Evaluating NSAIDs in SARS-CoV-2: Immunomodulatory mechanisms and future therapeutic strategies

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Med.'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2024.e25734_bib8', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pmed.1003308', 'article-title': 'Adverse outcomes and mortality in users of non-steroidal ' 'anti-inflammatory drugs who tested positive for SARS-CoV-2: a Danish ' 'nationwide cohort study', 'volume': '17', 'author': 'Lund', 'year': '2020', 'journal-title': 'PLoS Med.'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2024.e25734_bib9', 'doi-asserted-by': 'crossref', 'first-page': 'e498', 'DOI': '10.1016/S2665-9913(21)00104-1', 'article-title': 'Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in ' 'the ISARIC Clinical Characterisation Protocol UK cohort: a matched, ' 'prospective cohort study', 'volume': '3', 'author': 'Drake', 'year': '2021', 'journal-title': 'The Lancet Rheumatology'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib10', 'first-page': '288', 'article-title': 'NSAIDs: a double edged sword in viral infections', 'volume': '9', 'author': 'Gerges', 'year': '2022', 'journal-title': 'International Journal of Medical Reviews'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib11', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.phrs.2020.104849', 'article-title': 'NSAIDs in patients with viral infections, including Covid-19: victims ' 'or perpetrators?', 'volume': '157', 'author': 'Capuano', 'year': '2020', 'journal-title': 'Pharmacol. Res.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib12', 'series-title': 'D S A D D A S D MEDICAL REVIEWS Mini Review NSAIDs: A Double Edged Sword ' 'in Viral Infections', 'author': 'Thabet', 'year': '2022'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib13', 'unstructured': 'Fukunaga, K., et al., Cyclooxygenase 2 Plays a Pivotal Role in the ' 'Resolution of Acute Lung Injury. (0022-1767 (Print))..'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib14', 'unstructured': 'Carey, M.A., et al., Contrasting Effects of Cyclooxygenase-1 (COX-1) and ' 'COX-2 Deficiency on the Host Response to Influenza A Viral Infection. ' '(0022-1767 (Print))..'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2024.e25734_bib15', 'doi-asserted-by': 'crossref', 'first-page': '2693', 'DOI': '10.1002/jmv.26139', 'article-title': 'Increasing host cellular receptor—angiotensin-converting enzyme 2 ' 'expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) ' 'infection', 'volume': '92', 'author': 'Zhuang', 'year': '2020', 'journal-title': 'J. Med. Virol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib16', 'doi-asserted-by': 'crossref', 'first-page': '9606', 'DOI': '10.1038/s41598-021-88313-5', 'article-title': 'Network pharmacology approach to decipher signaling pathways associated ' 'with target proteins of NSAIDs against COVID-19', 'volume': '11', 'author': 'Oh', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib17', 'unstructured': 'Saheb Sharif-Askari, N., et al., Effect of Common Medications on the ' 'Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue. (1752-8062 ' '(Electronic))..'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2024.e25734_bib18', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/ph15060696', 'article-title': 'Analgesics induce alterations in the expression of SARS-CoV-2 entry and ' 'arachidonic-acid-metabolizing genes in the mouse lungs', 'volume': '15', 'author': 'Khirfan', 'year': '2022', 'journal-title': 'Pharmaceuticals'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib19', 'doi-asserted-by': 'crossref', 'first-page': '84', 'DOI': '10.1186/s12985-022-01813-2', 'article-title': 'NSAID use and clinical outcomes in COVID-19 patients: a 38-center ' 'retrospective cohort study', 'volume': '19', 'author': 'Reese', 'year': '2022', 'journal-title': 'Virol. J.'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2024.e25734_bib20', 'doi-asserted-by': 'crossref', 'first-page': '1742', 'DOI': '10.1182/blood.V97.6.1742', 'article-title': 'Selective inhibition of interleukin-4 gene expression in human T cells ' 'by aspirin', 'volume': '97', 'author': 'Cianferoni', 'year': '2001', 'journal-title': 'Blood'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib21', 'doi-asserted-by': 'crossref', 'first-page': '109', 'DOI': '10.1097/JS9.0000000000000101', 'article-title': 'Prospective role of NSAIDs with antiviral properties for ' 'pharmacological management of postsurgical procedures during COVID-19', 'volume': '109', 'author': 'Nainu', 'year': '2023', 'journal-title': 'Int. J. Surg.