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0 0.5 1 1.5 2+ Progression, dyspnea 25% Improvement Relative Risk Progression, fever 51% Progression, taste/smell 70% Progression, fatigue -10% Progression, cough 53% Progression, diarrhea 26% Diet for COVID-19  Mohajeri et al.  Prophylaxis Is a healthy diet beneficial for COVID-19? Retrospective 600 patients in Iran Lower progression with healthier diets (p=0.00003) c19early.org Mohajeri et al., Medicina, January 2023 Favors healthy diet Favors control

Adherence to the Mediterranean Diet Association with Serum Inflammatory Factors Stress Oxidative and Appetite in COVID-19 Patients

Mohajeri et al., Medicina, doi:10.3390/medicina59020227
Jan 2023  
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Diet for COVID-19
22nd treatment shown to reduce risk in June 2021
 
*, now known with p < 0.00000000001 from 28 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Retrospective 600 COVID-19 patients in Iran with moderate/severe CT scans, showing lower prevalence of dyspnea, fever, taste/smell abnormalities, and cough with high adherence to the Mediterranean diet in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of progression, 25.4% lower, RR 0.75, p < 0.001, higher quality diet 62 of 105 (59.0%), lower quality diet 392 of 495 (79.2%), NNT 5.0, dyspnea.
risk of progression, 51.1% lower, RR 0.49, p < 0.001, higher quality diet 50 of 105 (47.6%), lower quality diet 482 of 495 (97.4%), NNT 2.0, fever.
risk of progression, 70.3% lower, RR 0.30, p < 0.001, higher quality diet 23 of 105 (21.9%), lower quality diet 365 of 495 (73.7%), NNT 1.9, taste/smell.
risk of progression, 9.7% higher, RR 1.10, p = 0.03, higher quality diet 98 of 105 (93.3%), lower quality diet 421 of 495 (85.1%), fatigue.
risk of progression, 52.9% lower, RR 0.47, p < 0.001, higher quality diet 38 of 105 (36.2%), lower quality diet 380 of 495 (76.8%), NNT 2.5, cough.
risk of progression, 25.9% lower, RR 0.74, p = 0.007, higher quality diet 44 of 105 (41.9%), lower quality diet 280 of 495 (56.6%), NNT 6.8, diarrhea.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mohajeri et al., 26 Jan 2023, retrospective, Iran, peer-reviewed, survey, 3 authors. Contact: mahsa.mohajeri.93@gmail.com (corresponding author), arrigo.cicero@unibo.it.
This PaperDietAll
Adherence to the Mediterranean Diet Association with Serum Inflammatory Factors Stress Oxidative and Appetite in COVID-19 Patients
Mahsa Mohajeri, Reza Mohajery, Arrigo F G Cicero
Medicina, doi:10.3390/medicina59020227
Background and Objectives: The Mediterranean diet's bioactive components are suggested to strengthen the immune system and to exert anti-inflammatory actions. This study investigated the association between adherence to the Mediterranean diet with serum inflammatory factors, total antioxidant capacity, appetite, and symptoms of COVID-19 patients. Materials and Methods: This crosssectional study was conducted among 600 Iranian COVID-19 patients selected by a simple random method. The ten-item Mediterranean diet adherence questionnaire was used to assess diet adherence. At the beginning of the study, 5 cc of blood was taken from all patients for measurement of serum interleukin 1β) IL-1β), tumor necrosis factor (TNF-α), malondialdehyde (MDA), high sensitivity Creactive protein (hs-CRP) and total antioxidant capacity (TAC). A human ELISA kit with serial number 950.090.096 produced by the Diaclone Company was used to test this cytokine using the sandwich ELISA method. Results: One hundred and five patients presented a high adherence and 495 patients presented a low adherence to the Mediterranean diet. The incidence of fever, cough, diarrhea, taste changes, and pneumonia severity index were significantly lower in patients who adhered to the Mediterranean diet more than other patients. Serum levels of tumor necrosis factor (5.7 ± 2.1 vs. 6.9 ± 2.8 p = 0.02), interleukin 1 beta (3.2 ± 0.02 vs. 4.9 ± 0.01 p = 0.02), high-sensitivity C-reactive protein (17.08 ± 4.2 vs. 19.8 ± 2.5 p = 0.03), and malondialdehyde (5.7 ± 0.2 vs. 6.2 ± 0.3 p = 0.02) were significantly lower in patients who adhered more to the Mediterranean diet than other patients. Conclusion: The Mediterranean diet can improve the symptoms and elevated serum inflammatory factors in COVID-19 patients, so clinical trial studies are suggested to confirm this effect.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the patients to publish this paper. Data Availability Statement: Data is unavailable due to privacy or ethical restrictions. Conflicts of Interest: The authors declare no conflict of interest.
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