Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period
Elena R Meskina, Elena E Tselipanova, Marima K Khadisova, Lidiya A Galkina, Tatyana V Stashko
Terapevticheskii arkhiv, doi:10.26442/00403660.2021.04.200835
Аннотация Цель. Определить клиническую эффективность и безопасность сорбированных пробиотиков Bifidobacterium bifidum 1 (5×10 8 КОЕ) и B. bifidum 1 (5×10 7 КОЕ) в сочетании с Lactobacillus plantarum 8P-А3 (5×10 7 КОЕ) для лечения пневмонии, вызванной SARS-CoV-2, увзрослыхпациентов,неимеющихтяжелыхфакторовриска. Материалы и методы.Воткрытоерандомизированноепроспективноеисследованиевключены100пациентовстарше18летсплощадью поражениялегкихнакомпьютернойтомограмменеболее75%.РНКSARS-CoV-2вмазкахизносаиротоглоткиобнаружена(методомполимеразнойцепнойреакцииобратнойтранскрипции)у72%участников.ДиагностикаCOVID-19,стандартноеобследованиеилечение проведенысогласноВременнымметодическимрекомендациямМинздраваРоссии,версия8от03.09.2020.Впубликациипредставлены результатыпримененияB. bifidum1по3капсулы2разавденьвтечение10дней.
References
Artese, Svicher, Costa, Current status of antivirals and druggable targets of SARSCoV-2 and other human pathogenic coronaviruses, Drug Resist Updat,
doi:10.1016/j.drup.2020.100721Giacomelli, Pezzati, Conti, Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study, Clin Infect Dis,
doi:10.1093/cid/ciaa330Hani, Trieu, Saab, COVID-19 pneumonia: A review of typical CT findings and differential diagnosis, Diagn Interv Imaging,
doi:10.1016/j.diii.2020.03.014Kavaz, Tahir, Bilek, Clinical significance of smell and taste dysfunction and other related factors in COVID-19, Eur Arch Otorhinolaryngol,
doi:10.1007/s00405-020-06503-9Larenas-Linnemann, Rodríguez-Pérez, Arias-Cruz, Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions, World Allergy Organ J,
doi:10.1016/j.waojou.2020.100476Mazidi, Rezaie, Ferns, Vatanparast, Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials, Nutrients,
doi:10.3390/nu9010020Mcilroy, Mullish, Goldenberg, Intestinal microbiome transfer, a novel therapeutic strategy for COVID-19 induced hyperinflammation?: In reply to, 'COVID-19: Immunology and treatment options, Clin Immunol,
doi:10.1016/j.clim.2020.108542Miller, Paradis, Houck, Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale, Psychiatry Res,
doi:10.1016/0165-1781(92)90005-nNouri-Vaskeh, Sharifi, Khalili, Dyspneic and nondyspneic (silent) hypoxemia in COVID-19: Possible neurological m e c h a n i s m . C l i n N e u ro l N e u, ro s u rg,
doi:10.1016/j.clineuro.2020.106217Pan, Ye, Sun, Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19), Radiology,
doi:10.1148/radiol.2020200370Santos, Da Silva, Do, Silva, Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review, Am J Otolaryngol,
doi:10.1016/j.amjoto.2020.102889Segal, Mak, Mullish, The gut microbiome: an underrecognised contributor to the COVID-19 pandemic?, Therap Adv Gastroenterol,
doi:10.1177/1756284820974914Shahbazi, Yasavoli-Sharahi, Alsadi, Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders, Molecules,
doi:10.3390/molecules25214891Siemieniuk, Bartoszko, Ge, Drug treatments for Covid-19: living systematic review and network meta-analysis, BMJ,
doi:10.1136/bmj.m2980Terapevticheskii Arkhiv, None, ТЕРАПЕВТИЧЕСКИЙ АРХИВ
Vaira, Lechien, Khalife, Psychophysical Evaluation of the Olfactory Function: European Multicenter Study on 774 COVID-19
Ware, Snow, Kosinski, Gandek, Sf-36 Health Survey: Manual and Interpretation Guide
Yeoh, Zuo, Lui, Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19, Gut,
doi:10.1136/gutjnl-2020-323020Zuo, Liu, Zhang, Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19, Gut,
doi:10.1136/gutjnl-2020-322294Воз, Лекарственная терапия при COVID-19
Федерации, Временные методические рекомендации: профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19
{ 'indexed': {'date-parts': [[2024, 4, 1]], 'date-time': '2024-04-01T15:10:58Z', 'timestamp': 1711984258648},
'reference-count': 27,
'publisher': 'Consilium Medicum',
'issue': '4',
'license': [ { 'start': { 'date-parts': [[2021, 4, 15]],
'date-time': '2021-04-15T00:00:00Z',
'timestamp': 1618444800000},
'content-version': 'unspecified',
'delay-in-days': 0,
'URL': 'https://creativecommons.org/licenses/by-nc-sa/4.0'}],
'content-domain': {'domain': [], 'crossmark-restriction': False},
'abstract': '<jats:p>Aim. To determine the clinical efficacy and safety of the sorbed probiotics '
'Bifidobacterium bifidum 1 (5108 KОЕ) and B. bifidum 1 (5107 KОЕ) in combination with '
'Lactobacillus plantarum 8P-А3 in the complex therapy of pneumonia caused by SARS-CoV-2 in '
'adult patients without severe risk factors.