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib22', 'doi-asserted-by': 'crossref', 'unstructured': 'Alfajaro, M.M., et al., Activation of COX-2/PGE2 Promotes Sapovirus ' 'Replication via the Inhibition of Nitric Oxide Production. LID - ' '10.1128/JVI.01656-16 [doi] LID - e01656-16. 2017(1098-5514 ' '(Electronic))..', 'DOI': '10.1128/JVI.01656-16'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib23', 'series-title': 'NSAID Treatment Suppresses VSV Propagation in Mouse CNS', 'author': 'Chen', 'year': '2000'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib24', 'series-title': 'Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on ' 'the Host Response to Influenza A Viral Infection', 'author': 'Carey', 'year': '2005'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib25', 'series-title': 'W.H.O. The Use of Non-steroidal Anti-inflammatory Drugs (NSAIDs) in ' 'Patients with COVID-19', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib26', 'series-title': 'Possible Effects of Repeated Exposure to Ibuprofen and Acetaminophen on ' 'the Intestinal Immune Response in Young Infants', 'first-page': '1532', 'author': 'Langhendries', 'year': '2016'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2024.e25734_bib27', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/jcm8060786', 'article-title': 'Risks related to the use of non-steroidal anti-inflammatory drugs in ' 'community-acquired pneumonia in adult and pediatric patients', 'volume': '8', 'author': 'Voiriot', 'year': '2019', 'journal-title': 'J. Clin. Med.'}, { 'issue': '7503', 'key': '10.1016/j.heliyon.2024.e25734_bib28', 'doi-asserted-by': 'crossref', 'first-page': '92', 'DOI': '10.1038/nature13479', 'article-title': 'Pro-resolving lipid mediators are leads for resolution physiology', 'volume': '510', 'author': 'Serhan', 'year': '2014', 'journal-title': 'Nature'}, { 'issue': '29', 'key': '10.1016/j.heliyon.2024.e25734_bib29', 'doi-asserted-by': 'crossref', 'DOI': '10.1126/sciadv.adh5552', 'article-title': 'Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to ' 'Clostridioides difficile toxin–mediated mitochondrial damage', 'volume': '9', 'author': 'Soto Ocaña', 'year': '2023', 'journal-title': 'Sci. Adv.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib30', 'doi-asserted-by': 'crossref', 'first-page': 'e33', 'DOI': '10.1016/j.ejim.2017.03.004', 'article-title': 'Bacterial infections and NSAIDs exposure? Seek septic complications', 'volume': '41', 'author': 'Le Turnier', 'year': '2017', 'journal-title': 'Eur. J. Intern. Med.'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2024.e25734_bib31', 'doi-asserted-by': 'crossref', 'first-page': '355', 'DOI': '10.1016/j.therap.2020.05.003', 'article-title': 'Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 ' 'infection', 'volume': '75', 'author': 'Micallef', 'year': '2020', 'journal-title': 'Therapies'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib32', 'doi-asserted-by': 'crossref', 'first-page': 'R43', 'DOI': '10.1186/cc7766', 'article-title': 'A multicentre case-control study of nonsteroidal anti-inflammatory ' 'drugs as a risk factor for severe sepsis and septic shock', 'volume': '13', 'author': 'Legras', 'year': '2009', 'journal-title': 'Crit. Care'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2024.e25734_bib33', 'article-title': 'Antimicrobial properties on non-antibiotic drugs in the era of ' 'increased bacterial resistance', 'volume': '9', 'author': 'Lagadinou', 'year': '2020', 'journal-title': 'Antibiotics (Basel)'}, { 'issue': '12', 'key': '10.1016/j.heliyon.2024.e25734_bib34', 'doi-asserted-by': 'crossref', 'first-page': '854', 'DOI': '10.1038/nrd.2018.210', 'article-title': 'Trial watch: the clinical trial landscape for PD1/PDL1 immune ' 'checkpoint inhibitors', 'author': 'Tang', 'year': '2018', 'journal-title': 'Nat. Rev. Drug Discov.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib35', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fonc.2021.637504', 'article-title': 'Cyclooxygenase-2 inhibitor: a potential combination strategy with ' 'immunotherapy in cancer', 'volume': '11', 'author': 'Pu', 'year': '2021', 'journal-title': 'Front. Oncol.