization, and disease severity (HR ¼ 0.98, 95% CI: 0.96e1.00; p ¼ 0.02). Conclusion: Vitamin D deficiency predicts higher mortality risk in adults with COVID-19.
Author contributions Conceptualization, F.F.N. and H.P-J.; data curation, F.F.N., H.P-J. and S.S.S; formal analysis, F.F.N. and H.P-J.; funding acquisition, F.F.N.; investigation, F.F.N., H.P-J. and S.S.S; methodology, F.F.N., H.P-J., C.C.M.F, A.F.C. and A.A.J-J; resources, M.R.C., C.C.M.F, A.F.C. and A.A.J-J; software, H.P-J.; supervision, F.F.N. and H.P-J.; writing original draft, F.F.N. and H.P-J.; final approval: all authors. Declaration of competing interest The authors declare no conflicts of interest. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi.org/10.1016/j.clnesp.2022.05.027.
References
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