\n'
'Materials and methods. An open, randomized prospective study included 100 patients (45 men, '
'55 women), aged 18 to 60 years without risk factors for severe COVID-19 with pneumonia '
'confirmed by computed tomography, and an area of lung lesion no more than 75% (moderate '
'forms). SARS-CoV-2 RNA in nasal and oropharyngeal swabs (RT-PCR) was detected in 72% of the '
'participants, in the rest it was highly probable in terms of the aggregate parameters. '
'Diagnostics of COVID-19 and its severity, the appointment of a standard examination and '
'treatment were carried out in accordance with the Temporary Methodological Recommendations of '
'the Ministry of Health of Russia, version 8 of 09.03.2020. This publication presents the '
'results of using B. bifidum 1 (3 capsules twice a day for 10 days) during the peak of '
'clinical manifestations (in a hospital).
\n'
'Results. In those who received sorbed B. bifidum 1, by the 10th day of treatment, the '
'frequency of weakness was 32% lower (RR 0.55 [95% CI 0.240.73], OR 0.25 [0.110.59]); '
'hypoosmia/dysgeusia by 22% (RR 0.42 [0.050.65], OR 0.40 [0.170.90]) and cough by 24% (RR '
'0.39 [0.070.60], OR 0.38 [0.170.84]). B. bifidum 1 reduced the average duration of weakness '
'by 3 days [1.14.9], hypoosmia/dysgeusia by 3.2 days [1.35.1], cough by 1.9 days [0.43,4], '
'dyspnea by 1.8 days [0.72.7], diarrhea by 1.7 days [0.13.5]; reduced the risk of '
'antibiotic-associated diarrhea by 20% (RR 0.77 [0.240.93], OR 0.18 [0.050.68]). Due to the '
'deterioration of the condition and the increase in the symptoms of respiratory failure, '
'additional treatment was required less often by 24% (p=0.005). After the end of the '
'intervention, the frequency of virologic debridement, levels of CRP, leukocytes, lymphocytes, '
'platelets and the degree of lung damage on computed tomography did not statistically differ '
'in the compared groups. No side effects of B. bifidum 1 (5108 KОЕ) have been '
'identified.
\n'
'Conclusion. The use of sorbed B. bifidum 1 (5108 KОЕ) improved the well-being of patients '
'without risk factors with moderate viral (SARS-CoV-2) pneumonia and reduced the duration of '
'diarrheal syndrome in a short time. The safety profile of their use was high. More research '
'is needed to clarify the anti-inflammatory effects of the sorbed probiotic.</jats:p>',
'DOI': '10.26442/00403660.2021.04.200835',
'type': 'journal-article',
'created': {'date-parts': [[2021, 6, 23]], 'date-time': '2021-06-23T14:24:03Z', 'timestamp': 1624458243000},
'page': '456-464',
'source': 'Crossref',
'is-referenced-by-count': 8,
'title': 'Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by '
'SARS-CoV-2. Part 1. Heating clinical displays period',
'prefix': '10.26442',
'volume': '93',
'author': [ { 'ORCID': 'http://orcid.org/0000-0002-1960-6868',
'authenticated-orcid': False,
'given': 'Elena R.',
'family': 'Meskina',
'sequence': 'first',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-0586-8402',
'authenticated-orcid': False,
'given': 'Elena E.',
'family': 'Tselipanova',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-8293-6643',
'authenticated-orcid': False,
'given': 'Marima K.',
'family': 'Khadisova',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-0052-2867',
'authenticated-orcid': False,
'given': 'Lidiya A.',
'family': 'Galkina',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-9654-9863',
'authenticated-orcid': False,
'given': 'Tatyana V.',
'family': 'Stashko',
'sequence': 'additional',
'affiliation': []}],
'member': '18344',
'published-online': {'date-parts': [[2021, 4, 15]]},
'reference': [ { 'key': 'ref1',
'unstructured': 'Министерство здравоохранения Российской Федерации. Временные '
'методические рекомендации: профилактика, диагностика и лечение новой '
'коронавирусной инфекции (COVID-19). Версия 10 (08.02.2021). Режим '
'доступа: '
'https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/054/588/original/%D0%92%D1%80%D0%B5%D0%BC%D0%B5%D0%BD%D0%BD%D1%8B%D0%B5_%D0%9C%D0%A0_COVID-19_%28v.10%29-08.02.2021_%281%29.pdf. '
