Angiotensin Converting Enzyme 2 is a molecular decoy for targeted photodynamic SARS-CoV-2 inactivation

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Ther.", "key": "10.1016/j.ijbiomac.2025.146128_bb0005", "volume": "34", "year": "2021" }, { "DOI": "10.3390/biomedicines9101434", "article-title": "Plant alkaloids inhibit membrane fusion mediated by calcium and fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 fusion peptides", "author": "Shekunov", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "Biomedicines", "key": "10.1016/j.ijbiomac.2025.146128_bb0010", "volume": "9", "year": "2021" }, { "DOI": "10.3390/antibiotics9060320", "article-title": "Antimicrobial photodynamic therapy in the control of COVID-19", "author": "Almeida", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "Antibiotics", "key": "10.1016/j.ijbiomac.2025.146128_bb0015", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.pdpdt.2021.102221", "article-title": "A systematic review of photodynamic therapy as an antiviral treatment: potential guidance for dealing with SARS-CoV-2", "author": "Conrado", "doi-asserted-by": "crossref", "journal-title": "Photodiagnosis Photodyn. Ther.", "key": "10.1016/j.ijbiomac.2025.146128_bb0020", "volume": "34", "year": "2021" }, { "DOI": "10.1016/j.dyepig.2021.109813", "article-title": "Anti-infective dyes in the time of COVID", "author": "Wainwright", "doi-asserted-by": "crossref", "journal-title": "Dyes Pigments", "key": "10.1016/j.ijbiomac.2025.146128_bb0025", "volume": "196", "year": "2021" }, { "DOI": "10.1016/j.pdpdt.2020.102112", "article-title": "Antiviral photodynamic therapy: inactivation and inhibition of SARS-CoV-2 in vitro using methylene blue and Radachlorin", "author": "Svyatchenko", "doi-asserted-by": "crossref", "journal-title": "Photodiagnosis Photodyn. Ther.", "key": "10.1016/j.ijbiomac.2025.146128_bb0030", "volume": "33", "year": "2021" }, { "DOI": "10.1016/j.pdpdt.2021.102642", "article-title": "Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infection", "author": "Arentz", "doi-asserted-by": "crossref", "journal-title": "Photodiagnosis Photodyn. Ther.", "key": "10.1016/j.ijbiomac.2025.146128_bb0035", "volume": "37", "year": "2022" }, { "DOI": "10.1007/s43630-022-00202-6", "article-title": "Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation", "author": "Lobo", "doi-asserted-by": "crossref", "first-page": "1101", "issue": "6", "journal-title": "Photochem. Photobiol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0040", "volume": "21", "year": "2022" }, { "DOI": "10.3390/v14061301", "article-title": "Photodynamic inactivation of SARS-CoV-2 infectivity and antiviral treatment effects in vitro", "author": "Ziganshyna", "doi-asserted-by": "crossref", "first-page": "1301", "issue": "6", "journal-title": "Viruses", "key": "10.1016/j.ijbiomac.2025.146128_bb0045", "volume": "14", "year": "2022" }, { "DOI": "10.3390/v13040643", "article-title": "The photosensitizer Octakis(cholinyl)zinc phthalocyanine with ability to bind to a model spike protein leads to a loss of SARS-CoV-2 infectivity in vitro when exposed to far-red LED", "author": "Sharshov", "doi-asserted-by": "crossref", "first-page": "643", "issue": "4", "journal-title": "Viruses", "key": "10.1016/j.ijbiomac.2025.146128_bb0050", "volume": "13", "year": "2021" }, { "DOI": "10.1021/acsami.1c22439", "article-title": "The interaction of Hypericin with SARS-CoV-2 reveals a multimodal antiviral activity", "author": "Delcanale", "doi-asserted-by": "crossref", "first-page": "14025", "issue": "12", "journal-title": "ACS Appl. Mater. Interfaces", "key": "10.1016/j.ijbiomac.2025.146128_bb0055", "volume": "14", "year": "2022" }, { "DOI": "10.3390/pharmaceutics14112364", "article-title": "Potent Virucidal activity in vitro of photodynamic therapy with hypericum extract as photosensitizer and white light against human coronavirus