5-alpha-reductase inhibitors are associated with reduced frequency of COVID-19 symptoms in males with androgenetic alopecia
J Mccoy
We have previously reported that men with androgenetic alopecia (AGA) are more likely to present with severe COVID-19 symptoms, potentially implicating androgen sensitivity as a risk factor for COVID-19. [1] [2] [3] As such, we hypothesized that 5-alphareductase inhibitors (5ARi) may reduce the severity of COVID-19 disease. To test this hypothesis, we conducted a retrospective cohort analysis on male subjects with laboratory confirmed SARS-CoV-2 infection. The subjects presented at one of five outpatient clinics (Corpometria Institute Brasilia, Brazil) from 15 June to 28 July 2020. At the time of visit, 29 clinical symptoms associated with SARS-CoV-2 infection were documented. For analysis, male subjects with AGA were selected. The frequency of clinical symptoms in males with AGA using 5ARis was compared to those not using 5ARis. Among the men presenting at the clinic, 300 were positive for SARS-CoV-2. Of these, 65 had AGA but were not using 5ARis, and 48 had AGA and were taking a 5ARi for at least six months prior to the study. The only 5ARi used in this cohort was dutasteride (0.5 mg) for the treatment of AGA. Propensity score
Conflicts of interest
References
Clark, Hermann, Cunningham, Wilson, Morrill et al., Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5a-reductase inhibitor, J Clin Endocrinol Metab,
doi:10.1111/jdv.17021Gebhard, Regitz-Zagrosek, Neuhauser, Morgan, Klein, Impact of sex and gender on COVID-19 outcomes in Europe, Biol Sex Differ
Goren, Vaño-Galv An, Wambier, A preliminary observation: male pattern hair loss among hospitalized COVID-19 patients in Spain -a potential clue to the role of androgens in COVID-19 severity, J Cosmet Dermatol
Montopoli, Zumerle, Vettor, Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a populationbased study (n=4532), Ann Oncol,
doi:10.1016/j.annonc.2020.04.479Wambier, Vaño-Galv An, Mccoy, Androgenetic alopecia present in the majority of hospitalized COVID-19 patients -the "Gabrin sign, J Am Acad Dermatol,
doi:10.1016/j.jaad.2020.05.079Wambier, Vaño-Galv An, Mccoy, Pai, Dhurat et al., Androgenetic alopecia in COVID-19: compared to age-matched epidemiologic studies and hospital outcomes with or without the Gabrin sign, J Am Acad Dermatol,
doi:10.1016/j.jaad.2020.07.099{ 'indexed': {'date-parts': [[2024, 4, 5]], 'date-time': '2024-04-05T00:55:27Z', 'timestamp': 1712278527749},
'reference-count': 6,
'publisher': 'Wiley',
'issue': '4',
'license': [ { 'start': { 'date-parts': [[2020, 11, 22]],
'date-time': '2020-11-22T00:00:00Z',
'timestamp': 1606003200000},
'content-version': 'vor',
'delay-in-days': 0,
'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}],
'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True},
'published-print': {'date-parts': [[2021, 4]]},
'DOI': '10.1111/jdv.17021',
'type': 'journal-article',
'created': {'date-parts': [[2020, 11, 2]], 'date-time': '2020-11-02T08:35:05Z', 'timestamp': 1604306105000},
'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy',
'source': 'Crossref',
'is-referenced-by-count': 33,
'title': '5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males '
'with androgenetic alopecia',
'prefix': '10.1111',
'volume': '35',
'author': [ { 'ORCID': 'http://orcid.org/0000-0003-1577-9910',
'authenticated-orcid': False,
'given': 'J.',
'family': 'McCoy',
'sequence': 'first',
'affiliation': [{'name': 'Applied Biology, Inc. Irvine CA USA'}]},
{ 'given': 'F.A.',
'family': 'Cadegiani',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Clinical Endocrinology Federal University of São '
