COVID-19 Case Series at UnityPoint Health St. Luke’s Hospital in Cedar Rapids, IA

{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2023, 8, 28]], 'date-time': '2023-08-28T13:01:47Z', 'timestamp': 1693227707678}, 'posted': {'date-parts': [[2020, 7, 19]]}, 'group-title': 'Infectious Diseases (except HIV/AIDS)', 'reference-count': 16, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 7, 19]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>A retrospective, descriptive study of all patients ' 'tested for SARS-CoV2 on admission for illness to a community hospital in Iowa from 3/21/20 ' 'thru 6/14/20 consisted of evaluation as to demographics, presentation and hospital course. ' 'Ninety-one patients were SARS-CoV2 PCR+ with 63% being male and a median age of 60. ' 'Cardiovascular disease was a significant comorbidity in the PCR+ group. Fever, cough, ' 'dyspnea, nausea, emesis, diarrhea, headache and myalgias were significantly more common in ' 'that group, as was an elevated CRP, LDH, serum ferritin and transaminases. Overall survival ' 'of the COVID-19 patients was 88%, 77% in the critically ill, 59% of those mechanically ' 'ventilated and 33% of those requiring new dialysis. Survival was 93% in those not receiving ' 'any antivirals. Survival of those treated with hydroxychloroquine-azithromycin was 92%, ' 'compared to 86% of those treated with hydroxychloroquine alone. The latter two groups were ' 'significantly more ill than the untreated group. A transition from an early intubation ' 'strategy to aggressive utilization of high flow nasal cannula and noninvasive ventilation(i.e ' 'BiPAP) was successful in freeing up ICU resources.</jats:p>', 'DOI': '10.1101/2020.07.17.20156521', 'type': 'posted-content', 'created': {'date-parts': [[2020, 7, 19]], 'date-time': '2020-07-19T15:55:12Z', 'timestamp': 1595174112000}, 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': 'COVID-19 Case Series at UnityPoint Health St. Luke’s Hospital in Cedar Rapids, IA', 'prefix': '10.1101', 'author': [ {'given': 'Dianna', 'family': 'Edwards', 'sequence': 'first', 'affiliation': []}, {'given': 'Daniel', 'family': 'McGrail', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2021011423251240000_2020.07.17.20156521v1.1', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.4326'}, { 'key': '2021011423251240000_2020.07.17.20156521v1.2', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2004500'}, { 'key': '2021011423251240000_2020.07.17.20156521v1.3', 'doi-asserted-by': 'crossref', 'unstructured': 'Fantini J , et al. Synergistic antiviral effect of hydroxychloroquine ' 'and azithromycin in combination against SARS-CoV-2: what molecular ' 'dynamics studies of virus-host interactions reveal. International ' 'Journal of Antimicrobial Agents.2020; ' '(https://www.sciencedirect.com/science/article/pii/S0924857920301837?via=ihub)', 'DOI': '10.1016/j.ijantimicag.2020.106020'}, { 'key': '2021011423251240000_2020.07.17.20156521v1.4', 'unstructured': 'Gautreta P , et al. Hydroxychloroquine and azithromycin as a treatment ' 'of COVID-19 -results of an open label non-randomized clinical trial. 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Doi: 10.1002/emp2.12071', 'DOI': '10.1002/emp2.12071'}], 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://syndication.highwire.org/content/doi/10.1101/2020.07.17.20156521', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 1, 15]], 'date-time': '2021-01-15T07:25:38Z', 'timestamp': 1610695538000}, 'score': 1, 'resource': {'primary': {'URL': 'http://medrxiv.org/lookup/doi/10.1101/2020.07.17.20156521'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 7, 19]]}, 'references-count': 16, 'URL': 'http://dx.doi.org/10.1101/2020.07.17.20156521', 'relation': {}, 'published': {'date-parts': [[2020, 7, 19]]}, 'subtype': 'preprint'}