HCoV-229E", "author": "Praena", "doi-asserted-by": "crossref", "first-page": "2364", "issue": "11", "journal-title": "Pharmaceutics", "key": "10.1016/j.ijbiomac.2025.146128_bb0060", "volume": "14", "year": "2022" }, { "DOI": "10.3390/ph17010034", "article-title": "Photodynamic action of curcumin and methylene blue against bacteria and SARS-CoV-2–a review", "author": "Law", "doi-asserted-by": "crossref", "first-page": "34", "issue": "1", "journal-title": "Pharmaceuticals", "key": "10.1016/j.ijbiomac.2025.146128_bb0065", "volume": "17", "year": "2024" }, { "DOI": "10.3390/ijms25168724", "article-title": "Insights on the mechanical properties of SARS-CoV-2 particles and the effects of the photosensitizer hypericin", "author": "Mariangeli", "doi-asserted-by": "crossref", "first-page": "8724", "issue": "16", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0070", "volume": "25", "year": "2024" }, { "DOI": "10.3389/fcimb.2023.1110467", "article-title": "Photodynamic nasal SARS-CoV-2 decolonization shortens infectivity and influences specific T-cell responses", "author": "Fernandez-Montero", "doi-asserted-by": "crossref", "journal-title": "Front. Cell. Infect. Microbiol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0075", "volume": "13", "year": "2023" }, { "DOI": "10.1038/s41598-022-18513-0", "article-title": "Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2", "author": "Pires", "doi-asserted-by": "crossref", "first-page": "14438", "issue": "1", "journal-title": "Sci. Rep.", "key": "10.1016/j.ijbiomac.2025.146128_bb0080", "volume": "12", "year": "2022" }, { "DOI": "10.1016/j.jhin.2014.06.017", "article-title": "Nasal photodisinfection and chlorhexidine wipes decrease surgical site infections: a historical control study and propensity analysis", "author": "Bryce", "doi-asserted-by": "crossref", "first-page": "89", "issue": "2", "journal-title": "J. Hosp. Infect.", "key": "10.1016/j.ijbiomac.2025.146128_bb0085", "volume": "88", "year": "2014" }, { "DOI": "10.1007/s43630-023-00381-w", "article-title": "Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen", "author": "Yao", "doi-asserted-by": "crossref", "first-page": "1323", "issue": "6", "journal-title": "Photochem. Photobiol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0090", "volume": "22", "year": "2023" }, { "DOI": "10.1021/acs.jpcb.7b07831", "article-title": "No photon wasted: an efficient and selective singlet oxygen photosensitizing protein", "author": "Westberg", "doi-asserted-by": "crossref", "first-page": "9366", "issue": "40", "journal-title": "J. Phys. Chem. B", "key": "10.1016/j.ijbiomac.2025.146128_bb0095", "volume": "121", "year": "2017" }, { "author": "World_Health_Organization", "key": "10.1016/j.ijbiomac.2025.146128_bb0100", "series-title": "Naming the Coronavirus Disease (COVID-19) and the Virus That Causes It", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30251-8", "article-title": "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding", "author": "Lu", "doi-asserted-by": "crossref", "first-page": "565", "issue": "10224", "journal-title": "Lancet", "key": "10.1016/j.ijbiomac.2025.146128_bb0105", "volume": "395", "year": "2020" }, { "DOI": "10.1038/s41586-020-2179-y", "article-title": "Structural basis of receptor recognition by SARS-CoV-2", "author": "Shang", "doi-asserted-by": "crossref", "first-page": "221", "issue": "7807", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0110", "volume": "581", "year": "2020" }, { "DOI": "10.1038/s41586-020-2180-5", "article-title": "Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor", "author": "Lan", "doi-asserted-by": "crossref", "first-page": "215", "issue": "7807", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0115", "volume": "581", "year": "2020" }, { "DOI": "10.1016/j.cell.2020.02.058", "article-title": "Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein", "author": "Walls", "doi-asserted-by": "crossref", "first-page": "281", "issue": "2", "journal-title": "Cell", "key": "10.1016/j.ijbiomac.2025.146128_bb0120", "volume": "181", "year": "2020" }, { "DOI": "10.1038/nature02145", "article-title": "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus", "author": "Li", "doi-asserted-by": "crossref", "first-page": "450", "issue": "6965", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0125", "volume": "426", "year": "2003" }, { "DOI": "10.1038/s41580-021-00418-x", "article-title": "Mechanisms