'Paulo Medical School Sao Paulo Brazil'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-4636-4489',
'authenticated-orcid': False,
'given': 'C.G.',
'family': 'Wambier',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Dermatology Alpert Medical School of Brown '
'University Providence RI USA'}]},
{ 'given': 'S.',
'family': 'Herrera',
'sequence': 'additional',
'affiliation': [{'name': 'Infectious Diseases Unit Ramón y Cajal Hospital Madrid Spain'}]},
{ 'ORCID': 'http://orcid.org/0000-0003-2773-7494',
'authenticated-orcid': False,
'given': 'S.',
'family': 'Vaño‐Galván',
'sequence': 'additional',
'affiliation': [{'name': 'Dermatology Department Ramón y Cajal Hospital Madrid Spain'}]},
{ 'given': 'N.A.',
'family': 'Mesinkovska',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Dermatology University of Claifornia Irvine CA '
'USA'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-1561-414X',
'authenticated-orcid': False,
'given': 'P.M.',
'family': 'Ramos',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Dermatology São Paulo State University – UNESP São '
'Paulo Brazil'}]},
{ 'given': 'J.',
'family': 'Shapiro',
'sequence': 'additional',
'affiliation': [ { 'name': 'Ronald O. Perelman Department of Dermatology New York University '
'School of Medicine New York NY USA'}]},
{ 'given': 'R.',
'family': 'Sinclair',
'sequence': 'additional',
'affiliation': [{'name': 'Sinclair Dermatology Melbourne Vic. Australia'}]},
{ 'given': 'A.',
'family': 'Tosti',
'sequence': 'additional',
'affiliation': [ { 'name': 'Department of Dermatology and Cutaneous Surgery Miller School of '
'Medicine University of Miami Miami FL USA'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-8190-2289',
'authenticated-orcid': False,
'given': 'A.',
'family': 'Goren',
'sequence': 'additional',
'affiliation': [{'name': 'Applied Biology, Inc. Irvine CA USA'}]}],
'member': '311',
'published-online': {'date-parts': [[2020, 11, 22]]},
'reference': [ { 'key': 'e_1_2_1_5_2_1',
'doi-asserted-by': 'publisher',
'DOI': '10.1016/j.jaad.2020.05.079'},
{'key': 'e_1_2_1_5_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/jocd.13443'},
{ 'key': 'e_1_2_1_5_4_1',
'doi-asserted-by': 'publisher',
'DOI': '10.1016/j.jaad.2020.07.099'},
{ 'key': 'e_1_2_1_5_5_1',
'doi-asserted-by': 'publisher',
'DOI': '10.1186/s13293-020-00304-9'},
{ 'key': 'e_1_2_1_5_6_1',
'doi-asserted-by': 'publisher',
'DOI': '10.1016/j.annonc.2020.04.479'},
{'key': 'e_1_2_1_5_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1210/jc.2003-030330'}],
'container-title': 'Journal of the European Academy of Dermatology and Venereology',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdv.17021',
'content-type': 'application/pdf',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jdv.17021',
'content-type': 'application/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdv.17021',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2023, 9, 1]],
'date-time': '2023-09-01T17:13:39Z',
'timestamp': 1693588419000},
'score': 1,
'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/jdv.17021'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2020, 11, 22]]},
'references-count': 6,
'journal-issue': {'issue': '4', 'published-print': {'date-parts': [[2021, 4]]}},
'alternative-id': ['10.1111/jdv.17021'],
'URL': 'http://dx.doi.org/10.1111/jdv.17021',
'relation': {},
'ISSN': ['0926-9959', '1468-3083'],
'subject': [],
'container-title-short': 'Acad Dermatol Venereol',
'published': {'date-parts': [[2020, 11, 22]]},
'assertion': [ { 'value': '2020-11-22',
'order': 2,
'name': 'published',
'label': 'Published',
'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
