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Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

Naushin et al., eLife, doi:10.7554/eLife.66537
Apr 2021  
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Seropositive 40% Improvement Relative Risk Diet for COVID-19  Naushin et al.  Prophylaxis Is a healthy diet beneficial for COVID-19? Retrospective study in India Lower seropositivity with healthier diets (p<0.000001) c19early.org Naushin et al., eLife, April 2021 Favorshealthy diet Favorscontrol 0 0.5 1 1.5 2+
Diet for COVID-19
23rd treatment shown to reduce risk in June 2021, now with p < 0.00000000001 from 28 studies.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 104 treatments. c19early.org
Retrospective 10,427 volunteers in India, 1,058 anti-nucleocapsid antibody positive, showing lower risk of seropositivity with a vegetarian diet.
risk of seropositive, 40.1% lower, OR 0.60, p < 0.001, inverted to make OR<1 favor higher quality diet, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Naushin et al., 20 Apr 2021, retrospective, India, peer-reviewed, survey, 136 authors. Contact: ddash@igib.res.in, shantanus@igib.res.in.
This PaperDietAll
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2
Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum, Akash Kumar Bhaskar, Shalini Pradhan, Satyartha Prakash, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Giriraj Ratan Chandak, Amit Lahiri, Susanta Kar, Shrikant Ramesh Mulay, Madhav Nilakanth Mugale, Mrigank Srivastava, Shaziya Khan, Anjali Srivastava, Bhawana Tomar, Murugan Veerapandian, Ganesh Venkatachalam, Selvamani Raja Vijayakumar, Ajay Agarwal, Dinesh Gupta, Prakash M Halami, Muthukumar Serva Peddha, Gopinath M Sundaram, Ravindra P Veeranna, Anirban Pal, Vinay Kumar Agarwal, Anil Ku Maurya, Ranvijay Kumar Singh, Ashok Kumar Raman, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Subramanian Venkatesan, Harish Kumar Sardana, Anamika Kothari, Rishabh Jain, Anupama Thakur, Devendra Singh Parihar, Anas Saifi, Jasleen Kaur, Virendra Kumar, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Praveen Singh, Rahul Chakraborty, Gaura Chaturvedi, Pinreddy Karunakar, Rohit Yadav, Sunanda Singhmar, Dayanidhi Singh, Sharmistha Sarkar, Purbasha Bhattacharya, Sundaram Acharya, Vandana Singh, Shweta Verma, Drishti Soni, Surabhi Seth, Sakshi Vashisht, Sarita Thakran, Firdaus Fatima, Akash Pratap Singh, Akanksha Sharma, Babita Sharma, Manikandan Subramanian, Yogendra S Padwad, Vipin Hallan, Vikram Patial, Damanpreet Singh, Narendra Vijay Tripude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Jit Sarkar, Sistla Ramakrishna, Balthu Narender Kumar, Kiran A Kumar, Sumit G Gandhi, Piyush Singh Jamwal, Rekha Chouhan, Vijay Lakshmi Jamwal, Nitika Kapoor, Debashish Ghosh, Ghanshyam Thakkar, Umakanta Subudhi, Pradip Sen, Saumya Ray Chaudhury, Rashmi Kumar, Pawan Gupta, Amit Tuli, Deepak Sharma, Rajesh P Ringe, Mahesh Kulkarni, Dhansekaran Shanmugam, Mahesh S Dharne, Sayed G Dastager, Rakesh Joshi, Amita P Patil, Sachin N Mahajan, Abujunaid Habib Khan, Vasudev Wagh, Rakesh Kumar Yadav, Ajinkya Khilari, Mayuri Bhadange, Arvindkumar H Chaurasiya, Shabda E Kulsange, Krishna Khairnar, Shilpa Paranjape, Jatin Kalita, Narahari G Sastry, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, Ravi Kumar Sahu, Elapavalooru Vssk Babu, Rajeev Sukumaran, Aiswarya R Nair, Prajeesh Kooloth Valappil, Anoop Puthiyamadam, Adarsh Velayudhanpillai, Kalpana Chodankar, Samir Damare, Yennapu Madhavi, Ved Varun Aggarwal, Sumit Dahiya, Anurag Agrawal, Debasis Dash, Shantanu Sengupta
eLife, doi:10.7554/elife.66537
To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were highexposure work (odds ratio,
Additional files Supplementary files . Supplementary file 1. Male:female distribution among asymptomatic and symptomatic seropositive individuals. . Supplementary file 2. Frequency of symptoms in symptomatic seropositive individuals. . Supplementary file 3. Distribution for blood group type in our cohort against national average and positivity among different blood groups. OR: odds ratio. . Transparent reporting form
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