of SARS-CoV-2 entry into cells", "author": "Jackson", "doi-asserted-by": "crossref", "first-page": "3", "issue": "1", "journal-title": "Nat. Rev. Mol. Cell Biol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0130", "volume": "23", "year": "2022" }, { "article-title": "Coronaviruses: An overview of their replication and pathogenesis", "author": "Fehr", "first-page": "1", "key": "10.1016/j.ijbiomac.2025.146128_bb0135", "series-title": "Coronaviruses: Methods and Protocols", "year": "2015" }, { "DOI": "10.1126/science.abb2762", "article-title": "Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "1444", "issue": "6485", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0140", "volume": "367", "year": "2020" }, { "DOI": "10.1016/j.cell.2020.03.045", "article-title": "Structural and functional basis of SARS-CoV-2 entry by using human ACE2", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "894", "issue": "4", "journal-title": "Cell", "key": "10.1016/j.ijbiomac.2025.146128_bb0145", "volume": "181", "year": "2020" }, { "DOI": "10.1126/science.abf2303", "article-title": "Structural impact on SARS-CoV-2 spike protein by D614G substitution", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "525", "issue": "6541", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0150", "volume": "372", "year": "2021" }, { "DOI": "10.1126/science.abd3255", "article-title": "Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein", "author": "Toelzer", "doi-asserted-by": "crossref", "first-page": "725", "issue": "6517", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0155", "volume": "370", "year": "2020" }, { "DOI": "10.1038/s41594-020-0468-7", "article-title": "SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects", "author": "Wrobel", "doi-asserted-by": "crossref", "first-page": "763", "issue": "8", "journal-title": "Nat. Struct. Mol. Biol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0160", "volume": "27", "year": "2020" }, { "DOI": "10.1016/j.chom.2020.11.001", "article-title": "Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles", "author": "Lu", "doi-asserted-by": "crossref", "first-page": "880", "issue": "6", "journal-title": "Cell Host Microbe", "key": "10.1016/j.ijbiomac.2025.146128_bb0165", "volume": "28", "year": "2020" }, { "DOI": "10.1038/s41586-020-2456-9", "article-title": "Convergent antibody responses to SARS-CoV-2 in convalescent individuals", "author": "Robbiani", "doi-asserted-by": "crossref", "first-page": "437", "issue": "7821", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0170", "volume": "584", "year": "2020" }, { "DOI": "10.1126/science.abd0827", "article-title": "Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail", "author": "Hansen", "doi-asserted-by": "crossref", "first-page": "1010", "issue": "6506", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0175", "volume": "369", "year": "2020" }, { "DOI": "10.1038/s41586-020-2852-1", "article-title": "SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies", "author": "Barnes", "doi-asserted-by": "crossref", "first-page": "682", "issue": "7839", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0180", "volume": "588", "year": "2020" }, { "DOI": "10.1038/s41421-024-00648-1", "article-title": "Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination", "author": "Zhao", "doi-asserted-by": "crossref", "first-page": "14", "issue": "1", "journal-title": "Cell Discovery", "key": "10.1016/j.ijbiomac.2025.146128_bb0185", "volume": "10", "year": "2024" }, { "DOI": "10.1038/s41577-022-00784-3", "article-title": "Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses", "author": "Chen", "doi-asserted-by": "crossref", "first-page": "189", "issue": "3", "journal-title": "Nat. Rev. Immunol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0190", "volume": "23", "year": "2023" }, { "DOI": "10.3390/ijms222111627", "article-title": "A