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2024.e25734_bib36', 'doi-asserted-by': 'crossref', 'first-page': '4637', 'DOI': '10.21873/anticanres.12768', 'article-title': 'Impact of COX2 inhibitor for regulation of PD-L1 expression in ' 'non-small cell lung cancer', 'volume': '38', 'author': 'Shimizu', 'year': '2018', 'journal-title': 'Anticancer Res.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib37', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fonc.2021.648139', 'article-title': 'Immune checkpoint inhibition for triple-negative breast cancer: current ' 'landscape and future perspectives', 'volume': '11', 'author': 'Yi', 'year': '2021', 'journal-title': 'Front. Oncol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib38', 'doi-asserted-by': 'crossref', 'first-page': '30', 'DOI': '10.1111/imm.13588', 'article-title': 'CD8+ T cell exhaustion in anti‐tumour immunity: the new insights for ' 'cancer immunotherapy', 'volume': '168', 'author': 'Huang', 'year': '2023', 'journal-title': 'Immunology'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib39', 'series-title': 'Non-steroidal Anti-inflammatory Drugs, Tumour Immunity and Immunotherapy', 'author': 'Hussain', 'year': '2012'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib40', 'doi-asserted-by': 'crossref', 'first-page': '63', 'DOI': '10.1016/j.yjmcc.2020.05.007', 'article-title': 'p38 MAPK inhibition: a promising therapeutic approach for COVID-19', 'volume': '144', 'author': 'Grimes', 'year': '2020', 'journal-title': 'J. Mol. Cell. Cardiol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib41', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/ar-2002-75400', 'article-title': 'NSAIDs inhibit p38 MAPK activation', 'volume': '4', 'author': 'Smythe', 'year': '2002', 'journal-title': 'Arthritis Res. Ther.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib42', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2022.105475', 'article-title': 'Inhibition of p38 signaling curtails the SARS-CoV-2 induced ' 'inflammatory response but retains the IFN-dependent antiviral defense ' 'of the lung epithelial barrier', 'volume': '209', 'author': 'Faist', 'year': '2023', 'journal-title': 'Antivir. Res.'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2024.e25734_bib43', 'doi-asserted-by': 'crossref', 'first-page': '3724', 'DOI': '10.1002/ptr.7902', 'article-title': 'Therapeutic prospects of naturally occurring p38 MAPK inhibitors ' 'tanshinone IIA and pinocembrin for the treatment of SARS-CoV-2-induced ' 'CNS complications', 'volume': '37', 'author': 'Valipour', 'year': '2023', 'journal-title': 'Phytother Res.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib44', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2021.781352', 'article-title': 'IL1β promotes TMPRSS2 expression and SARS-CoV-2 cell entry through the ' 'p38 MAPK-GATA2 Axis', 'volume': '12', 'author': 'Cioccarelli', 'year': '2021', 'journal-title': 'Front. Immunol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib45', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fphar.2021.631879', 'article-title': 'SARS-CoV-2 switches ‘on’ MAPK and NFκB signaling via the reduction of ' 'nuclear DUSP1 and DUSP5 expression', 'volume': '12', 'author': 'Goel', 'year': '2021', 'journal-title': 'Front. Pharmacol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib46', 'doi-asserted-by': 'crossref', 'first-page': '219', 'DOI': '10.1016/bs.aivir.2016.08.006', 'article-title': 'Interaction of SARS and MERS coronaviruses with the antiviral ' 'interferon response', 'volume': '96', 'author': 'Kindler', 'year': '2016', 'journal-title': 'Adv. Virus Res.'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2024.e25734_bib47', 'doi-asserted-by': 'crossref', 'first-page': '1586', 'DOI': '10.1096/fj.06-6589com', 'article-title': 'Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via ' 'both calcium-dependent and calcium-independent protein kinase C ' 'pathways', 'volume': '21', 'author': 'Liu', 'year': '2007', 'journal-title': 'Faseb. J.