'Ссылка активна на: 16.03.2021 [Ministry of Health of the Russian '
'Federation. Interim Guidelines: Prevention, Diagnosis and Treatment of '
'Novel Coronavirus Infection (COVID-19). Version 10 (02/08/2021). '
'Available at: '
'https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/054/588/original/%D0%92%D1%80%D0%B5%D0%BC%D0%B5%D0%BD%D0%BD%D1%8B%D0%B5_%D0%9C%D0%A0_COVID-19_%28v.10%29-08.02.2021_%281%29.pdf. '
'Accessed: 16.03.2021 (In Russ.)].'},
{'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejphar.2020.173644'},
{'key': 'ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.drup.2020.100721'},
{'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.m2980'},
{ 'key': 'ref5',
'unstructured': 'ВОЗ. Лекарственная терапия при COVID-19. Вариативные рекомендации 20 '
'ноября 2020 года. Режим доступа: '
'https://apps.who.int/iris/bitstream/handle/10665/336729/WHO-2019-nCov-remdesivir-2020.1-rus.pdf?sequence=7&isAllowed=y. '
'Ссылка активна на: 23.01.2020 [WHO. Drug therapy for COVID-19. Variable '
'Recommendations November 20, 2020. Available at: '
'https://apps.who.int/iris/bitstream/handle/10665/336729/WHO-2019-nCov-remdesivir-2020.1-rus.pdf?sequence=7&isAllowed=y. '
'Accessed: 23.01.2020 (In Russ.)].'},
{'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/1756284820974914'},
{'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.clim.2020.108542'},
{'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.virusres.2020.198103'},
{'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/gutjnl-2020-323020'},
{'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cell.2017.01.022'},
{'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/gutjnl-2020-322294'},
{'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s13205-020-02554-1'},
{'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.waojou.2020.100476'},
{'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/0165-1781(92)90005-n'},
{ 'key': 'ref15',
'unstructured': 'Ware JЕ, Snow KK, Kosinski М, Gandek В. Sf-36 Health Survey: Manual and '
'Interpretation Guide. Lincoln RI: Quality Metric Incorporated, 2000.'},
{'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/1744666X.2021.1847640'},
{'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.amjoto.2020.102889'},
{'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00405-020-06503-9'},
{'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/pathogens10010062'},
{'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/cid/ciaa330'},
{'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.202006-2157CP'},
{'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.clineuro.2020.106217'},
{'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.04.22.20076091'},
{'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/molecules25214891'},
{'key': 'ref25', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu9010020'},
{'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.1148/radiol.2020200370'},
{'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.diii.2020.03.014'}],
'container-title': 'Terapevticheskii arkhiv',
'original-title': [],
'link': [ { 'URL': 'https://ter-arkhiv.ru/0040-3660/article/viewFile/71232/52027',
'content-type': 'application/pdf',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://ter-arkhiv.ru/0040-3660/article/viewFile/71232/52027',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2021, 10, 13]],
'date-time': '2021-10-13T19:52:35Z',
'timestamp': 1634154755000},
'score': 1,
'resource': {'primary': {'URL': 'https://ter-arkhiv.ru/0040-3660/article/view/71232'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2021, 4, 15]]},
'references-count': 27,
'journal-issue': {'issue': '4', 'published-online': {'date-parts': [[2021, 4, 15]]}},
'URL': 'http://dx.doi.org/10.26442/00403660.2021.04.200835',
'relation': {},
'ISSN': ['2309-5342', '0040-3660'],
'subject': [],
'container-title-short': 'Terapevticheskii arkhiv',
'published': {'date-parts': [[2021, 4, 15]]}}