collection of designed peptides to target SARS-CoV-2 spike RBD—ACE2 interaction", "author": "Fernandez-Fuentes", "doi-asserted-by": "crossref", "first-page": "11627", "issue": "21", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0195", "volume": "22", "year": "2021" }, { "DOI": "10.1016/j.compbiomed.2022.105625", "article-title": "Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region", "author": "Pourmand", "doi-asserted-by": "crossref", "journal-title": "Comput. Biol. Med.", "key": "10.1016/j.ijbiomac.2025.146128_bb0200", "volume": "146", "year": "2022" }, { "article-title": "DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic", "author": "Villa", "journal-title": "Pharmacol. Res.", "key": "10.1016/j.ijbiomac.2025.146128_bb0205", "volume": "175", "year": "2022" }, { "DOI": "10.1016/j.cell.2020.04.004", "article-title": "Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2", "author": "Monteil", "doi-asserted-by": "crossref", "first-page": "905", "issue": "4", "journal-title": "Cell", "key": "10.1016/j.ijbiomac.2025.146128_bb0210", "volume": "181", "year": "2020" }, { "DOI": "10.1038/s41594-020-00549-3", "article-title": "A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent", "author": "Xiao", "doi-asserted-by": "crossref", "first-page": "202", "issue": "2", "journal-title": "Nat. Struct. Mol. Biol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0215", "volume": "28", "year": "2021" }, { "DOI": "10.1371/journal.pone.0271359", "article-title": "High activity of an affinity-matured ACE2 decoy against omicron SARS-CoV-2 and pre-emergent coronaviruses", "author": "Sims", "doi-asserted-by": "crossref", "issue": "8", "journal-title": "PloS One", "key": "10.1016/j.ijbiomac.2025.146128_bb0220", "volume": "17", "year": "2022" }, { "DOI": "10.1038/s41598-021-91809-9", "article-title": "An ACE2 triple decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants", "author": "Tanaka", "doi-asserted-by": "crossref", "first-page": "12740", "issue": "1", "journal-title": "Sci. Rep.", "key": "10.1016/j.ijbiomac.2025.146128_bb0225", "volume": "11", "year": "2021" }, { "DOI": "10.1021/acsptsci.2c00180", "article-title": "Engineering an ACE2-derived fragment as a decoy for novel SARS-CoV-2 virus", "author": "Renzi", "doi-asserted-by": "crossref", "first-page": "857", "issue": "6", "journal-title": "ACS Pharmacol. Transl. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0230", "volume": "6", "year": "2023" }, { "DOI": "10.15252/emmm.202216109", "article-title": "An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2", "author": "Zhang", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "EMBO Mol. Med.", "key": "10.1016/j.ijbiomac.2025.146128_bb0235", "volume": "14", "year": "2022" }, { "DOI": "10.3389/fimmu.2023.1204543", "article-title": "A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells", "author": "Kegler", "doi-asserted-by": "crossref", "journal-title": "Front. Immunol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0240", "volume": "14", "year": "2023" }, { "DOI": "10.1080/22221751.2022.2079426", "article-title": "ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "1488", "issue": "1", "journal-title": "Emerg. Microbes Infect.", "key": "10.1016/j.ijbiomac.2025.146128_bb0245", "volume": "11", "year": "2022" }, { "DOI": "10.1073/pnas.2303509120", "article-title": "Vectored immunoprophylaxis and treatment of SARS-CoV-2 infection in a preclinical