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2024.e25734_bib48', 'doi-asserted-by': 'crossref', 'first-page': '1417', 'DOI': '10.1016/j.biocel.2006.02.003', 'article-title': 'Nucleocapsid protein of SARS-CoV activates the expression of ' 'cyclooxygenase-2 by binding directly to regulatory elements for nuclear ' 'factor-kappa B and CCAAT/enhancer binding protein', 'volume': '38', 'author': 'Yan', 'year': '2006', 'journal-title': 'Int. J. Biochem. Cell Biol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib49', 'series-title': 'Angiotensin-converting Enzyme 2 Is a Functional Receptor for the SARS ' 'Coronavirus', 'first-page': '1476', 'author': 'Li', 'year': '2003'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib50', 'series-title': 'The Race to Treat COVID-19: Potential Therapeutic Agents for the ' 'Prevention and Treatment of SARS-CoV-2', 'author': 'Shagufta', 'year': '2021'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2024.e25734_bib51', 'doi-asserted-by': 'crossref', 'first-page': '4122', 'DOI': '10.1128/JVI.02232-10', 'article-title': 'Evidence that TMPRSS2 activates the severe acute respiratory syndrome ' 'coronavirus spike protein for membrane fusion and reduces viral control ' 'by the humoral immune response', 'volume': '85', 'author': 'Glowacka', 'year': '2011', 'journal-title': 'J. Virol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib52', 'series-title': 'SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a ' 'Clinically Proven Protease Inhibitor', 'author': 'Hoffmann', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib53', 'author': 'Hamidi', 'year': '2021', 'journal-title': 'Role of pirfenidone in TGF-β pathways and other inflammatory pathways ' 'in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a ' 'theoretical perspective'}, { 'issue': '23', 'key': '10.1016/j.heliyon.2024.e25734_bib54', 'doi-asserted-by': 'crossref', 'DOI': '10.1128/JVI.01257-21', 'article-title': 'The NF-κB transcriptional footprint is essential for SARS-CoV-2 ' 'replication', 'volume': '95', 'author': 'Nilsson-Payant', 'year': '2021', 'journal-title': 'J. Virol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib55', 'doi-asserted-by': 'crossref', 'first-page': '127', 'DOI': '10.1038/s41541-021-00391-8', 'article-title': 'Exploiting viral sensing mediated by Toll-like receptors to design ' 'innovative vaccines', 'volume': '6', 'author': 'Sartorius', 'year': '2021', 'journal-title': 'npj Vaccines'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib56', 'series-title': 'Single-cell RNA-Seq Data Analysis on the Receptor ACE2 Expression ' 'Reveals the Potential Risk of Different Human Organs Vulnerable to ' '2019-nCoV Infection', 'author': 'Zou', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib57', 'series-title': 'Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 ' 'Knockout Mice', 'author': 'Alghamri', 'year': '2013'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib58', 'series-title': 'The Novel Angiotensin-Converting Enzyme (ACE) Homolog, ACE2, Is ' 'Selectively Expressed by Adult Leydig Cells of the Testis', 'author': 'Douglas', 'year': '2004'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib59', 'first-page': '1758', 'volume': 'vol. 2021', 'author': 'Coto', 'year': '2019'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib60', 'series-title': 'Angiotensin-converting Enzyme 2 (ACE2) as a SARS-CoV-2 Receptor: ' 'Molecular Mechanisms and Potential Therapeutic Target', 'author': 'Zhang', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib61', 'series-title': 'Coronavirus Disease 2019 (COVID-19) and the Renin-Angiotensin System: A ' 'Closer Look at Angiotensin-Converting Enzyme 2 (ACE2)', 'author': 'Zemlin', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib62', 'series-title': 'COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women ' 'and Children', 'author': 'Ciaglia', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib63', 'series-title': 'Effects of Nonsteroidal Anti-inflammatory Drugs on Serum Proinflammatory ' 'Cytokines in the Treatment of Ankylosing Spondylitis', 'author': 'Yan', 'year': '2018'}, { 'issue': '10', 'key': '10.1016/j.heliyon.2024.e25734_bib64', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/v12101092', 'article-title': 'Potential anti-SARS-CoV-2 therapeutics that target the post-entry ' 'stages of the viral life cycle: a comprehensive review', 'volume': '12', 'author': 'Al-Horani', 'year': '2020', 'journal-title': 'Viruses'}, { 'issue': '7821', 'key': '10.1016/j.heliyon.2024.e25734_bib65', 'doi-asserted-by': 'crossref', 'first-page': '463', 'DOI': '10.1038/s41586-020-2588-y', 'article-title': 'Longitudinal analyses reveal immunological misfiring in severe COVID-19', 'volume': '584', 'author': 'Lucas', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib66', 'series-title': 'The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19. ' 'LID - 10.3390/biology10090852', 'author': 'Nechipurenko', 'year': '2021'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib67', 'article-title': 'SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia ' 'through spike protein', 'author': 'Albornoz', 'year': '2022', 'journal-title': 'Mol. Psychiatr.