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All Studies   Meta Analysis    Recent:   

In vivo efficacy of 2% povidone iodine, chlorhexidine gluconate, and herbal extract mouthwash on SARS-CoV-2 viral load in saliva: A randomized clinical trial

Nazrine et al., Journal of Indian Society of Periodontology, doi:10.4103/jisp.jisp_469_22
Dec 2023  
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45th treatment shown to reduce risk in January 2024
 
*, now with p = 0.00000000062 from 3 studies.
Lower risk for progression, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Randomized trial of 30 COVID-19 patients in India, comparing povidone-iodine (PVP-I), chlorhexidine gluconate (CHX), and herbal extract mouthwash for reducing SARS-CoV-2 viral load in saliva after a 30 second rinse. All treatments showed an increase in PCR cycle threshold values at 30 minutes, suggesting reduced viral load, however the difference was only statistically significant for PVP-I.
Study covers chlorhexidine and povidone-iodine.
Nazrine et al., 31 Dec 2023, prospective, India, peer-reviewed, 4 authors, study period December 2021 - February 2022.
This PaperChlorhexidineAll
In vivo efficacy of 2% povidone iodine, chlorhexidine gluconate, and herbal extract mouthwash on SARS-CoV-2 viral load in saliva: A randomized clinical trial
Dr Sayana Nazrine, Ritesh Kulal, B M Shivaprasad, Nimmi Janardhanan
Journal of Indian Society of Periodontology, doi:10.4103/jisp.jisp_469_22
Background: One of the major techniques to reduce the transmission rate of COVID-19 would be to decrease the viral titers of SARS-CoV-2 in the saliva of infected patients and it is particularly useful in a dental setting. The present study evaluated the change in salivary viral load of COVID-19 patients using povidone iodine (PI), chlorhexidine (CHX), and an herbal extract (RightSure ® ) oral antiviral herbal mouthwash (HM) at clinically recommended duration and concentrations. Materials and Methods: Thirty individuals with SARS-CoV-2 were randomly allocated to three groups: (1) Group 1, PI mouthwash; (2) Group 2, CHX mouthwash; and (3) Group 3, HM mouthwash. A baseline salivary throat sample was collected from all the participants who were later instructed to rinse with their respective mouthwash for 30 s. A second salivary sample was collected 30 min after rinsing. The SARS-CoV-2 viral load was analyzed using real-time reverse-transcription polymerase chain reaction wherein the cyclic threshold (Ct) values were evaluated. Results: Independent t-test analysis reported a statistically significant difference concerning the PI group (before-after comparison) (P < 0.05). The rest of the two study groups failed to report any significant difference in the nucleocapsid gene and open reading frame 1a gene levels. Conclusion: While all three types of mouthwash increased the Ct values, a statistically significant difference was observed with PI mouthwash, indicating that it might potentially reduce the spread of the SARS-CoV-2 virus, especially via aerosol but further studies with larger sample size and longer follow-up periods are required to investigate this relationship.
Conflicts of interest There are no conflicts of interest.
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'21', 'author': 'Serlahwaty', 'year': '2021', 'journal-title': 'Pharm Educ'}], 'container-title': 'Journal of Indian Society of Periodontology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://journals.lww.com/10.4103/jisp.jisp_469_22', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 1, 26]], 'date-time': '2024-01-26T14:04:50Z', 'timestamp': 1706277890000}, 'score': 1, 'resource': {'primary': {'URL': 'https://journals.lww.com/10.4103/jisp.jisp_469_22'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023]]}, 'references-count': 31, 'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2023]]}}, 'URL': 'http://dx.doi.org/10.4103/jisp.jisp_469_22', 'relation': {}, 'ISSN': ['0972-124X', '0975-1580'], 'subject': ['Periodontics'], 'published': {'date-parts': [[2023]]}}
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