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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk Hospitalization time 28% c19early.org/d Mosadegh et al. IRCT20200426047206N1 Vitamin D RCT LATE Is late treatment with vitamin D+combined treatments beneficial for COVID-19? RCT 70 patients in Iran Lower mortality (p=0.0016) and shorter hospitalization (p=0.001) Mosadegh et al., Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105792 Favors vitamin D Favors control
The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trial
Mosadegh et al., Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105792, IRCT20200426047206N1
Mosadegh et al., The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients.., Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105792, IRCT20200426047206N1
Sep 2022   Source   PDF  
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RCT 70 hospitalized severe COVID-19 patients in Iran, showing lower mortality and improved clinical markers with treatment combining vitamins A, B1–B3, B5, B6, B9, C, D, K, and magnesium, potassium, phosphorus, sulfur, manganese, calcium, iron, boron, copper, zinc, omega-3, omega-6, and omega-9. The median age was lower in the treatment group 49 (29–77) vs. 55 (29–81). This study is excluded in meta analysis: combination of several treatments showing efficacy in other trials.
risk of death, 60.9% lower, RR 0.39, p = 0.002, treatment 9 of 35 (25.7%), control 23 of 35 (65.7%), NNT 2.5.
hospitalization time, 28.2% lower, relative time 0.72, p = 0.001, treatment 35, control 35.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mosadegh et al., 19 Sep 2022, Single Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, median age 48.7, 4 authors, this trial uses multiple treatments in the treatment arm (combined with vitamins A, B1–B3, B5, B6, B9, C, D, K, and magnesium, potassium, phosphorus, sulfur, manganese, calcium, iron, boron, copper, zinc, omega-3, omega-6, omega-9) - results of individual treatments may vary, trial IRCT20200426047206N1.
Contact: m-mosadegh@razi.tums.ac.ir.
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Abstract: Microbial Pathogenesis 172 (2022) 105792 Contents lists available at ScienceDirect Microbial Pathogenesis journal homepage: www.elsevier.com/locate/micpath The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trial Mehrdad Mosadegh a, *, Aref Khalkhali b, Yousef Erfani c, Manije Nezamdoost d a Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Science, Faculty of Biology, Islamic Azad University, Mashhad, Iran Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran d Department of Internal Medicine, Division of Infectious Disease, Farabi Hospital, Social Security Organization, Mashhad, Iran b c A R T I C L E I N F O A B S T R A C T Keywords: COVID-19 Nutrition bio-shield superfood Laboratory biomarkers Clinical trial study Iran Background: Nutrition Bio-shield Superfood (NBS) is an organic and viable herbal supplement that could improve the function of the immune system. The present study aims to determine the effect of NBS on disease severity and laboratory biomarkers in patients with COVID-19. Methods: This current study was a randomized, comparative, parallel two-arm and single-blind clinical trial study performed in Tehran, Iran. In total, 70 patients with COVID-19 were included in the present study and assigned to two groups including 1) intervention group (n = 35) and 2) control group (n = 35). All patients included in the intervention group received 4.5 gr daily rate of NBS superfood, three times the daily rate of 1.5 gr for 14 days. In contrast, patients included in the control group received a placebo three times a day for 14 days. The mea­ surement of laboratory parameters including CRP, ESR, D-Dimer, LDH, CPK, SGOT, SGPT, ALP, FBG, WBC count, PLT, and lymphocyte count was performed using standard kits and methods. Moreover, all serum samples were tested to determine the levels of IL-6 and TNF-ɑ using specific commercially available ELISA kits according to the instructions of the manufacturer. Results: A significant decrease in the mean serum level of several variables including CRP (p < 0.001), ESR (p < 0.001), D- Dimer (p = 0.001), LDH (p < 0.001), SGOT (p = 0.002), SGPT (p = 0.019), ALP (p < 0.001), WBC count (p < 0.001), body temperature (p = 0.013), IL-6 (p < 0.001), and TNF-α (p < 0.001) was seen 14 days after intervention from baseline in the intervention group than control group. In contrast, in the intervention group, the significant increase from baseline of lymphocyte percentage (p < 0.001) and oxygen saturation (p < 0.001) was seen 14 days after receiving NBS superfood than the control group. Conclusion: Results showed that the use of NBS superfood had various beneficial effects on COVID-19 disease severity. These results suggest that NBS superfood can be used as an effective natural supplement in the treat­ ment process of COVID-19 disease.
Late treatment
is less effective
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