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib68', 'doi-asserted-by': 'crossref', 'first-page': '8', 'DOI': '10.1016/j.coi.2018.03.010', 'article-title': 'Ion homeostasis and ion channels in NLRP3 inflammasome activation and ' 'regulation', 'volume': '52', 'author': 'Hafner-Bratkovic', 'year': '2018', 'journal-title': 'Curr. Opin. Immunol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib69', 'series-title': 'Nonsteroid Anti-inflammatory Drugs Inhibit Both the Activity and the ' 'Inflammation-Induced Expression of Acid-Sensing Ion Channels in ' 'Nociceptors', 'first-page': '1529', 'author': 'Voilley', 'year': '2001'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2024.e25734_bib70', 'doi-asserted-by': 'crossref', 'first-page': '469', 'DOI': '10.1002/ddr.21794', 'article-title': 'Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy', 'volume': '82', 'author': 'Prasher', 'year': '2021', 'journal-title': 'Drug Dev. Res.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib71', 'doi-asserted-by': 'crossref', 'DOI': '10.1177/1756286420935676', 'article-title': "Diclofenac reduces the risk of Alzheimer's disease: a pilot analysis of " 'NSAIDs in two US veteran populations', 'volume': '13', 'author': 'Stuve', 'year': '2020', 'journal-title': 'Ther Adv Neurol Disord'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib72', 'doi-asserted-by': 'crossref', 'first-page': '63', 'DOI': '10.1038/s41467-020-20247-4', 'article-title': 'Neutralizing antibody titres in SARS-CoV-2 infections', 'volume': '12', 'author': 'Lau', 'year': '2021', 'journal-title': 'Nat. Commun.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib73', 'doi-asserted-by': 'crossref', 'first-page': '18', 'DOI': '10.1016/j.cellimm.2009.03.007', 'article-title': 'Ibuprofen and other widely used non-steroidal anti-inflammatory drugs ' 'inhibit antibody production in human cells', 'volume': '258', 'author': 'Bancos', 'year': '2009', 'journal-title': 'Cell. Immunol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib74', 'doi-asserted-by': 'crossref', 'first-page': '8920', 'DOI': '10.1038/s41598-021-88356-8', 'article-title': 'Analysis of IgM, IgA, and IgG isotype antibodies Directed against ' 'SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19', 'volume': '11', 'author': 'Meinberger', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2024.e25734_bib75', 'article-title': 'Risk factors of SARS-CoV-2 infection: global epidemiological study', 'volume': '2', 'author': 'Barletta', 'year': '2021', 'journal-title': 'JMIRx Med'}, { 'issue': '9', 'key': '10.1016/j.heliyon.2024.e25734_bib76', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/molecules26092593', 'article-title': 'Antiviral properties of the NSAID drug naproxen targeting the ' 'nucleoprotein of SARS-CoV-2 coronavirus', 'volume': '26', 'author': 'Terrier', 'year': '2021', 'journal-title': 'Molecules'}, { 'issue': '5', 'key': '10.1016/j.heliyon.2024.e25734_bib77', 'doi-asserted-by': 'crossref', 'first-page': '2231', 'DOI': '10.1128/AAC.02335-12', 'article-title': 'Structure-based discovery of the novel antiviral properties of naproxen ' 'against the nucleoprotein of influenza A virus', 'volume': '57', 'author': 'Lejal', 'year': '2013', 'journal-title': 'Antimicrob. Agents Chemother.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib78', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.compbiomed.2021.104686', 'article-title': 'Potential inhibitors of the main protease of SARS-CoV-2 and modulators ' 'of arachidonic acid pathway: non-steroidal anti-inflammatory drugs ' 'against COVID-19', 'volume': '136', 'author': 'Sisakht', 'year': '2021', 'journal-title': 'Comput. Biol. Med.