model", "author": "Tada", "doi-asserted-by": "crossref", "issue": "23", "journal-title": "Proc. Natl. Acad. Sci. U. S. A.", "key": "10.1016/j.ijbiomac.2025.146128_bb0250", "volume": "120", "year": "2023" }, { "DOI": "10.1126/sciadv.abf1738", "article-title": "An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants", "author": "Chan", "doi-asserted-by": "crossref", "issue": "8", "journal-title": "Sci. Adv.", "key": "10.1016/j.ijbiomac.2025.146128_bb0255", "volume": "7", "year": "2021" }, { "DOI": "10.1038/s42003-023-04860-9", "article-title": "A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo", "author": "Havranek", "doi-asserted-by": "crossref", "first-page": "513", "issue": "1", "journal-title": "Commun. Biol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0260", "volume": "6", "year": "2023" }, { "DOI": "10.1038/s41598-023-27636-x", "article-title": "Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations", "author": "Köchl", "doi-asserted-by": "crossref", "first-page": "774", "issue": "1", "journal-title": "Sci. Rep.", "key": "10.1016/j.ijbiomac.2025.146128_bb0265", "volume": "13", "year": "2023" }, { "DOI": "10.1021/acs.bioconjchem.2c00067", "article-title": "Versatile supramolecular complex for targeted antimicrobial photodynamic inactivation", "author": "Mussini", "doi-asserted-by": "crossref", "first-page": "666", "issue": "4", "journal-title": "Bioconjug. Chem.", "key": "10.1016/j.ijbiomac.2025.146128_bb0270", "volume": "33", "year": "2022" }, { "DOI": "10.3390/ijms25115751", "article-title": "Concanavalin A delivers a photoactive protein to the bacterial wall", "author": "Mussini", "doi-asserted-by": "crossref", "first-page": "5751", "issue": "11", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0275", "volume": "25", "year": "2024" }, { "DOI": "10.1007/s40766-022-00031-4", "article-title": "Photodynamic treatment of pathogens", "author": "Delcanale", "doi-asserted-by": "crossref", "first-page": "407", "journal-title": "Riv. Nuovo Cimento", "key": "10.1016/j.ijbiomac.2025.146128_bb0280", "volume": "405", "year": "2022" }, { "DOI": "10.3390/molecules200610604", "article-title": "Antiviral, antifungal and antibacterial activities of a BODIPY-based photosensitizer", "author": "Carpenter", "doi-asserted-by": "crossref", "first-page": "10604", "issue": "6", "journal-title": "Molecules", "key": "10.1016/j.ijbiomac.2025.146128_bb0285", "volume": "20", "year": "2015" }, { "DOI": "10.1039/c9pp00211a", "article-title": "Trends and targets in antiviral phototherapy", "author": "Wiehe", "doi-asserted-by": "crossref", "first-page": "2565", "issue": "11", "journal-title": "Photochem. Photobiol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0290", "volume": "18", "year": "2019" }, { "DOI": "10.1016/j.addr.2021.05.032", "article-title": "Can microorganisms develop resistance against light based anti-infective agents?", "author": "Marasini", "doi-asserted-by": "crossref", "journal-title": "Adv. Drug Deliv. Rev.", "key": "10.1016/j.ijbiomac.2025.146128_bb0295", "volume": "175", "year": "2021" }, { "DOI": "10.1038/s43586-021-00038-x", "article-title": "Single-molecule localization microscopy", "author": "Lelek", "doi-asserted-by": "crossref", "first-page": "39", "issue": "1", "journal-title": "Nat. Rev. Methods Prim.", "key": "10.1016/j.ijbiomac.2025.146128_bb0300", "volume": "1", "year": "2021" }, { "DOI": "10.1038/ncomms7701", "article-title": "Encoding and decoding spatio-temporal information for super-resolution microscopy", "author": "Lanzanò", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.ijbiomac.2025.146128_bb0305", "volume": "6", "year": "2015" }, { "DOI": "10.1007/s40766-020-00008-1", "article-title": "Optical nanoscopy", "author": "Diaspro", "doi-asserted-by": "crossref", "first-page": "385", "issue": "8", "journal-title": "La Rivista del Nuovo Cimento", "key": "10.1016/j.ijbiomac.2025.146128_bb0310", "volume": "43", "year": "2020" }, { "DOI": "10.1038/s41592-019-0515-7", "article-title": "Parameter-free image resolution estimation based on decorrelation analysis", "author": "Descloux", "doi-asserted-by": "crossref", "first-page": "918", "issue": "9", "journal-title": "Nat. Methods", "key": "10.1016/j.ijbiomac.2025.146128_bb0315", "volume": "16", "year": "2019" }, { "DOI": "10.1007/s12250-020-00230-5", "article-title": "On the calculation of TCID50 for quantitation of virus