All Studies Meta Analysis Recent:

Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2

Meskina et al., Therapeutic Archive, doi:10.26442/00403660.2021.04.200835

Jun 2021

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Probiotics for COVID-19

17th treatment shown to reduce risk in March 2021

^*, now known with p = 0.0000013 from 26 studies.

Lower risk for mortality, hospitalization, progression, recovery, and cases.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,000+ studies for 60+ treatments. c19early.org

RCT 100 pneumonia patients in Russia, showing faster symptom resolution with probiotic treatment (B. bifidum 1).

The immune effects of probiotics are strain-specific.

Important missing comments or errors? Let us know.

Meskina et al., 1 Jun 2021, Randomized Controlled Trial, Russia, peer-reviewed, 5 authors.

This Paper Probiotics All

Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period

Elena R Meskina, Elena E Tselipanova, Marima K Khadisova, Lidiya A Galkina, Tatyana V Stashko

Terapevticheskii arkhiv, doi:10.26442/00403660.2021.04.200835

Аннотация Цель. Определить клиническую эффективность и безопасность сорбированных пробиотиков Bifidobacterium bifidum 1 (5×10 8 КОЕ) и B. bifidum 1 (5×10 7 КОЕ) в сочетании с Lactobacillus plantarum 8P-А3 (5×10 7 КОЕ) для лечения пневмонии, вызванной SARS-CoV-2, увзрослыхпациентов,неимеющихтяжелыхфакторовриска. Материалы и методы.Воткрытоерандомизированноепроспективноеисследованиевключены100пациентовстарше18летсплощадью поражениялегкихнакомпьютернойтомограмменеболее75%.РНКSARS-CoV-2вмазкахизносаиротоглоткиобнаружена(методомполимеразнойцепнойреакцииобратнойтранскрипции)у72%участников.ДиагностикаCOVID-19,стандартноеобследованиеилечение проведенысогласноВременнымметодическимрекомендациямМинздраваРоссии,версия8от03.09.2020.Впубликациипредставлены результатыпримененияB. bifidum1по3капсулы2разавденьвтечение10дней.

References

Ahlawat, Sharma, Immunological co-ordination between gut and lungs in SARS-CoV-2 infection, Virus Res, doi:10.1016/j.virusres.2020.198103

Artese, Svicher, Costa, Current status of antivirals and druggable targets of SARSCoV-2 and other human pathogenic coronaviruses, Drug Resist Updat, doi:10.1016/j.drup.2020.100721

Gautret, Million, Jarrot, Natural history of COVID-19 and therapeutic options, Expert Rev Clin Immunol, doi:10.1080/1744666X.2021.1847640

Geva-Zatorsky, Sefik, Kua, Mining the Human Gut Microbiota for Immunomodulatory Organisms, Cell, doi:10.1016/j.cell.2017.01.022

Giacomelli, Pezzati, Conti, Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study, Clin Infect Dis, doi:10.1093/cid/ciaa330

Gohil, Samson, Dastager, Dharne, Probiotics in the prophylaxis of COVID-19: something is better than nothing, Biotech, doi:10.1007/s13205-020-02554-1

Gou, Fu, Yue, Gut microbiota may underlie the predisposition of healthy individuals to COVID-19, MedRix, doi:10.1101/2020.04.22.20076091

Hani, Trieu, Saab, COVID-19 pneumonia: A review of typical CT findings and differential diagnosis, Diagn Interv Imaging, doi:10.1016/j.diii.2020.03.014

Kavaz, Tahir, Bilek, Clinical significance of smell and taste dysfunction and other related factors in COVID-19, Eur Arch Otorhinolaryngol, doi:10.1007/s00405-020-06503-9

Larenas-Linnemann, Rodríguez-Pérez, Arias-Cruz, Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions, World Allergy Organ J, doi:10.1016/j.waojou.2020.100476

Mazidi, Rezaie, Ferns, Vatanparast, Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials, Nutrients, doi:10.3390/nu9010020

Mcilroy, Mullish, Goldenberg, Intestinal microbiome transfer, a novel therapeutic strategy for COVID-19 induced hyperinflammation?: In reply to, 'COVID-19: Immunology and treatment options, Clin Immunol, doi:10.1016/j.clim.2020.108542

Miller, Paradis, Houck, Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale, Psychiatry Res, doi:10.1016/0165-1781(92)90005-n

Nouri-Vaskeh, Sharifi, Khalili, Dyspneic and nondyspneic (silent) hypoxemia in COVID-19: Possible neurological m e c h a n i s m . C l i n N e u ro l N e u, ro s u rg, doi:10.1016/j.clineuro.2020.106217

Pan, Ye, Sun, Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19), Radiology, doi:10.1148/radiol.2020200370

Santos, Da Silva, Do, Silva, Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review, Am J Otolaryngol, doi:10.1016/j.amjoto.2020.102889

Segal, Mak, Mullish, The gut microbiome: an underrecognised contributor to the COVID-19 pandemic?, Therap Adv Gastroenterol, doi:10.1177/1756284820974914

Shahbazi, Yasavoli-Sharahi, Alsadi, Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders, Molecules, doi:10.3390/molecules25214891

Siemieniuk, Bartoszko, Ge, Drug treatments for Covid-19: living systematic review and network meta-analysis, BMJ, doi:10.1136/bmj.m2980

Stasi, Fallani, Voller, Silvestri, Treatment for COVID-19: An overview, Eur J Pharmacol, doi:10.1016/j.ejphar.2020.173644

Terapevticheskii Arkhiv, None, ТЕРАПЕВТИЧЕСКИЙ АРХИВ

Tobin, Laghi, Jubran, Why COVID-19 Silent Hypoxemia Is Baffling to Physicians, Am J Respir Crit Care Med, doi:10.1164/rccm.202006-2157CP

Vaira, Lechien, Khalife, Psychophysical Evaluation of the Olfactory Function: European Multicenter Study on 774 COVID-19

Ware, Snow, Kosinski, Gandek, Sf-36 Health Survey: Manual and Interpretation Guide

Yeoh, Zuo, Lui, Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19, Gut, doi:10.1136/gutjnl-2020-323020

Zuo, Liu, Zhang, Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19, Gut, doi:10.1136/gutjnl-2020-322294

Воз, Лекарственная терапия при COVID-19

Федерации, Временные методические рекомендации: профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0