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib79', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.micpath.2020.104641', 'article-title': 'Structural and functional insights into non-structural proteins of ' 'coronaviruses', 'volume': '150', 'author': 'Rohaim', 'year': '2021', 'journal-title': 'Microb. Pathog.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib80', 'doi-asserted-by': 'crossref', 'first-page': '4684', 'DOI': '10.1016/j.csbj.2021.08.029', 'article-title': 'Co-crystallization and structure determination: an effective direction ' 'for anti-SARS-CoV-2 drug discovery', 'volume': '19', 'author': 'Wang', 'year': '2021', 'journal-title': 'Comput. Struct. Biotechnol. J.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib81', 'series-title': 'Structural and Biochemical Characterization of Nsp12-Nsp7-Nsp8 Core ' 'Polymerase Complex from COVID-19 Virus', 'author': 'Peng', 'year': '2020'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib82', 'doi-asserted-by': 'crossref', 'first-page': '17', 'DOI': '10.1080/14787210.2021.1939683', 'article-title': 'NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential ' 'mitigation of the cytokine storm interleukin-6 amplifier via ' 'immunomodulatory effects', 'volume': '20', 'author': 'Kelleni', 'year': '2022', 'journal-title': 'Expert Rev. Anti-infect. Ther.'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2024.e25734_bib83', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/v13040558', 'article-title': 'In vitro assessment of the antiviral activity of ketotifen, ' 'indomethacin and naproxen, alone and in combination, against SARS-CoV-2', 'volume': '13', 'author': 'Kiani', 'year': '2021', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib84', 'series-title': 'Inhibition of Highly Pathogenic Avian H5N1 Influenza Virus Propagation ' 'by RNA Oligonucleotides Targeting the PB2 Gene in Combination with ' 'Celecoxib', 'first-page': '1521', 'author': 'Jin', 'year': '2011'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib85', 'series-title': 'Hospitalized COVID-19 Patients Treated with Celecoxib and High Dose ' 'Famotidine Adjuvant Therapy Show Significant Clinical Responses', 'author': 'Tomera', 'year': '2020'}, { 'issue': '13', 'key': '10.1016/j.heliyon.2024.e25734_bib86', 'doi-asserted-by': 'crossref', 'first-page': '7001', 'DOI': '10.1073/pnas.2002589117', 'article-title': 'Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells', 'volume': '117', 'author': 'Matsuyama', 'year': '2020', 'journal-title': 'Proc. Natl. Acad. Sci. USA'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib87', 'first-page': '116', 'article-title': 'A review of COVID-19 (Coronavirus Disease-2019) diagnosis, treatments ' 'and prevention', 'volume': '4', 'author': 'Hafeez', 'year': '2020', 'journal-title': 'Ejmo'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib88', 'article-title': 'Current status and future directions of bacteria-based immunotherapy', 'volume': '13', 'author': 'Tang', 'year': '2022', 'journal-title': 'Front. Immunol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib89', 'doi-asserted-by': 'crossref', 'first-page': '1603', 'DOI': '10.1007/s00277-021-04452-9', 'volume': '100', 'author': 'Classen', 'year': '2021', 'journal-title': 'Ann. Hematol.'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib90', 'doi-asserted-by': 'crossref', 'first-page': '121', 'DOI': '10.1038/s41577-022-00734-z', 'article-title': 'Host-directed immunotherapy of viral and bacterial infections: past, ' 'present and future', 'volume': '23', 'author': 'Wallis', 'year': '2023', 'journal-title': 'Nat. Rev. Immunol.'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2024.e25734_bib91', 'doi-asserted-by': 'crossref', 'first-page': '3114', 'DOI': '10.1111/bcp.15281', 'article-title': 'Immunomodulatory effects of pharmaceutical opioids and antipyretic ' 'analgesics: mechanisms and relevance to infection', 'volume': '88', 'author': 'Abdel Shaheed', 'year': '2022', 'journal-title': 'Br. J. Clin. Pharmacol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib92', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fphar.2022.1078766', 'article-title': 'Targeting cancer-related inflammation with non-steroidal ' 'anti-inflammatory drugs: perspectives in pharmacogenomics', 'volume': '13', 'author': 'Lai', 'year': '2022', 'journal-title': 'Front. Pharmacol.'