infectivity", "author": "Lei", "doi-asserted-by": "crossref", "first-page": "141", "issue": "1", "journal-title": "Virol. Sin.", "key": "10.1016/j.ijbiomac.2025.146128_bb0320", "volume": "36", "year": "2021" }, { "DOI": "10.1038/s41586-020-2665-2", "article-title": "Structures and distributions of SARS-CoV-2 spike proteins on intact virions", "author": "Ke", "doi-asserted-by": "crossref", "first-page": "498", "issue": "7838", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0325", "volume": "588", "year": "2020" }, { "DOI": "10.4049/immunohorizons.2200005", "article-title": "Inactivation of SARS-CoV-2 and COVID-19 patient samples for contemporary immunology and metabolomics studies", "author": "Eddins", "doi-asserted-by": "crossref", "first-page": "144", "issue": "2", "journal-title": "ImmunoHorizons", "key": "10.1016/j.ijbiomac.2025.146128_bb0330", "volume": "6", "year": "2022" }, { "DOI": "10.1039/c0pp00213e", "article-title": "Singlet oxygen: there is still something new under the sun, and it is better than ever", "author": "Ogilby", "doi-asserted-by": "crossref", "first-page": "1543", "journal-title": "Photochem. Photobiol. Sci.", "key": "10.1016/j.ijbiomac.2025.146128_bb0335", "volume": "9", "year": "2010" }, { "DOI": "10.1039/b926014p", "article-title": "Singlet oxygen: there is indeed something new under the sun", "author": "Ogilby", "doi-asserted-by": "crossref", "first-page": "3181", "issue": "8", "journal-title": "Chem. Soc. Rev.", "key": "10.1016/j.ijbiomac.2025.146128_bb0340", "volume": "39", "year": "2010" }, { "DOI": "10.1111/j.1751-1097.2008.00359.x", "article-title": "Time-resolved singlet oxygen phosphorescence measurements from photosensitized experiments in single cells: effects of oxygen diffusion and oxygen concentration", "author": "Hatz", "doi-asserted-by": "crossref", "first-page": "1284", "issue": "5", "journal-title": "Photochem. Photobiol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0345", "volume": "84", "year": "2008" }, { "DOI": "10.1021/jp206739y", "article-title": "Irradiation- and sensitizer-dependent changes in the lifetime of intracellular singlet oxygen produced in a photosensitized process", "author": "da Silva", "doi-asserted-by": "crossref", "first-page": "445", "issue": "1", "journal-title": "J. Phys. Chem. B", "key": "10.1016/j.ijbiomac.2025.146128_bb0350", "volume": "116", "year": "2012" }, { "DOI": "10.1021/acsomega.0c03830", "article-title": "Visible light spectroscopic analysis of methylene blue in water; what comes after dimer?", "author": "Fernández-Pérez", "doi-asserted-by": "crossref", "first-page": "29801", "issue": "46", "journal-title": "ACS Omega", "key": "10.1016/j.ijbiomac.2025.146128_bb0355", "volume": "5", "year": "2020" }, { "DOI": "10.1016/0003-2697(89)90602-7", "article-title": "Calculation of protein extinction coefficients from amino acid sequence data", "author": "Gill", "doi-asserted-by": "crossref", "first-page": "319", "issue": "2", "journal-title": "Anal. Biochem.", "key": "10.1016/j.ijbiomac.2025.146128_bb0360", "volume": "182", "year": "1989" }, { "DOI": "10.1016/S1572-1000(05)00097-9", "article-title": "Methylene blue in photodynamic therapy: from basic mechanisms to clinical applications", "author": "Tardivo", "doi-asserted-by": "crossref", "first-page": "175", "issue": "3", "journal-title": "Photodiagnosis Photodyn. Ther.", "key": "10.1016/j.ijbiomac.2025.146128_bb0365", "volume": "2", "year": "2005" }, { "DOI": "10.1016/j.molliq.2014.06.030", "article-title": "Dimerization of methylene blue in aqueous and mixed aqueous organic solvent: a spectroscopic study", "author": "Florence", "doi-asserted-by": "crossref", "first-page": "255", "journal-title": "J. Mol. Liq.", "key": "10.1016/j.ijbiomac.2025.146128_bb0370", "volume": "198", "year": "2014" }, { "DOI": "10.1039/b109753a", "article-title": "Modulation of methylene blue photochemical properties based on adsorption at aqueous micelle