Does Losartan reduce the severity of COVID-19 in hypertensive patients?

DOI record: { "DOI": "10.1186/s12872-022-02548-2", "ISSN": [ "1471-2261" ], "URL": "http://dx.doi.org/10.1186/s12872-022-02548-2", "abstract": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>One of the global problems is to control the coronavirus epidemic, and the role of different medicines is still unknown to policymakers. This study was conducted to evaluate the effects of losartan on the mortality rate of COVID-19 in hypertensive patients.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>The research sample of analytical study included 1458 patients presenting to COVID-19 diagnostic centers in Yazd that were examined in the first six months of 2020. Data were analyzed using descriptive statistics as well as chi-square, Fisher’s exact test, <jats:italic>t</jats:italic> test, and logistic regression.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Of 1458 subjects that were studied, 280 were hypertensive of whom 179 tested positive for SARS-CoV-2 PCR. The results showed a lower chance of death by more than 5 times in hypertensive patients who used losartan (<jats:italic>P</jats:italic> = 0.003). Moreover, regarding the effect of losartan on the prevention of COVID-19 in hypertensive patients, it was found that this medicine played a protective role although this relationship was not statistically significant (<jats:italic>P</jats:italic> = 0.86).</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>The results showed that losartan reduced the chance of mortality in hypertensive patients. It is recommended that the effect of losartan and other blood pressure medicines on COVID-19 patients be investigated in larger studies as well as laboratory investigations.</jats:p>\n </jats:sec>", "alternative-id": [ "2548" ], "article-number": "116", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "22 August 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "8 March 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "19 March 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "<!--Emphasis Type='Bold' removed-->Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The article’s proposal was approved by the ethics committee of Shahid Sadoughi University of Medical Sciences with the ID of IR.SSU.REC.1399.101. Due to the retrospective nature of the study, no study specific consent form was used. However, patients admitted to our hospital are asked to sign a general consent upon admission, which covers the collection of patient data and publication of these results. Therefore, the individual’s informed consent was waived by the above ethics committee. We received administrative permission from (Secretary of University/Regional Research Ethics Committee Shahid Sadoughi University of Medical Sciences) to access and use the data. Data used in the study were anonymized. The ethics committee approved this procedure with the above ethical code. The present study was conducted in terms of the principles of the revised Declaration of Helsinki, which waived requirement for informed consent." }, { "group": { "label": "<!--Emphasis Type='Bold' removed-->Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "Not applicable." }, { "group": { "label": "<!--Emphasis Type='Bold' removed-->Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "All authors declare that they have no conflict of interest regarding this study." } ], "author": [ { "affiliation": [], "family": "Mirjalili", "given": "Mohammadreza", "sequence": "first" }, { "affiliation": [], "family": "Soodejani", "given": "Moslem Taheri", "sequence": "additional" }, { "affiliation": [], "family": "Raadabadi", "given": "Mehdi", "sequence": "additional" }, { "affiliation": [], "family": "Dehghani", "given": "Ali", "sequence": "additional" }, { "affiliation": [], "family": "Salemi", "given": "Fateme", "sequence": "additional" } ], "container-title": "BMC Cardiovascular Disorders", "container-title-short": "BMC Cardiovasc Disord", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 3, 19 ] ], "date-time": "2022-03-19T12:03:22Z", "timestamp": 1647691402000 }, "deposited": { "date-parts": [ [ 2022, 3, 19 ] ], "date-time": "2022-03-19T12:09:27Z", "timestamp": 1647691767000 }, "funder": [ { "award": [ "7867", "7867", "7867", "7867" ], "name": "Yazd University of Medical Sciences" } ], "indexed": { "date-parts": [ [ 2023, 9, 1 ] ], "date-time": "2023-09-01T10:24:29Z", "timestamp": 1693563869569 }, "is-referenced-by-count": 3, "issue": "1", "issued": { "date-parts": [ [ 2022, 3, 19 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2022, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 19 ] ], "date-time": "2022-03-19T00:00:00Z", "timestamp": 1647648000000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 19 ] ], "date-time": "2022-03-19T00:00:00Z", "timestamp": 1647648000000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s12872-022-02548-2.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s12872-022-02548-2/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s12872-022-02548-2.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2022, 3, 19 ] ] }, "published-online": { "date-parts": [ [ 2022, 3, 19 ] ] }, "published-print": { "date-parts": [ [ 2022, 12 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.3390/v12020135", "author": "LE Gralinski", "doi-asserted-by": "publisher", "first-page": "135", "issue": "2", "journal-title": "Viruses", "key": "2548_CR1", "unstructured": "Gralinski LE, Menachery VD. 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