}, { 'issue': '12_Supplement', 'key': '10.1016/j.heliyon.2024.e25734_bib93', 'doi-asserted-by': 'crossref', 'DOI': '10.1158/1538-7445.AM2022-2166', 'article-title': 'Ibuprofen induces ferroptosis to potentiate antitumor immunity', 'volume': '82', 'author': 'Talty', 'year': '2022', 'journal-title': 'Cancer Res.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib94', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12950-020-00266-0', 'article-title': 'The NLRP3 inflammasome: an emerging therapeutic target for chronic pain', 'volume': '18', 'author': 'Chen', 'year': '2021', 'journal-title': 'J. Neuroinflammation'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib95', 'series-title': 'Scientific Brief: the Use of Non-steroidal Anti-inflammatory Drugs ' '(NSAIDs) in Patients with COVID-19', 'author': 'Organization', 'year': '2020'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib96', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2020.594963', 'article-title': 'Virus infections and host metabolism—can we manage the interactions?', 'volume': '11', 'author': 'Sumbria', 'year': '2021', 'journal-title': 'Front. Immunol.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib97', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2020.572677', 'article-title': 'HIV-1 infection and glucose metabolism reprogramming of T cells: ' 'another approach toward functional cure and reservoir eradication', 'volume': '11', 'author': 'Kang', 'year': '2020', 'journal-title': 'Front. Immunol.'}, { 'issue': '4', 'key': '10.1016/j.heliyon.2024.e25734_bib98', 'doi-asserted-by': 'crossref', 'first-page': '2358', 'DOI': '10.1128/JVI.02309-14', 'article-title': 'Dengue virus induces and requires glycolysis for optimal replication', 'volume': '89', 'author': 'Fontaine', 'year': '2015', 'journal-title': 'J. Virol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib99', 'doi-asserted-by': 'crossref', 'first-page': '64', 'DOI': '10.1016/j.immuni.2018.11.017', 'article-title': 'The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to ' 'promote an antiviral metabolic state in neurons', 'volume': '50', 'author': 'Daniels', 'year': '2019', 'journal-title': 'Immunity'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib100', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fimmu.2019.01533', 'article-title': 'Hijacking the supplies: metabolism as a novel facet of virus-host ' 'interaction', 'volume': '10', 'author': 'Mayer', 'year': '2019', 'journal-title': 'Front. Immunol.'}, { 'issue': '7', 'key': '10.1016/j.heliyon.2024.e25734_bib101', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.ppat.1002124', 'article-title': 'Divergent effects of human cytomegalovirus and herpes simplex virus-1 ' 'on cellular metabolism', 'volume': '7', 'author': 'Vastag', 'year': '2011', 'journal-title': 'PLoS Pathog.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib102', 'doi-asserted-by': 'crossref', 'first-page': '36', 'DOI': '10.1038/nri3581', 'article-title': 'Regulation of type I interferon responses', 'volume': '14', 'author': 'Ivashkiv', 'year': '2014', 'journal-title': 'Nat. Rev. Immunol.'}, { 'issue': '1', 'key': '10.1016/j.heliyon.2024.e25734_bib103', 'doi-asserted-by': 'crossref', 'first-page': '5126', 'DOI': '10.1038/s41598-018-22913-6', 'article-title': 'Association of NF-E2 related factor 2 (Nrf2) and inflammatory cytokines ' 'in recent onset type 2 diabetes mellitus', 'volume': '8', 'author': 'Sireesh', 'year': '2018', 'journal-title': 'Sci. Rep.'}, { 'issue': '13', 'key': '10.1016/j.heliyon.2024.e25734_bib104', 'doi-asserted-by': 'crossref', 'first-page': '2262', 'DOI': '10.1080/10408398.2020.1775546', 'article-title': 'Obesity as a risk factor for COVID-19: an overview', 'volume': '61', 'author': 'Alberca', 'year': '2021', 'journal-title': 'Crit. Rev. Food Sci. Nutr.'}, { 'issue': '8', 'key': '10.1016/j.heliyon.2024.e25734_bib105', 'doi-asserted-by': 'crossref', 'first-page': '1072', 'DOI': '10.1038/ijo.2011.208', 'article-title': 'Obesity is associated with impaired immune response to influenza ' 'vaccination in humans', 'volume': '36', 'author': 'Sheridan', 'year': '2012', 'journal-title': 'Int. J. Obes.'}, { 'issue': '10', 'key': '10.1016/j.heliyon.2024.e25734_bib106', 'doi-asserted-by': 'crossref', 'first-page': '3544', 'DOI': '10.3390/ijms21103544', 'article-title': 'The role of lipid metabolism in COVID-19 virus infection and as a drug ' 'target', 'volume': '21', 'author': 'Abu-Farha', 'year': '2020', 'journal-title': 'Int. J. Mol. Sci.'