interfaces", "author": "Junqueira", "doi-asserted-by": "crossref", "first-page": "2320", "issue": "11", "journal-title": "Phys. Chem. Chem. Phys.", "key": "10.1016/j.ijbiomac.2025.146128_bb0375", "volume": "4", "year": "2002" }, { "DOI": "10.1021/j100483a006", "article-title": "Calorimetric determinations of absolute fluorescence quantum yields", "author": "Olmsted", "doi-asserted-by": "crossref", "first-page": "2581", "issue": "20", "journal-title": "J. Phys. Chem.", "key": "10.1016/j.ijbiomac.2025.146128_bb0380", "volume": "83", "year": "1979" }, { "author": "Public Health Image Library", "key": "10.1016/j.ijbiomac.2025.146128_bb0385" }, { "DOI": "10.1080/19420862.2016.1212148", "article-title": "Fluorescence correlation spectroscopy as a sensitive and useful tool for revealing potential overlaps between the epitopes of monoclonal antibodies on viral particles", "author": "Richert", "doi-asserted-by": "crossref", "first-page": "1235", "issue": "7", "journal-title": "MAbs", "key": "10.1016/j.ijbiomac.2025.146128_bb0390", "volume": "8", "year": "2016" }, { "DOI": "10.1016/j.bios.2009.04.005", "article-title": "Ultrasensitive Qbeta phage analysis using fluorescence correlation spectroscopy on an optofluidic chip", "author": "Rudenko", "doi-asserted-by": "crossref", "first-page": "3258", "issue": "11", "journal-title": "Biosens. Bioelectron.", "key": "10.1016/j.ijbiomac.2025.146128_bb0395", "volume": "24", "year": "2009" }, { "DOI": "10.1364/BOE.4.001646", "article-title": "Enumerating virus-like particles in an optically concentrated suspension by fluorescence correlation spectroscopy", "author": "Hu", "doi-asserted-by": "crossref", "first-page": "1646", "issue": "9", "journal-title": "Biomed. Opt. Express", "key": "10.1016/j.ijbiomac.2025.146128_bb0400", "volume": "4", "year": "2013" }, { "DOI": "10.1038/s41586-020-2665-2", "article-title": "Structures and distributions of SARS-CoV-2 spike proteins on intact virions", "author": "Ke", "doi-asserted-by": "crossref", "first-page": "498", "issue": "7838", "journal-title": "Nature", "key": "10.1016/j.ijbiomac.2025.146128_bb0405", "volume": "588", "year": "2020" }, { "DOI": "10.1126/science.abd5223", "article-title": "In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges", "author": "Turoňová", "doi-asserted-by": "crossref", "first-page": "203", "issue": "6513", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0410", "volume": "370", "year": "2020" }, { "DOI": "10.1126/science.abd4251", "article-title": "Distinct conformational states of SARS-CoV-2 spike protein", "author": "Cai", "doi-asserted-by": "crossref", "first-page": "1586", "issue": "6511", "journal-title": "Science", "key": "10.1016/j.ijbiomac.2025.146128_bb0415", "volume": "369", "year": "2020" }, { "DOI": "10.3389/fmedt.2021.694347", "article-title": "Up state of the SARS-COV-2 spike homotrimer favors an increased virulence for new variants", "author": "Giron", "doi-asserted-by": "crossref", "journal-title": "Front. Med. Technol.", "key": "10.1016/j.ijbiomac.2025.146128_bb0420", "volume": "3", "year": "2021" }, { "DOI": "10.1371/journal.ppat.1011484", "article-title": "High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization", "author": "McMahon", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "PLoS Pathog.", "key": "10.1016/j.ijbiomac.2025.146128_bb0425", "volume": "19", "year": "2023" }, { "DOI": "10.1016/j.bbadis.2022.166347", "article-title": "Virus morphology: insights from super-resolution fluorescence microscopy", "author": "Robb", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "Biochim. Biophys. Acta (BBA) - Mol. Basis Dis.", "key": "10.1016/j.ijbiomac.2025.146128_bb0430", "volume": "1868", "year": "2022" } ], "reference-count": 86, "references-count": 86, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0141813025066851" } }, "score": 1, "short-title": [], "source": "Crossref", "special_numbering": "P4", "subject": [], "subtitle": [], "title": "Angiotensin Converting Enzyme 2 is a molecular decoy for targeted photodynamic SARS-CoV-2 inactivation", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "volume": "320" }