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2024.e25734_bib107', 'doi-asserted-by': 'crossref', 'first-page': '1004', 'DOI': '10.3390/nu13031004', 'article-title': 'Ketogenic diet as a preventive and supportive care for COVID-19 ' 'patients', 'volume': '13', 'author': 'Gangitano', 'year': '2021', 'journal-title': 'Nutrients'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib108', 'doi-asserted-by': 'crossref', 'first-page': '210', 'DOI': '10.1016/j.immuni.2022.01.004', 'article-title': 'Control of immunity via nutritional interventions', 'volume': '55', 'author': 'Collins', 'year': '2022', 'journal-title': 'Immunity'}, { 'issue': '6', 'key': '10.1016/j.heliyon.2024.e25734_bib109', 'doi-asserted-by': 'crossref', 'first-page': '2091', 'DOI': '10.1007/s10753-022-01680-7', 'article-title': 'The lactate and the lactate dehydrogenase in inflammatory diseases and ' 'major risk factors in COVID-19 patients', 'volume': '45', 'author': 'Gupta', 'year': '2022', 'journal-title': 'Inflammation'}, { 'issue': '3', 'key': '10.1016/j.heliyon.2024.e25734_bib110', 'doi-asserted-by': 'crossref', 'first-page': '602', 'DOI': '10.3390/v14030602', 'article-title': 'Hallmarks of metabolic reprogramming and their role in viral ' 'pathogenesis', 'volume': '14', 'author': 'Allen', 'year': '2022', 'journal-title': 'Viruses'}, { 'issue': '11', 'key': '10.1016/j.heliyon.2024.e25734_bib111', 'doi-asserted-by': 'crossref', 'first-page': '1250', 'DOI': '10.1177/10600280221075362', 'article-title': 'Ibuprofen-associated hypokalemia and metabolic acidosis: systematic ' 'literature review', 'volume': '56', 'author': 'Man', 'year': '2022', 'journal-title': 'Ann. Pharmacother.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib112', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.2147/OAEM.S22795', 'article-title': 'The patterns of toxicity and management of acute nonsteroidal ' 'anti-inflammatory drug (NSAID) overdose. Open access emergency medicine', 'volume': '3', 'author': 'Hunter', 'year': '2011', 'journal-title': 'OAEM'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib113', 'doi-asserted-by': 'crossref', 'first-page': '273', 'DOI': '10.2147/IJNRD.S121698', 'article-title': 'Selective cyclooxygenase-2 inhibitor use and progression of renal ' 'function in patients with chronic kidney disease: a single-center ' 'retrospective cohort study', 'volume': '9', 'author': 'Kaewput', 'year': '2016', 'journal-title': 'Int. J. Nephrol. Renovascular Dis.'}, { 'key': '10.1016/j.heliyon.2024.e25734_bib114', 'doi-asserted-by': 'crossref', 'first-page': 'S37', 'DOI': '10.1097/00005344-200605001-00007', 'article-title': 'COX-2 and the kidney', 'volume': '47', 'author': 'Harris', 'year': '2006', 'journal-title': 'J. Cardiovasc. Pharmacol.'}, { 'issue': '2', 'key': '10.1016/j.heliyon.2024.e25734_bib115', 'doi-asserted-by': 'crossref', 'first-page': '297', 'DOI': '10.1161/HYPERTENSIONAHA.117.09906', 'article-title': 'Cyclooxygenase-2 selectively controls renal blood flow through a novel ' 'PPARβ/δ-dependent vasodilator pathway', 'volume': '71', 'author': 'Kirkby', 'year': '2018', 'journal-title': 'Hypertension'}], 'container-title': 'Heliyon', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2405844024017651?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2405844024017651?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 2, 16]], 'date-time': '2024-02-16T23:29:43Z', 'timestamp': 1708126183000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2405844024017651'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 2]]}, 'references-count': 115, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2024, 2]]}}, 'alternative-id': ['S2405844024017651'], 'URL': 'http://dx.doi.org/10.1016/j.heliyon.2024.e25734', 'relation': {}, 'ISSN': ['2405-8440'], 'subject': ['Multidisciplinary'], 'container-title-short': 'Heliyon', 'published': {'date-parts': [[2024, 2]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Evaluating NSAIDs in SARS-CoV-2: Immunomodulatory mechanisms and future ' 'therapeutic strategies', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Heliyon', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.heliyon.2024.e25734', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2024 The Authors. 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